998 resultados para PDC-109


Relevância:

20.00% 20.00%

Publicador:

Resumo:

OBJECTIVES: Blunted nocturnal dip of blood pressure (BP) and reversed circadian rhythm have been described in preeclampsia (PE). Non-dipper status and preeclampsia are both associated with an increased risk of cardiovascular disease later in life. Complete recovery of BP in PE is reported to occur over a variable period of time. Twenty-four hours-ambulatory blood pressure measurement (ABPM) in the post-partum follow-up after a PE has not been described. The aim of this study was to assess 24h-ambulatory blood pressure pattern after a PE and to determine the prevalence of non-dipper status, nocturnal hypertension, white coat hypertension and masked hypertension. METHODS: This is an observational, prospective study on women who suffered from a preeclampsia. A 24h-ABPM was done 6 weeks post-partum at the Hypertension Unit of the University Hospitals of Geneva, concomitantly with a clinical and biological evaluation. RESULTS: Forty-five women were included in a preliminary analysis. Mean age was 33±6years, 57.3% were Caucasian, mean BMI before pregnancy was 24±5kg/m(2). Office and ambulatory BP are shown in Table 1. Prevalence of nocturnal hypertension was high and half of the women had no nocturnal dipping. The diagnosis of hypertension based on office BP was discordant with the diagnosis based on ABPM in 25% of women. CONCLUSIONS: The prevalence of increased nighttime BP and abnormal BP pattern is high at 6weeks post-partum in preeclamptic women. Early assessment of BP with ABPM after preeclampsia allows an early identification of women with persistent circadian abnormalities who might be at increased risk. It also provides a more accurate assessment than office BP. DISCLOSURES: A. Ditisheim: None. B. Ponte: None. G. Wuerzner: None. M. Burnier: None. M. Boulvain: None. A. Pechère-Bertschi: None.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

BACKGROUND: The counting of poorly differentiated clusters of 5 or more cancer cells lacking a gland-like structure in a tumor mass has recently been identified among the histological features predictive of poor prognosis in colorectal cancer. MAIN BODY: Poorly differentiated clusters can easily be recognized in the histological sections of colorectal cancer routinely stained with haematoxylin and eosin. Despite some limitations related to specimen fragmentation, counting can also be assessed in endoscopic biopsies. Based on the number of poorly differentiated clusters that appear under a microscopic field of a ×20 objective lens (i.e., a microscopic field with a major axis of 1 mm), colorectal cancer can be graded into malignancies as follows: tumors with <5 clusters as grade 1, tumors with 5 to 9 clusters as grade 2, and tumors with ≥10 clusters as grade 3. High poorly differentiated cluster counts are significantly associated with peri-neural and lympho-vascular invasion, the presence of nodal metastases or micrometastases, as well as shorter overall and progression free survival to colorectal cancer. CONCLUSION: The morphological aspects and clinical relevance of poorly differentiated clusters counting in colorectal cancer are discussed in this review.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

An epidemic of rice (Oryza sativa) blast occurred on cultivars Epagri 108 and 109 in the municipalities of Lagoa da Confusão and Duerê in the State of Tocantins, during the rice-growing season 1998-99. DNA fingerprinting and virulence phenotype analysis were utilized to determine the diversity of Pyricularia grisea isolates collected from these cultivars in one epidemic year. Rep-PCR analysis of isolates was done by using two primer sequences from Pot2. Two distinct fingerprint groups or lineages were identified among 53 isolates collected from nine different commercial fields. The virulence pattern of isolates retrieved from these two cultivars was analyzed in artificial inoculation tests utilizing 32 genotypes in the greenhouse. A dendrogram constructed from virulence phenotype data showed a single group considering 77% similarity level. The predominant pathotype IB-45 was represented by 47 of the 53 isolates corresponding to 83%. Four other pathotypes (IB-1, IB-9, IB-13 and IB-41) were identified at random among the isolates from these cultivars. There was no relation between rep-PCR grouping and pathotypes. The results showed that the isolates of P. grisea recovered from cultivars Epagri108 and 109 in farmers' fields had narrow phenotypic and genetic diversity. The blast outbreak on these two cultivars one year after their introduction could be attributed to the new pathotype IB-45 or its increase, which was hitherto existing in low frequency.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

kuv., 11 x 30 cm

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Tämä laadullinen sotahistorian tutkimus käsittelee ja vertailee Messerschmitt Bf-109 -konetyypin käyttöä Suomessa ja Unkarissa toisen maailmansodan aikana. Tutkimusmenetelmänä on käytetty vertailevaa (komparatiivista) aineistoanalyysia. Suomen ja Unkarin ilmavoimat ovat tutkimuksen kohdemaita, ja tutkimuksessa perehdytään Messerschmitthävittäjän käyttöperiaatteisiin, konemallin taktiseen käyttöön, sekä lentäjien koulutukseen. Lisäksi perehdytään laivueiden ja yksittäisten lentäjien taistelukertomuksien kautta siihen, millainen konemalli oli lentää ilmataisteluissa. Tutkielmassa pyritään vastaamaan pääkysymykseen: Mitkä olivat Messerschmitt Bf-109:n käyttöperiaatteet Suomen ja Unkarin ilmavoimissa toisen maailmansodan aikana? Pääkysymystä tukevat seuraavat alatutkimuskysymykset: Miten lentäjiä koulutettiin kyseiseen konetyyppiin? Miten Messerschmitthävittäjät ryhmitettiin kohdemaiden sodan ajan organisaatioissa? Mitä viholliskalustoa vastaan Messerschmitthävittäjiä käytettiin itärintamalla? Mitä eroja ja samankaltaisuuksia ilmenee Suomen ja Unkarin hävittäjätaktiikassa Messerschmitt Bf-109:n kohdalla ja miksi? Miten näissä maissa toimintaympäristöt erosivat /muistuttivat toisiaan? Tutkielman johdannossa esitellään tutkimuksen päämäärä, rajaus, tutkimuskysymykset, viitekehys sekä lyhyesti tutkimuksen aiheena oleva Messerschmitt Bf-109 -hävittäjä. Ensimmäisessä pääluvussa käsitellään Bf-109:n käyttöä Suomessa aina hävittäjähankinnasta taktiik-kaan ja koulutukseen. Toisessa pääluvussa käsitellään vastaavasti Bf-109:n käyttöä Unkarin ilmavoimissa samalla logiikalla. Johtopäätösluvussa esitellään tutkimustulokset ja johtopäätökset, joilla vastataan tutkimuskysymyksiin. Tutkimuksen tuloksina todetaan että isoimmat käyttöperiaatteelliset erot Suomen ja Unkarin välillä liittyivät hankintaan ja koulutukseen ja taistelutapaan, kun taas samankaltaisuuksia oli havaittavissa konekaluston sijoittelussa ja toimintaympäristöissä. Unkari sai geopoliittisen asemansa ansiosta enemmän tukea saksalaiselta Luftwaffe:lta, kun taas esimerkiksi varaosien saaminen Suomeen oli usein vaikeaa.