323 resultados para SCM


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It is challenging to teach supply chain management (SCM) practices and technologies to tertiary students. This is because the back-end and highly dynamic processes can be difficult to visualise and because many students only have experience as a consumer. This paper reports the authors' experiences using a variety of multimedia and interactive enhancements we have used with our SCM learning materials: SCM business simulations; online learning modules with interactive games; and multimedia resources such as videos and animations. The paper also provides an overview of the challenges faced using these approaches, which gives rise to a number of future research opportunities. It also argues that these approaches can support educators with any epistemological view of learning. The paper makes a significant contribution because there has been little if any research into the use of these approaches in SCM education.

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The success of supply chain management (SCM) practices often depends on small firms in the supply chain adopting these practices, yet they are often reluctant to do so. The existing literature mostly explores SCM adoption barriers rather than approaches to encourage adoption. This paper argues that an educational perspective has promise, and proposes a research agenda which should guide future studies by all researchers studying small firm SCM up-take. The agenda encompasses the diversity of small firms, the major educational players, appropriate types of education approaches and the theoretical framework to underpin this research. The paper then gives an example of how this research agenda can be applied to a specific research project which will explore the impact of the Supply Chain Knowledge Centre (SCKC), a state of the art SCM education facility developed by GS1 Australia, on small firm SCM up-take.

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O presente estudo trata do assunto Microcrédito e pretende verificar a viabilidade financeira da criação de uma Sociedade de Crédito ao Microempreendedor – SCM. As entidades de microcrédito existentes são do tipo Organizações Não Governamentais - ONGs, Organizações da Sociedade Civil de Interesse Público - OSCIPs, e SCM. O estudo com base na SCM foi escolhido em função de ser uma instituição ainda não conhecida no Rio Grande do Sul, e por seu modelo tampouco ter sido testado no Estado. Mediante um estudo de caso, pretende-se ainda identificar a forma de atuação de duas instituições de microcrédito existentes. O estudo de caso foi realizado com as instituições CEAPE/RS Ana Terra e Portosol, onde foi realizada uma pesquisa exploratória com base em teoria conhecida, entrevistas e revisão de documentos dessas instituições. Os resultados foram analisados e apresentados no decorrer do trabalho. Com as informações colhidas foi realizada também uma projeção financeira de uma SCM, e comparados os resultados com as duas instituições estudadas. Nas considerações finais foram levantadas e apresentadas algumas inferências, proposições e sugestões sobre os resultados do estudo que podem ajudar o leitor a entender melhor a realidade e a viabilidade financeira de uma SCM.

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Attention has recently been drawn to Enterococcus faecium because of an increasing number of nosocomial infections caused by this species and its resistance to multiple antibacterial agents. However, relatively little is known about the pathogenic determinants of this organism. We have previously identified a cell-wall-anchored collagen adhesin, Acm, produced by some isolates of E. faecium, and a secreted antigen, SagA, exhibiting broad-spectrum binding to extracellular matrix proteins. Here, we analysed the draft genome of strain TX0016 for potential microbial surface components recognizing adhesive matrix molecules (MSCRAMMs). Genome-based bioinformatics identified 22 predicted cell-wall-anchored E. faecium surface proteins (Fms), of which 15 (including Acm) had characteristics typical of MSCRAMMs, including predicted folding into a modular architecture with multiple immunoglobulin-like domains. Functional characterization of one [Fms10; redesignated second collagen adhesin of E. faecium (Scm)] revealed that recombinant Scm(65) (A- and B-domains) and Scm(36) (A-domain) bound to collagen type V efficiently in a concentration-dependent manner, bound considerably less to collagen type I and fibrinogen, and differed from Acm in their binding specificities to collagen types IV and V. Results from far-UV circular dichroism measurements of recombinant Scm(36) and of Acm(37) indicated that these proteins were rich in beta-sheets, supporting our folding predictions. Whole-cell ELISA and FACS analyses unambiguously demonstrated surface expression of Scm in most E. faecium isolates. Strikingly, 11 of the 15 predicted MSCRAMMs clustered in four loci, each with a class C sortase gene; nine of these showed similarity to Enterococcus faecalis Ebp pilus subunits and also contained motifs essential for pilus assembly. Antibodies against one of the predicted major pilus proteins, Fms9 (redesignated EbpC(fm)), detected a 'ladder' pattern of high-molecular-mass protein bands in a Western blot analysis of cell surface extracts from E. faecium, suggesting that EbpC(fm) is polymerized into a pilus structure. Further analysis of the transcripts of the corresponding gene cluster indicated that fms1 (ebpA(fm)), fms5 (ebpB(fm)) and ebpC(fm) are co-transcribed, a result consistent with those for pilus-encoding gene clusters of other Gram-positive bacteria. All 15 genes occurred frequently in 30 clinically derived diverse E. faecium isolates tested. The common occurrence of MSCRAMM- and pilus-encoding genes and the presence of a second collagen-binding protein may have important implications for our understanding of this emerging pathogen.

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This article deals with a number of supply chain management (SCM) issues: SCM’s “Big Idea” – integration, Divergence of Theory and Practice - the limitations of “hard-wiring”, The “Human Chain”, The Way Forward – asking the right question?

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Any meaningful attempt to eliminate waste and improve cost competitiveness in the Irish packaging sector must have a strong focus on how the supply chain is designed and managed.