743 resultados para Steedman, Carolyn


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ResumenAnte la muy atinada iniciativa de reconocer mediante un número especial de la Revista de Historia la sobresaliente obra académica de la profesora emérita Carolyn Hall, cabe hacer referencia por supuesto a su producción intelectual, pero también a su labor como mentora y maestra, incluso a pesar de sí misma. También son pertinentes ciertas facetas de su personalidad, siempre exigente, desinteresada en la popularidad fácil, e incapaz de claudicar, pero igualmente empeñada en mostrar a sus estudiantes y colegas que era posible y necesario, siempre, mejorar. Quienes además de ser sus alumnos y compañeros de labores hemos tenido la oportunidad de conocerla personalmente, apreciamos una calidez humana que se expresa más fácilmente fuera del salón de clase o de reunión, en su hospitalaria acogida, en la charla informal y en los momentos difíciles de la vida.

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Introducción La Escuela de Historia de la Universidad Nacional, nos solicitó una tarea académico titánico: comentar este nuevo aporte científico de la Dra. Carolyn Hall. Este estimulo formal inicial fue redoblado al penetrar en la lectura de una obra enjundiosa, pletórica de talento, rigor, disciplina y muchas, muchísimas horas de trabajo callado pero productivo. Cabe reconocer a la autora un profundo amor por Costa Rica, ya que quien hurga en las raíces de  una formación social, percibe como durante siglos se transforma en otra. Las observaciones críticas que incluye este comentario, son pinceladas menores, ante la envergadura y dimensión de l obra de la Dra. Hall.

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El café y el Desarrollo histórico-geográfico de Costa Rica

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The Structural Genomics Consortium (SGC) and its clinical, industry and disease-foundation partners are launching open-source preclinical translational medicine studies.

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Study Design. A multicenter, randomized controlled trial with unblinded treatment and blinded outcome assessment was conducted. The treatment period was 6 weeks with follow-up assessment after treatment, then at 3, 6, and 12 months. Objectives. To determine the effectiveness of manipulative therapy and a low-load exercise program for cervicogenic headache when used alone and in combination, as compared with a control group. Summary of Background Data. Headaches arising from cervical musculoskeletal disorders are common. Conservative therapies are recommended as the first treatment of choice. Evidence for the effectiveness of manipulative therapy is inconclusive and available only for the short term. There is no evidence for exercise, and no study has investigated the effect of combined therapies for cervicogenic headache. Methods. In this study, 200 participants who met the diagnostic criteria for cervicogenic headache were randomized into four groups: manipulative therapy group, exercise therapy group, combined therapy group, and a control group. The primary outcome was a change in headache frequency. Other outcomes included changes in headache intensity and duration, the Northwick Park Neck Pain Index, medication intake, and patient satisfaction. Physical outcomes included pain on neck movement, upper cervical joint tenderness, a craniocervical flexion muscle test, and a photographic measure of posture. Results. There were no differences in headache-related and demographic characteristics between the groups at baseline. The loss to follow-up evaluation was 3.5%. At the 12-month follow-up assessment, both manipulative therapy and specific exercise had significantly reduced headache frequency and intensity, and the neck pain and effects were maintained (P < 0.05 for all). The combined therapies was not significantly superior to either therapy alone, but 10% more patients gained relief with the combination. Effect sizes were at least moderate and clinically relevant. Conclusion. Manipulative therapy and exercise can reduce the symptoms of cervicogenic headache, and the effects are maintained.

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S100A8 (also known as CP10 or MRP8) was the first member of the S100 family of calcium-binding proteins shown to be chemotactic for myeloid cells. The gene is expressed together with its dimerization partner S100A9 during myelopoiesis in the fetal liver and in adult bone marrow as well as in mature granulocytes. In this paper we show that S100A8 mRNA is expressed without S100A9 mRNA between 6.5 and 8.5 days postcoitum within fetal cells infiltrating the deciduum in the vicinity of the ectoplacental cone. Targeted disruption of the S100A8 gene caused rapid and synchronous embryo resorption by day 9.5 of development in 100% of homozygous null embryos. Until this point there was no evidence of developmental delay in S100A8(-/-) embryos and decidualization was normal. The results of PCR genotyping around 7.5-8.5 days postcoitum suggest that the null embryos are infiltrated with maternal cells before overt signs of resorption. This work is the first evidence for nonredundant function of a member of the S100 gene family and implies a role in prevention of maternal rejection of the implanting embryo. The S100A8 null provides a new model for studying fetal-maternal interactions during implantation.