950 resultados para Otthera, Johann von, b. 1479 or 80,


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Hermann Wellesz

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Hermann Wellesz

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Hermann Wellesz

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Signatur des Originals: S 36/F11515

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Signatur des Originals: S 36/F11525

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Signatur des Originals: S 36/F11675

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Signatur des Originals: S 36/F11678

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DNA vaccines expressing herpes simplex virus type 2 (HSV-2) full-length glycoprotein D (gD), or a truncated form of HSV-2 glycoprotein B (gB) were evaluated for protective efficacy in two experimental models of HSV-2 infection. Intramuscular (i.m.) injection of mice showed that each construction induced neutralizing serum antibodies and protected the mice from lethal HSV-2 infection. Dose-titration studies showed that low doses (< or = 1 microgram) of either DNA construction induced protective immunity, and that a single immunization with the gD construction was effective. The two DNAs were then tested in a low-dosage combination in guinea pigs. Immune sera from DNA-injected animals had antibodies to both gD and gB, and virus neutralizing activity. When challenged by vaginal infection with HSV-2, the DNA-immunized animals were significantly protected from primary genital disease.

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German and French text.