ECONOMIC ANALYSIS OF THE DEMAND FOR PRESCRIPTION MEDICINE IN THE UNITED STATES

The purpose of this study was to understand the role of principle economic, sociodemographic and health status factors in determining the likelihood and volume of prescription drug use. Econometric demand regression models were developed for this purpose. Ten explanatory variables were examined: family income, coinsurance rate, age, sex, race, household head education level, size of family, health status, number of medical visits, and type of provider seen during medical visits. The economic factors (family income and coinsurance) were given special emphasis in this study.^ The National Medical Care Utilization and Expenditure Survey (NMCUES) was the data source. The sample represented the civilian, noninstitutionalized residents of the United States in 1980. The sample method used in the survey was a stratified four-stage, area probability design. The sample was comprised of 6,600 households (17,123 individuals). The weighted sample provided the population estimates used in the analysis. Five repeated interviews were conducted with each household. The household survey provided detailed information on the United States health status, pattern of health care utilization, charges for services received, and methods of payments for 1980.^ The study provided evidence that economic factors influenced the use of prescription drugs, but the use was not highly responsive to family income and coinsurance for the levels examined. The elasticities for family income ranged from -.0002 to -.013 and coinsurance ranged from -.174 to -.108. Income has a greater influence on the likelihood of prescription drug use, and coinsurance rates had an impact on the amount spent on prescription drugs. The coinsurance effect was not examined for the likelihood of drug use due to limitations in the measurement of coinsurance. Health status appeared to overwhelm any effects which may be attributed to family income or coinsurance. The likelihood of prescription drug use was highly dependent on visits to medical providers. The volume of prescription drug use was highly dependent on the health status, age, and whether or not the individual saw a general practitioner. ^

El fitness como factor determinante en el riesgo de discapacidad, su relación con la composición corporal y el estado cognitivo en población mayor institucionalizada y de vida independiente = Fitness as a determinant factor in the risk of disability, and its relationship to body composition and cognitive status in institutionalized elderly population and independent living

La condición física, o como mejor se la conoce hoy en día el “fitness”, es una variable que está cobrando gran protagonismo, especialmente desde la perspectiva de la salud. La mejora de la calidad de vida que se ha experimentado en los últimos años en las sociedades desarrolladas, conlleva un aumento de la esperanza de vida, lo que hace que cada vez más personas vivan más años. Este rápido crecimiento de la población mayor de 60 años hace que, un grupo poblacional prácticamente olvidado desde el punto de vista de la investigación científica en el campo de la actividad física y del deporte, cobre gran relevancia, con el fin de poder ayudar a alcanzar el dicho “no se trata de aportar años a la vida sino vida a lo años”. La presente memoria de Tesis Doctoral tiene como principal objetivo valorar los niveles de fitness en población mayor española, además de analizar la relación existente entre el fitness, sus condicionantes y otros aspectos de la salud, tales como la composición corporal y el estado cognitivo. Entendemos que para poder establecer futuras políticas de salud pública en relación a la actividad física y el envejecimiento activo es necesario conocer cuáles son los niveles de partida de la población mayor en España y sus condicionantes. El trabajo está basado en los datos del estudio multicéntrico EXERNET (Estudio Multi-céntrico para la Evaluación de los Niveles de Condición Física y su relación con Estilos de Vida Saludables en población mayor española no institucionalizada), así como en los datos de dos estudios, llevados a cabo en población mayor institucionalizada. Se han analizado un total de 3136 mayores de vida independiente, procedentes de 6 comunidades autónomas, y 153 mayores institucionalizados en residencias de la Comunidad de Madrid. Los principales resultados de esta tesis son los siguientes: a) Fueron establecidos los valores de referencia, así como las curvas de percentiles, para cada uno de los test de fitness, de acuerdo a la edad y al sexo, en población mayor española de vida independiente y no institucionalizada. b) Los varones obtuvieron mejores niveles de fitness que las mujeres, excepto en los test de flexibilidad; existe una tendencia a disminuir la condición física en ambos sexos a medida que la edad aumenta. c) Niveles bajos de fitness funcional fueron asociados con un aumento en la percepción de problemas. d) El nivel mínimo de fitness funcional a partir del cual los mayores perciben problemas en sus actividades de la vida diaria (AVD) es similar en ambos sexos. e) Niveles elevados de fitness fueron asociados con un menor riesgo de sufrir obesidad sarcopénica y con una mejor salud percibida en los mayores. f) Las personas mayores con obesidad sarcopénica tienen menor capacidad funcional que las personas mayores sanas. g) Niveles elevados de fuerza fueron asociados con un mejor estado cognitivo siendo el estado cognitivo la variable que más influye en el deterioro de la fuerza, incluso más que el sexo y la edad. ABSTRACT Fitness is a variable that is gaining in prominence, especially from the health perspective. Improvement of life quality that has been experienced in the last few years in developed countries, leads to an expanded life expectancy, increasing the numbers of people living longer. This population consisting of people of over 60 years, an almost forgotten population group from the point of view of scientific research in the field of physical activity and sport, is becoming increasingly important, with the main aim of helping to achieve the saying “do not only add years to life, but also add life to years”. The principal aim of the current thesis was to assess physical fitness levels in Spanish elderly people, of over 65 years, analyzing relationship between physical fitness, its determinants, and other aspects of health such as body composition and cognitive status. In order to establish further public health policies in relation to physical activity and active ageing it is necessary to identify the starting physical fitness levels of the Spanish population and their determinants. The work is based on data from the EXERNET multi-center study ("Multi-center Study for the Evaluation of Fitness levels and their relationship to Healthy Lifestyles in noninstitutionalized Spanish elderly"), and on data from two studies conducted in institutionalized elderly people: a total of 3136 non-institutionalized elderly, from 6 Regions of Spain, and 153 institutionalized elderly in nursing homes of Madrid. The main outcomes of this thesis are: a) sex- and age-specific physical fitness normative values and percentile curves for independent and non-institutionalized Spanish elderly were established. b) Greater physical fitness was present in the elderly men than in women, except for the flexibility test, and a trend toward decreased physical fitness in both sexes as their age increased. c) Lower levels of functional fitness were associated with increased perceived problems. d) The minimum functional fitness level at which older adults perceive problems in their ADLs, is similar for both sexes e) Higher levels of physical fitness were associated with a reduced risk of suffering sarcopenic obesity and better perceived health among the elderly. f) The elderly with sarcopenic obesity have lower physical functioning than healthy counterparts. g) Higher strength values were associated with better cognitive status with cognitive status being the most influencing variable in strength deterioration even more than sex and age.

