City of Elk Run Heights, June 30, 2002

City Audit Report

Radiolabeled and native antibodies and the prospect of cure of follicular lymphoma

Advanced-stage follicular lymphoma is incurable by conventional treatment. Rituximab has been introduced in various combinations with chemotherapy and has resulted in a significantly superior treatment outcome compared with chemotherapy alone. Multiple studies have also shown the efficacy of radioimmunotherapy (RIT) both as a single agent and in combination with chemotherapy. Rituximab and RIT have clearly distinct mechanisms of action, the first acting exclusively as a biological treatment, while the second acts by a combination of biologic mechanisms and radiation effects. Despite the therapeutic efficacy of both approaches, the potential exists to further improve both modalities. Repeat administrations of RIT using appropriate radioisotopes for treatment of residual disease or new targeting strategies might afford additional benefits. Unlabeled antibody treatment could potentially benefit from the combination of antibodies directed against different target antigens or combination therapy with cytokines capable of further mobilizing patients' cellular defenses. In this review, we hypothesize that the combination of an optimized biological treatment together with radiolabeled antibodies and chemotherapy early in the disease course of advanced-stage follicular lymphoma may represent the best approach to achieve prolonged disease-free survival and eventually cure.

Audit report on the City of Elk Run Heights, Iowa for the year ended June 30, 2006

Audit report on the City of Elk Run Heights, Iowa for the year ended June 30, 2006.

Audit report on the City of Elk Run Heights, Iowa for the year ended June 30, 2008

Audit report on the City of Elk Run Heights, Iowa for the year ended June 30, 2008

Audit report on the City of Windsor Heights, Iowa for the year ended June 30, 2011

Audit report on the City of Windsor Heights, Iowa for the year ended June 30, 2011

Audit report on the City of Windsor Heights, Iowa for the year ended June 30, 2012

Audit report on the City of Windsor Heights, Iowa for the year ended June 30, 2012

Audit report on the City of Elk Run Heights, Iowa for the year ended June 30, 2012

Audit report on the City of Elk Run Heights, Iowa for the year ended June 30, 2012

Audit report on the City of Windsor Heights, Iowa for the year ended June 30, 2013

Audit report on the City of Windsor Heights, Iowa for the year ended June 30, 2013

Prospect und Grund-Riss der Kayserl. Residenz-Stadt Wien mit negst anligender gegend und neuen Linien umb die Vorstädt

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