SYNTHESIS AND BIOLOGICAL EVALUATION OF SPIRO[INDOLINE-3,4’-PYRANO[2,3-C:6,5-C’]DIPYRAZOL]- 2-ONES IN THE PRESENCE OF SBA-Pr-SO3H AS A NANOCATALYST

Sulfonic acid functionalized SBA-15 nanoporous material (SBA-Pr-SO3H) with a large pore size of 6 nm, a high surface area, high selectivity, and excellent chemical and thermal stability was applied as an efficient heterogeneous nanoporous acid catalyst in the reaction of isatin with pyrazolones under mild reaction conditions. A novel class of symmetrical spiro[indoline-3,4'-pyrano[2,3-c:6,5-c']dipyrazol]-2-one derivatives was successfully obtained in high yields. Comparison of these results with those reported in the literature shows that the current method is efficient, and results in better reaction times and yields of the desired products. Other advantages of this new method are its operational simplicity, easy work-up procedure, and the use of SBA-Pr-SO3H as a reusable and environmentally benign nanoreactor, such that the reaction proceeds easily in its nanopores. We also tested the antimicrobial activity of the prepared compounds using the disc diffusion method, and some of the synthesized compounds exhibited the best results against B. subtilis and S. aureus.

Testiohjelmiston kehittäminen väsytyskokeiden suorittamiseksi mielivaltaisilla kuormituksilla

Väsytyskokeita on väsymisilmiön keksimisestä lähtien tehty pääasiallisesti vakioamplitudisella kuormituksella. Paremmin todellisuutta kuvaavaan testitilanteeseen päästään kuitenkin vain käyttämällä testattavan rakenteen reaalikuormitusta simuloivaa muuttuva-amplitudista kuormitusta. Tällaisen kuormituksen testaaminen käytännössä on kuitenkin huomattavasti vaikeampaa kuin perinteisen vakioamplitudisen kuormituksen, koska muuttuva-amplitudisen kuormituksen spektri on ensin kehitettävä jostain – joko käytännön mittausten kautta tai rakenteen käyttötilaa analysoimalla. Myöskään tiedossa olevan spektrin tuottaminen käytännön kokeissa ei ole aivan yksinkertaista. Tässä kandidaatintyössä pyrittiin ratkaisemaan näitä ongelmia suunnittelemalla ja toteuttamalla testiohjelmisto, joka pystyy sekä generoimaan että käytännössä toistamaan käyttäjän haluaman kuormitusspektrin laboratoriokokeissa. Jälkimmäistä varten oli olemassa ohjelma, jota haluttiin hyödyntää tässä työssä. Tehtävä jaettiin kolmeen osioon: kuormitusspektrien generoiminen, kuormitusspektrien yhdistäminen ja lopuksi spektrien toistaminen itse väsytyskokeessa. Kahdessa ensimmäisessä osiossa käytettiin ohjelmointiympäristönä Matlab-ohjelmaa; kolmannessa käytettiin pohjana olemassa olevaa väsytyskoeohjelmaa ja käytännön ohjelmointi suoritettiin näin ollen ANSI C –kielellä käyttäen kääntäjänä Microsoft Visual Studio 6.0:aa. Alkuperäinen väsytyskoeohjelma vaati useita merkittäviä muutoksia, ennen kuin se soveltui käytettäväksi tässä yhteydessä. Työssä on kuvattu periaatetasolla ohjelmien suunnittelu- ja toteuttamisvaiheet. Lisäksi työn on tarkoitus toimia yksinkertaisena käyttöohjeena ja opastuksena koko ohjelmiston käyttöön.

Seiberling hinnasto N:o 15 6.0.1933

kuv., 11 x 14 cm

Estudo de reatividade e resolução enantiomérica do (+-)-10-exo-hidróxipentaciclo[6.2.1.1 3,6.0 2,7. 0 5.9] dodecan-4-ona

Neste trabalho, realizou-se a síntese do ceto-álcool pentaciclíco (±)-5, assim como o estudo de reatividade do grupo carbonila do mesmo frente a reações de oximação e redução. Realizou-se também a resolução enantiomérica do composto (±)-5 através de reação de transesterificação com acetato de vinila catalisada pela lipase da Candida rugosa. Altos excessos enantioméricos foram obtidos (>95%, RMN) tanto para o álcool (+)-5 quanto para o éster formado (-)-8. Sugere-se a existência de uma interconversão enantiomérica no composto (+)-5, devido a observação de mistura racêmica, quando o mesmo foi analisado por cromatografia gasosa em coluna quiral. Um mecanismo para tal interconversão, o qual envolve um rearranjo intramolecular, é proposto.

