Bright dipolar Bose-Einstein-condensate soliton mobile in a direction perpendicular to polarization

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Use of uniform designs in combination with neural networks for viral infection process development

This work aimed to compare the predictive capacity of empirical models, based on the uniform design utilization combined to artificial neural networks with respect to classical factorial designs in bioprocess, using as example the rabies virus replication in BHK-21 cells. The viral infection process parameters under study were temperature (34°C, 37°C), multiplicity of infection (0.04, 0.07, 0.1), times of infection, and harvest (24, 48, 72 hours) and the monitored output parameter was viral production. A multilevel factorial experimental design was performed for the study of this system. Fractions of this experimental approach (18, 24, 30, 36 and 42 runs), defined according uniform designs, were used as alternative for modelling through artificial neural network and thereafter an output variable optimization was carried out by means of genetic algorithm methodology. Model prediction capacities for all uniform design approaches under study were better than that found for classical factorial design approach. It was demonstrated that uniform design in combination with artificial neural network could be an efficient experimental approach for modelling complex bioprocess like viral production. For the present study case, 67% of experimental resources were saved when compared to a classical factorial design approach. In the near future, this strategy could replace the established factorial designs used in the bioprocess development activities performed within biopharmaceutical organizations because of the improvements gained in the economics of experimentation that do not sacrifice the quality of decisions.

"Experimental and computational approaches to historical masonry structures: A study in the direction of filling the gap"

The assessment of historical structures is a significant need for the next generations, as historical monuments represent the community’s identity and have an important cultural value to society. Most of historical structures built by using masonry which is one of the oldest and most common construction materials used in the building sector since the ancient time. Also it is considered a complex material, as it is a composition of brick units and mortar, which affects the structural performance of the building by having different mechanical behaviour with respect to different geometry and qualities given by the components.

The Jews of Philadelphia : their history from the earliest settlements to the present time. A record of events and institutions, and of leading members of the Jewish community in every sphere of activity

Henry Samuel Morais

A soft Take off in the direction of "Bologna"

In the 2009-10 year ten new degrees have begun to be taught at the UPM (Universidad Politécnica de Madrid), which is the first group of degrees that this University will offer within the framework of the EHEA (European Higher Education Area). One of these is the Building Engineering Degree, which was implemented in September 2009 in the EUATM (Escuela de Arquitectura Técnica de Madrid). It is heir to the former 'Arquitecto Técnico' degree that will become extinct as the new degree is successively implemented. This paper unveils the strategy that the EUATM management staff has designed and is developing, so that the complex process that involves the incorporation of our School into the model of 'Bologna', takes place smoothly and with guaranteed success

Branch migration during Rad51-promoted strand exchange proceeds in either direction

The Saccharomyces cerevisiae Rad51 protein is important for genetic recombination and repair of DNA double-strand breaks in vivo and can promote strand exchange between linear double-stranded DNA and circular single-stranded DNA in vitro. However, unlike Escherichia coli RecA, Rad51 requires an overhanging complementary 3′ or 5′ end to initiate strand exchange; given that fact, we previously surmised that the fully exchanged molecules resulted from branch migration in either direction depending on which type of end initiated the joint molecule. Our present experiments confirm that branch migration proceeds in either direction, the polarity depending on whether a 3′ or 5′ end initiates the joint molecules. Furthermore, heteroduplex DNA is formed rapidly, first at the overhanging end of the linear double-stranded DNA’s complementary strand and then more slowly by progressive lengthening of the heteroduplex region until strand exchange is complete. Although joint molecule formation occurs equally efficiently when initiated with a 3′ or 5′ overhanging end, branch migration proceeds more rapidly when it is initiated by an overhanging 3′ end, i.e., in the 5′ to 3′ direction with respect to the single-stranded DNA.

There is a tyrant in every country.

A novel.

A practical treatise on the law of tolls and customs, as well those payable in the City of Dublin as in every city, corporate town, fair and market in Ireland.

To which is added an appendix comprising all the Acts of Parliament.

Hand book of practical receipts, or Useful hints in every day life /

Includes index.

Protestantism; a study in the direction of religious truth and Christian unity.

"Explanatory index of authors cited," p. [433]-436.

Landmarks of Canada : What art has done for Canadian history; a guide to the J. Ross Robertson historical collection in the Public reference library, Toronto, Canada. This catalogue of the collection covers three thousand seven hundred illustrations and includes originals and reproductions in every form of art of all known pictures in connection with Canadian history from the landing of Wolfe at Louisburg in 1758 to the present time /

Includes brief biographical sketches of the subjects of the portraits in the collection.

Earth, sea and sky, or, Marvels of the universe : being a full and graphic description of all that is wonderful in every continent of the globe, in the world of waters and the starry heavens; containing thrilling adventures on land and sea ...; embracing the striking physical features of the earth, the peculiar characteristics of the human race, of animals, birds, insects, etc., including a vivid description of the Atlantic, Pacific and Indian oceans and of the polar seas ...; together with the amazing phenomena of the solar and starry systems; the whole comprising a vast treasury of all that is marvelous and wonderful in the earth, sea, air, and skies /

Binding: blue cover, intricate illustrations in red and gilt on front cover and spine, marbled edges, floral endpapers