Dystopian fiction for young people: Instructive tales of resilience

The rise and popularity of dystopian fiction in recent years is quite marked and critics often attribute such high sales of books and box office as being linked to the impact September 11 has had on the world, especially in the United States. While the events of September 11, 2001 saw a heightened anxiety by nations and their citizens about the fear and threat of terrorism – an anxiety which is paradoxically lowered and raised by increased surveillance practices, security checks and warnings – other changes since the last stages of the twentieth century have also raised concerns and anxieties. In this paper I use examples of Young Adult (YA) dystopian fiction to illustrate the potential these texts have for providing their readers with alternative ways of thinking about the challenges that others face and their capacity for resilience.

Imaging cellular signalling: many `moving tales' in MAP kinase odyssey

Cellular signalling events are at the core of every adaptive response. Signalling events link environmental changes to physiological responses, consequently allowing cellular and organismal sustenance and survival. Classical approaches to study cellular signalling have relied on a variety of cell disruptive techniques which yield limited kinetic information, while the underlying events are much more complex. In this article, we discuss how modern live cell imaging microscopy has found increasing utilization in revealing spatio temporal dynamics of various signalling pathways. Utilizing the well studied mitogen-activated protein kinase (MAPK) signalling cascade as a template, the design, construction and utilization of `mobile' (translocation proficient) biosensors, suitable for studying MAPK signalling in living cells are described in detail. Experimental setup and results obtained from these biosensors, based on different proteins involved in the MAPK signalling cascade, have been described along with the setup of a microscope optimal for live cell imaging applications. Utilizing the ability to activate or deactivate signalling pathways using defined activators and specific pharmacological inhibitors, we also show how these sensors can yield unique spatial and temporal kinetic information of signalling in living cells.

Imaging cellular signalling: many `moving tales' in MAP kinase odyssey

Cellular signalling events are at the core of every adaptive response. Signalling events link environmental changes to physiological responses, consequently allowing cellular and organismal sustenance and survival. Classical approaches to study cellular signalling have relied on a variety of cell disruptive techniques which yield limited kinetic information, while the underlying events are much more complex. In this article, we discuss how modern live cell imaging microscopy has found increasing utilization in revealing spatio temporal dynamics of various signalling pathways. Utilizing the well studied mitogen-activated protein kinase (MAPK) signalling cascade as a template, the design, construction and utilization of `mobile' (translocation proficient) biosensors, suitable for studying MAPK signalling in living cells are described in detail. Experimental setup and results obtained from these biosensors, based on different proteins involved in the MAPK signalling cascade, have been described along with the setup of a microscope optimal for live cell imaging applications. Utilizing the ability to activate or deactivate signalling pathways using defined activators and specific pharmacological inhibitors, we also show how these sensors can yield unique spatial and temporal kinetic information of signalling in living cells.

Inconstitucionalidad de la ley argentina 26.618 de 2010 : su reforma. El matrimonio es un bien jurídico exclusivo del varón y la mujer, como tales. En consecuencia, es indisponible por el Estado.

Resumen: El presente artículo presenta las razones jurídicas que fundan la inconstitucionalidad de la ley argentina 26.618 de legalización de las uniones de personas del mismo sexo. Parte del reconocimiento de la igual dignidad esencial de todas las personas y analiza luego la reforma del matrimonio civil dispuesto por la ley 26.618 y la necesidad de reglamentación previa y específica del vínculo filiatorio y de parentesco por adopción y la improcedencia de la aplicación de las técnicas de procreación asistida en las uniones homosexuales o lésbicas. Señala cómo esta legislación afecta a terceros: al menor de edad en desamparo familiar, a la persona por nacer y, también, al matrimonio, a la familia y a la sociedad. El desarrollo presenta los argumentos por los cuales se sostiene que esta ley ha hecho una extensión irrazonable del nombre de matrimonio. También se cuestiona la “cláusula complementaria” prevista por la ley, que evidencia el abuso cometido y la imposibilidad de legislar sin lógica. Considera la actuación de los legisladores y la violación de lo anticipado en las respectivas plataformas electorales y señala que el matrimonio es una realidad anterior al derecho positivo. Finaliza con reflexiones sobre el límite objetivo que surge de la realidad y el riesgo caos social y jurídico-político y la necesidad de derogación de la ley 26.618.

Mission tales in the days of the dons, by Mrs. A.S.C. Forbes ... with nine full page illustrations and decorative drawings, by Langdon Smith.

http://www.archive.org/details/missiontalesday00forbrich

Joining the `Crusade against the Giants': Keir Hardie's Fairy Tales and The Socialist Child Reader

This article focuses on Keir Hardie's forgotten fiction and journalism for children, published in his paper The Labour Leader during the 1890s. It argues that Hardie's dialogue with child correspondents was shaped by a socialist periodical culture that redefined reading as a communal, political activity. Relating Hardie's appropriation of fantasy to that of a fellow socialist editor, John Trevor, the article examines the fairy tale as a propaganda tool in the process of `making socialists', but also questions the model of child readers as passive consumers, arguing that young readers were both empowered and controlled by Hardie's journalistic strategies.

“Telling Tales About Men: Conceptions of Conscientious Objectors to Military Service in the First World War”

Review