The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

A 145-kDa tyrosine-phosphorylated protein that becomes associated with Shc in response to multiple cytokines has been purified from the murine hemopoietic cell line B6SUtA1. Amino acid sequence data were used to clone the cDNA encoding this protein from a B6SUtA1 library. The predicted amino acid sequence encodes a unique protein containing an N-terminal src homology 2 domain, two consensus sequences that are targets for phosphotyrosine binding domains, a proline-rich region, and two motifs highly conserved among inositol polyphosphate 5-phosphatases. Cell lysates immunoprecipitated with antiserum to this protein exhibited both phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate polyphosphate 5-phosphatase activity. This novel signal transduction intermediate may serve to modulate both Ras and inositol signaling pathways. Based on its properties, we suggest the 145-kDa protein be called SHIP for SH2-containing inositol phosphatase.

Protect labor : an address to the working men by the editor of "America" ; to which are appended statements showing the increase of manufacturing industry and wealth under a protective tariff, rates of wages in Europe as compared with the United States, etc. /

Mode of access: Internet.

The antiquities of Palmyra : containing the history of the city and its emperors from its foundation to the present time : with an appendix of critical observations on the names, religion, and government of the country, and a commentary on the inscriptions lately found there.

Errata, last leaf.

The history and antiquities of the cathedral church of Worcester: illustrated by a series of engravings of views, elevations, plans, and details of that edifice: including an architectural description of the church; and biographical anecdotes of the bishops and of other eminent persons connected with the cathedral.

Includes index.

Antigua and the Antiguans: a full account of the colony and its inhabitants from the time of the Caribs to the present day, interspersed with anecdotes and legends. Also, an impartial view of slavery and the free labour systems; the statistics of the island, and biographical notices of the principal families ...

Halkett and Laing, following a passing reference to this work in Notes and queries, March 12, 1852, p. 259, ascribe the authorship to "Mrs. Flannigan". and they are followed by Cushing. V. L. Oliver, however, in his History of the island of Antigua, London, 1894-99, v. 1, p. iv. attributes the work to "Mrs. Lanaghan".

An exposition of the practice of affusing cold water on the surface of the body, as a remedy for the cure of fever; to which are added, remarks on the effects of cold drink, and of gestation in the open air in certain conditions of that disease.

Mode of access: Internet.

The Newtonian system of philosophy : adapted to the capacities of young ladies and gentlemen, and familiarized and made entertaining, by objects with which they are intimately acquainted : being the substance of six letters, read to a select company of friends /

Cf. Roscoe, S. Newbery, J348(8)

An historical account of the life and reign of David, King of Israel. Interspersed with various conjectures, digressions and disquisitions. In which (among other things) Mr. Bayle's criticisms, upon the conduct and character of that prince, are fully considered.

Mode of access: Internet.

Practical observations on the radix rhataniae, or rhatany root, a product of Peru : containing an account of its sensible qualities, it powers as a tonic or stomachic medicine, the various forms in which it may be employed, and the most respectable testimonies in its favor as superior to the Peruvian bark in all cases that require the use of a strengthening medicine ; to which are added, directions for the use of the phosphate and oxyphosphate of iron in cancer, etc. /

Mode of access: Internet.

Biographia dramatica : or, A companion to the playhouse containing historical and critical memoirs, and original anecdotes of British and Irish dramatic writers from the commencement of our theatrical exhibitions ; among whom are some of the most celebrated actors: also an alphabetical account, and chronological lists, of their works, the dates when printed and observations on their merits: together with an introductory view of the rise and progress of the British stage, originally compiled to the year 1764 /

First edition published anonymously, 1764, under the title "The companion to the playhouse"; 2d ed., by I. Reed, 1782, under present title.

Neuropathology of Basal Ganglia and its role in the Parkinsonian syndromes with special reference to the Globus pallidus

