999 resultados para SH-5
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Oxidative stress and mitochondrial impairment are essential in the ischemic stroke cascade and eventually lead to tissue injury. C-Phycocyanin (C-PC) has previously been shown to have strong antioxidant and neuroprotective actions. In the present study, we assessed the effects of C-PC on oxidative injury induced by tert-butylhydroperoxide (t-BOOH) in SH-SY5Y neuronal cells, on transient ischemia in rat retinas, and in the calcium/phosphate-induced impairment of isolated rat brain mitochondria (RBM). In SH-SY5Y cells, t-BOOH induced a significant reduction of cell viability as assessed by an MTT assay, and the reduction was effectively prevented by treatment with C-PC in the low micromolar concentration range. Transient ischemia in rat retinas was induced by increasing the intraocular pressure to 120 mmHg for 45 min, which was followed by 15 min of reperfusion. This event resulted in a cell density reduction to lower than 50% in the inner nuclear layer (INL), which was significantly prevented by the intraocular pre-treatment with C-PC for 15 min. In the RBM exposed to 3 mM phosphate and/or 100 mu M Ca2+, C-PC prevented in the low micromolar concentration range, the mitochondrial permeability transition as assessed by mitochondrial swelling, the membrane potential dissipation, the increase of reactive oxygen species levels and the release of the pro-apoptotic cytochrome c. In addition, C-PC displayed a strong inhibitory effect against an electrochemically-generated Fenton reaction. Therefore, C-PC is a potential neuroprotective agent against ischemic stroke, resulting in reduced neuronal oxidative injury and the protection of mitochondria from impairment. (C) 2012 Elsevier Inc. All rights reserved.
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unṭer der red. funem ... A. Ṿ. Mishulin. Yidish M. Iṭḳoviṭsh
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Author's own abridgement of his longer commentary on Moroccan sufi Ibn Mashīsh's prayer book known as Ṣalawāt. Longer version is titled: Rawḍāt al-ʻarshīyah fī al-kalām ʻala al-Ṣalawāt al-Mashīshīyah.
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بسم الله الرحمن الرحيم فهو حبي اكفي الحمد لله الملك العزيز في ملكه واقتذاره الذي ملك الوجود يقوته واوجد بارادته واختياره... :Incipit
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Title from caption (fol. 1v).
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Written in two columns, 14 lines per page, in a divani script in black ink, framed within double golden and blue lines. With catchwords on the verso of each leaf.
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Written in several hands, in one column, 23-24 lines per page, in black rubricated in red.
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Written in one column, 19 lines per page, in black.
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Cream laid paper. 20 x 13 cm. (16 x 8.5 cm.).
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Title from caption.
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Pīr Imām Shāh.
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Pīr Ṣadr ad-Dīn, Pīr Imām Shāh.
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Mikaeshi: 0.5 leaves ; preface (jo): 1.5 leaves ; main text (honbun): 22 leaves ; advertisement (kōkoku): 1 leaf.