Relazione del pio istituto di S. Michele a Ripa Grande, eretto dalla santa memoria di PP. Innocenzo XII.

Preface signed: Giuseppe Vai, segretario e prelato deputato.

Un inédit de saint Anselme? : le traité De unitate divinae essentiae et pluralitate creaturarum d'après Jean de Ripa /

"Le manuscrit B. N. lat. 15.369 nous fournira notre texte de base." - p. 16.

Some account of the Cistercian Priory of Ripa Mola, in a letter to the Secretary of the Antiq.Soc.

[Bookplate of Henry B.Beaufoy.]

WHO comparative evaluation of serologic assays for Chagas disease

Evaluation of commercially available test kits for Chagas disease for use in blood bank screening is difficult due to a lack of large and well-characterized specimen panels. This study presents a collaborative effort of Latin American blood centers and the World Health Organization (WHO) to establish such a panel. A total of 437 specimens, from 10 countries were collected and sent to the WHO Collaborating Center in Sao Paulo and used to evaluate 19 screening assays during 2001 through 2005. Specimens were assigned a positive or negative status based on concordant results in at least three of the four confirmatory assays (indirect immunofluorescence, Western blot, radioimmunoprecipitation assay, and recombinant immunoblot). Of the 437 specimens, 168 (39%) were characterized as positive, 262 (61%) were characterized as negative, and 7 (2%) were judged inconclusive and excluded from the analysis. Sensitivity and specificity varied considerably: 88 to 100 and 60 to 100 percent, respectively. Overall, enzyme immunoassays (EIAs) performed better than the other screening assays. Four EIAs had both parameters higher than 99 percent. Of the four confirmatory assays, only the RIPA gave a 100 percent agreement with the final serologic status of the specimens. The sensitivities and specificities of at least four of the commercially available EIAs for Chagas disease are probably high enough to justify their use for single-assay screening of blood donations. Our data suggest that the majority of commercially available indirect hemagglutination assays should not be used for blood donor screening and that the RIPA could be considered a gold standard for evaluating the performance of other assays.

Frequency of platelet type versus type 2B von Willebrand disease. An international registry-based study.

Less than 50 patients are reported with platelet type von Willebrand disease (PT-VWD) worldwide. Several reports have discussed the diagnostic challenge of this disease versus the closely similar disorder type 2B VWD. However, no systematic study has evaluated this dilemma globally. Over three years, a total of 110 samples/data from eight countries were analysed. A molecular approach was utilised, analysing exon 28 of the von Willebrand factor (VWF) gene, and in mutation negative cases the platelet GP1BA gene. Our results show that 48 cases initially diagnosed as putative type 2B/PT-VWD carried exon 28 mutations consistent with type 2B VWD, 17 carried GP1BA mutations consistent with a PT-VWD diagnosis, three had other VWD types (2A and 2M) and five expressed three non-previously published exon 28 mutations. Excluding 10 unaffected family members and one acquired VWD, 26 cases did not have mutations in either genes. Based on our study, the percentage of type 2B VWD diagnosis is 44% while the percentage of misdiagnosis of PT-VWD is 15%. This is the first large international study to investigate the occurrence of PT-VWD and type 2B VWD worldwide and to evaluate DNA analysis as a diagnostic tool for a large cohort of patients. The study highlights the diagnostic limitations due to unavailability/poor application of RIPA and related tests in some centres and proposes genetic analysis as a suitable tool for the discrimination of the two disorders worldwide. Cases that are negative for both VWF and GP1BA gene mutations require further evaluation for alternative diagnoses.

Rivan kärjen jännityskomponentit

Tässä kandidaatin työssä on tutkitti miten eri jännityskomponentit käyttäytyvät rivan kärjen läheisyydessä. Työssä tutkittiin kahta eri mallia, rivallista levyä ja rivallista levyä hitsauksesta johtuvalla kulmavetäymällä. Tutkimus suoritettiin FEA-analyysin avulla. Komponenttien käyttäytymistä tutkittiin sekä veto- että taivutuskuormituksella. Tuloksissa on verrattu miten kulmavetäymä vaikuttaa komponenttien syntyyn ja miten eri kuormituksilla saadut tulokset poikkeavat toisistaan.

Breve reseña de la vigésimaprimera peregrinación de la iglesia de Querétaro al Santuario de la Madre de Dios, madre y Reina de los mexicanos María Santísima de Guadalupe en el año de 1905.

UANL