Phase I safety and immunogenicity trial of Plasmodium vivax CS derived long synthetic peptides adjuvanted with montanide ISA 720 or montanide ISA 51.

We assessed the safety, tolerability, and immunogenicity of a mixture of three synthetic peptides derived from the Plasmodium vivax circumsporozoite protein formulated in Montanide ISA 720 or Montanide ISA 51. Forty healthy malaria-naive volunteers were allocated to five experimental groups (A-E): four groups (A-D) were immunized intramuscularly with 50 and 100 μg/dose injections of a mixture of N, R, and C peptides formulated in the two different adjuvants at 0, 2, and 4 months and one group was administered placebo. Vaccines were immunogenic, safe, well tolerated, and no serious adverse events related to the vaccine occurred. Seroconversion occurred in > 90% of the vaccines and antibodies recognized the sporozoite protein on immunofluorescent antibody test. Vaccines in Montanide ISA 51 showed a higher sporozoite protein recognition and interferon production. Results encourage further testing of the vaccine protective efficacy.

[Album français. Souvenir de l'Exposition 1900, 51 vues phot. en dépliant, des collections du prince R. Bonaparte]

Donateur : Bonaparte, Roland (1858-1924)

[Collection de cartes postales classées méthodiquement pour l'enseignement de la géographie, Paris, F. Nathan, s.d. (1928), offert par l'éditeur. 353 cartes postales en 15 paquets. 1. Généralités, définitions principales (1-25) 2. Ports de commerce, de pêche, militaires, fluviaux (26-50) 3. Pêches et industries diverses (51-75) 4. Relief du sol (76-95) 5. Communications en montagne (96-119) 6. Histoire d'un fleuve (120-139) 7. Phénomènes dus à l'érosion (140-159) 8. Voies de communication (160-179) 9. Paris (180-204) 10. Algérie (205-228) 11. Tunisie (229-253) 12. Maroc (254-278) 13. A.O.F. et A.E.F. (279-303) 14. Madagascar (304-328) 15. Indochine (329-353)]

Donateur : Nathan, Fernand (1858-1947)

Hämäläinen Talvi voatteissaan : R. W. Ekman Kuv. ja piirittännytt

Tukhulmissa : Painettu M. G. Lundbergin Kirja-pajassa 1831

Someron pitäjässä talvi-ilta : pinx. R. W. Ekman

Helsingfors : K.E. Holm 1885, A. Weger

Kehitysmaat ja ravinto : N. W. Pirien haastattelu

Nimekkeen selitys: Englantilaisen biologin ja kasvitieteilijän N. W. Pirien haastattelu mm. hänen tutkimuksistaan käyttää kasvien lehtien valkuaista ravintona kehitysmaissa.

Plan af Kuopio stad utgifven 1838 af C. W. Gyldén

Kuopion kartta. 1 kartta : vär. ; 41,2 x 55,6 cm, lehti 45 x 60 cm. - Mittakaava: [1:8000]. - Sisältää luettelon julkisista rakennuksista.

Plan af Nystad utgifven år 1843 af C. W. Gyldén

Uudenkaupungin kartta. - 1 kartta : vär. ; 39,5 x 55,4 cm, lehti 45 x 60 cm. - Mittakaava [1:8000]. - Sisältää luettelot kortteleista ja julkisista rakennuksista.

W kraju tysiaca jezior: (z podró·zy i przechadzek po Finlandyi)

Lisäpainokset: 2. p. 1897.

W kraju tysiaca jezior: (z podró·zy i przechadzek po Finlandyi)

Lisäpainokset: 2. p. 1897.

Voucher #7 from the Engineer Department of Port Dalhousie and Thorold Railway Extension to W.G. Thompson accompanied by an abstract of vouchers and summaries of account paid by W.G. Thompson for surveys, Jan. 31, 1857

Voucher #7 from the Engineer Department of Port Dalhousie and Thorold Railway Extension to W.G. Thompson accompanied by an abstract of vouchers and summaries of account paid by W.G. Thompson for surveys, Jan. 31, 1857.

Examination of W. George Richardson, clerk to William Richardson, Brantford, Post Master

Examination of W. George Richardson, clerk to William Richardson, Brantford, Post Master (2 pages, handwritten). This is stained and contains small holes. The text is not affected, 1830.