The globus pallidus, together with the striatum (caudate nucleus and putamen), substantia nigra, nucleus accumbens, and subthalamic nucleus constitute the basal ganglia, a group of nuclei which act as a single functional unit. The basal ganglia have extensive connections to the cerebral cortex and thalamus and exert control over a variety of functions including voluntary motor control, procedural learning, and motivation. The action of the globus pallidus is primarily inhibitory and balances the excitatory influence of other areas of the brain such as the cerebral cortex and cerebellum. Neuropathological changes affecting the basal ganglia play a significant role in the clinical signs and symptoms observed in the ‘parkinsonian syndromes’ viz., Parkinson’s disease (PD), progressive supranuclear palsy (PSP), dementia with Lewy bodies (DLB), multiple system atrophy (MSA), and corticobasal degeneration (CBD). There is increasing evidence that different regions of the basal ganglia are differentially affected in these disorders. Hence, in all parkinsonian disorders and especially PD, there is significant pathology affecting the substantia nigra and its dopamine projection to the striatum. However, in PSP and MSA, the globus pallidus is also frequently affected while in DLB and CBD, whereas the caudate nucleus and/or putamen are affected, the globus pallidus is often spared. This chapter reviews the functional pathways of the basal ganglia, with special reference to the globus pallidus, and the role that differential pathology in these regions may play in the movement disorders characteristic of the parkinsonian syndromes.

Miami-Dade Health Department to Move to Florida International University , Model Clinic to Work with Medical, Public Health and Nursing Faculty

Press Release from Florida International University 's Office of Media Relations on the Miami-Dade Health Department's agreement with Florida International University to relocate its department to Florida International University 's University Park campus.

Biomarkers of metabolic syndrome and its relationship with the zinc nutritional status in obese women

Introduction: Obesity is a chronic disease that induces risk factors for metabolic syndrome and, is associated with disturbances in the metabolism of the zinc. Therefore, the aim of this study was to investigate the existence of relationship between the biomarkers of metabolic syndrome and the zinc nutricional status in obese women. Method: Seventy-three premenopausal women, aged between 20 and 50 years, were divided into two groups: case group, composed of obese (n = 37) and control group, composed of no obese (n = 36). The assessment of the body mass index and waist circumference were carried out using anthropometric measurements. The plasmatic and erythrocytary zinc were analyzed by method atomic absorption spectrophotometry (lambda=213.9 nm). Results: In the study, body mass index and waist circumference were higher in obese women than control group (p < 0.05). The mean plasmatic zinc was 72.2 +/- 9.0 mu g/dl in obese women and 73.4 +/- 8.5 mu g/dl in control group (p > 0.05). The mean erythrocytary zinc was 36.4 +/- 15.0 mu g/gHb and 45.4 +/- 14.3 mu g/gHb in the obese and controls, respectively (p < 0.05). Regression analysis showed that the body mass index (t=-2.85) and waist circumference (t=-2.37) have a negative relationship only with the erythrocytary zinc (R(2)=0.32, p < 0.05). Conclusions: The study shows that there are alterations in biochemical parameters of zinc in obese women, with low zinc concentrations in erythrocytes. Regression analysis demonstrates that the erythrocytary zinc is influenced by biomarkers of the metabolic syndrome, presenting an inverse relationship with the waist circumference and body mass index.

Immunohistochemical evaluation of macrophage activity and its relationship with apoptotic cell death in the polar forms of leprosy

The objective of the present study was to investigate the correlation between macrophage activity and apoptosis in the polar forms of leprosy because the immunopathological phenomena involved in these forms are still poorly understood For this purpose, 29 skin biopsy samples obtained from patients with the polar forms of leprosy were analyzed. Macrophage activity and apoptosis were evaluated by immunohistochemistry using lysozyme, CD68, iNOS and caspase 3 as markers The nonparametric Mann-Whitney test and Spearman`s linear correlation test were used for statistical analysis The results suggest that the apoptosis rate is under the direct influence of macrophage activity in lesions of patients with the tuberculoid form In contrast, in lepromatous lesions other factors seem to induce programmed cell death, possibly TGF-beta. Further studies are necessary to identify additional factors involved in the immunopathogenesis of leprosy. (C) 2010 Elsevier Ltd. All rights reserved

Using demand response to deal with unexpected low wind power generation in the context of smart grid

Demand response is assumed an essential resource to fully achieve the smart grids operating benefits, namely in the context of competitive markets. Some advantages of Demand Response (DR) programs and of smart grids can only be achieved through the implementation of Real Time Pricing (RTP). The integration of the expected increasing amounts of distributed energy resources, as well as new players, requires new approaches for the changing operation of power systems. The methodology proposed aims the minimization of the operation costs in a smart grid operated by a virtual power player. It is especially useful when actual and day ahead wind forecast differ significantly. When facing lower wind power generation than expected, RTP is used in order to minimize the impacts of such wind availability change. The proposed model application is here illustrated using the scenario of a special wind availability reduction day in the Portuguese power system (8th February 2012).