An unusual C-6-C-6 '' linked flavonoid from Miconia cabucu (Melastomataceae)

Chromatographic fractionation of the methanolic extract from the leaves of Miconia cabucu Hoehne (Melastomataceae) afforded the first example of a C-6-C-6 linked flavone dimer, 5-hydroxy-4',7-dimethoxyflavone-(6-C-6)-5-hydroxy-3 4',7-trimethoxyflavone as well as the known compounds, quercetin- 3-O-alpha-L- rhamnopyranosyl-(2 -> 1)-O-beta-D-xylopyranoside, quercetin-3-O-alpha-L-rhamnopyranoside, myricetin-3-O-alpha-L-rhamnopyranoside, quercetin-3-O-beta-D-glucopyranoside, kaempferol -3-O-beta-D-(6-coumaroyl) -glucopyranoside and gallic acid. Their chemical identities were established by application of NMR spectroscopic methods including 2D-NMR, as well as UV and ESI-MS analyses. (c) 2007 Elsevier Ltd. All rights reserved.

Parallel synthesis and nucleic acid binding properties of C(6')-[alpha]-functionalized bicyclo-DNA

Two novel bicyclo-T nucleosides carrying a hydroxyl or a carboxymethyl substituent in C(6')-[alpha]-position were prepared and incorporated into oligodeoxynucleotides. During oligonucleotide deprotection the carboxymethyl substituent was converted into different amide substituents in a parallel way. Tm-measurements showed no dramatic differences in both, thermal affinity and mismatch discrimination, compared to unmodified oligonucleotides. The post-synthetic modification of the carboxymethyl substituent allows in principle for a parallel preparation of a library of oligonucleotides carrying diverse substituents at C(6'). In addition, functional groups can be placed into unique positions in a DNA double helix.

Vibrational Relaxation of N2O (v2) by Atomic Oxygen Measured by Tunable Diode Laser Absorption Spectroscopy

Through the use of Transient Diode Laser Absorption Spectroscopy (TDLAS), the rate coefficient for the vibrational relaxation of N2O (ν2) by O(3P) at room temperature (32 ºC)) was determined to be (1.51 ± 0.11)x10-12 cm3molecule-1sec-1. A Q-switched, frequency quadrupled (266 nm) Nd:YAG laser pulse was used as the pump for this experiment. This pulse caused the photodissociation of O3 into O2 and O atoms.Excited oxygen (O(1D)) was collisionally quenched to ground state (O(3P)) by Ar and/or Xe. Photodissociation also caused a temperature jump within the system, exciting the ν2 state of N2O molecules. Population in the ν2 state was monitored through a TDLASobservation of a ν3 transition. Data were fit using a Visual Fortran 6.0 Global Fitting program. Analysis of room temperature data taken using only Ar to quench O atoms to the ground state gave the same rate coefficient as analysis of data taken using an Ar/Xe mixture, suggesting Ar alone is a sufficient bath gas. Experimentation was alsoperformed at -27 ºC and -82 ºC for a temperature dependence analysis. A linear regression analysis gave a rate coefficient dependence on temperature of ... for the rate coefficient of the vibrational relaxation of N2O (ν2) by atomic oxygen.

PolySynthesis 6.0 -- bicentennial edition

Even 197 years after its introduction, the notion of polysynthesis remains one of the most intriguing and controversial tools in the (morphological) typologist's toolbox. Several --occasionally contradictory--definitions have been proposed, employed for various purposes, and debated to this very day, but neither practitioners nor theoreticians have reached a comfortable level of consensus regarding its most effective and efficient form yet. The present talk maps the evolution of the notion, discusses its usefulness, and contends that the tool can be made better by updating it minimally with respect to its form and substantially with respect to its conceptual foundations. The former aspect of the update consists of making the notion more precise via explicit qualification; the latter bears relation to our arguably problematic understanding of the pairs lexical vs. grammatical and word vs. clause.

Gazophylacium medico-physicum, oder, Schatz-Kammer medicinisch- und natürlicher Dinge : in welcher alle medicinische Kunst-Wörter, (2) inn- und ëusserliche Kranckheiten, nebst derselben Geness-Mitteln, (3) alle Mineralien, Metalle, Ertzte, Erden, (4) zur Medicin gehörige fremdbe und einheimische Thiere, (5) Kräuter, Blumen, Saamen, Säffte, Oele, Hartzte, &c. : (6) alle rare Specereyen und Materialien, und (7) viel curiöse zur Mechanic gehörige Kunft-Griffe, in einer richtigen Lateinischen Alphabet-Ordnung auf das deutlichste erklähret, vorgestellet, und mit einem nöthigen Register versehen werden /

Title in red and black, head- and tail-pieces, initials.