Evidence for a recommended dietary allowance for vitamin C from pharmacokinetics: A comment and analysis

The current recommended dietary allowance (RDA) for vitamin C, as proposed by the Food and Nutrition Board/National Research Council in 1980 and reconfirmed in 1989, is 60 mg daily for nonsmoking adult males. Levine et al. [Levine, M., Conry-Cantilena, C., Wang, Y., Welch, R. W., Washko, P. W., et al. (1996) Proc. Natl. Acad. Sci. USA 93, 3704–3709], based on a study of vitamin C pharmacokinetics in seven healthy men, have now proposed that the RDA should be increased to 200 mg daily. I have examined, in brief, the experimental and conceptual bases for this new recommendation and its implications for public health and nutrition policy and programs. Using, for illustrative purposes only, data extracted from each of two recent dietary surveys of noninstitutionalized adult males living in households in the Netherlands and the United States, it is predicted that the prevalence of intakes inadequate to meet the individual’s own requirement would be about 96% or 84%, respectively, if the criteria of adequacy used for derivation of the 200 mg RDA are accepted. Depending upon the particular average requirement value for ascorbic acid that might be derived from their data, the proposal by Levine et al. would mean a desirable increase in mean intakes in these two populations by as much about 2- to 3-fold. Hence, before an action of this kind is to be recommended, an answer must be sought to the question whether current experimental data including the criteria selected (saturation kinetics) are adequate to establish a new set of requirements for vitamin C, which then carry such profound policy implications. This will require critical assessment of all of the available evidence emerging from laboratory, clinical, and epidemiological studies to determine whether it provides a sufficient rationale for accepting criteria of vitamin C adequacy such as those proposed by Levine et al. and the requirement estimates so derived.

Democratic governance and the rule of law : lessons from Colombia /

"Colombia has experienced conflict for decades. In the 1990s it was a paradigm of the failing state, beset with all manner of troubles: terrorism, kidnapping, murder, drug trafficking, corruption, an economic downturn of major scope, general lawlessness, and brain drain. Today the country is much safer, and the agents of violence are clearly on the defensive. Nonetheless, much work lies ahead to secure the democratic system. Security and the rule of law are fundamental to the task. As the monopoly over the legitimate use of force is established, democratic governance also needs the architecture of law: ministry of justice, courts, legislative scrutiny, law enforcement agencies, regulatory bodies, public defenders, police, correctional system, legal statutes, contracts, university level academic education to train lawyers, judges, and investigators, along with engagement with civil society to promote a culture of lawfulness. Security without the rule of law puts a society at risk of falling into a Hobbesian hell."--P. v.

Reducing Health Disparities: Medical advice and health behavior of minorities with diabetes

OBJECTIVE: to examine the relationships among reported medical advice, diabetes education, health insurance and health behavior of individuals with diabetes by race/ethnicity and gender. METHOD: Secondary analysis of data (N = 654) for adults ages > or = 21 years with diabetes acquired through the National Health and Nutrition Examination Survey (NHANES) for the years 2007-2008 comparing Black, non-Hispanics (BNH) and Mexican-Americans (MA) with White, non-Hispanics (WNH). The NHANES survey design is a stratified, multistage probability sample of the civilian noninstitutionalized U.S. population. Sample weights were applied in accordance with NHANES specifications using the complex sample module of IBM SPSS version 18. RESULTS: The findings revealed statistical significant differences in reported medical advice given. BNH [OR = 1.83 (1.16, 2.88), p = 0.013] were more likely than WNH to report being told to reduce fat or calories. Similarly, BNH [OR = 2.84 (1.45, 5.59), p = 0.005] were more likely than WNH to report that they were told to increase their physical activity. Mexican-Americans were less likely to self-monitor their blood glucose than WNH [OR = 2.70 (1.66, 4.38), p < 0.001]. There were differences by race/ethnicity for reporting receiving recent diabetes education. Black, non-Hispanics were twice as likely to report receiving diabetes education than WNH [OR = 2.29 (1.36, 3.85), p = 0.004]. Having recent diabetes education increased the likelihood of performing several diabetes self-management behaviors independent of race. CONCLUSIONS: There were significant differences in reported medical advice received for diabetes care by race/ethnicity. The results suggest ethnic variations in patient-provider communication and may be a consequence of their health beliefs, patient-provider communication as well as length of visit and access to healthcare. These findings clearly demonstrate the need for government sponsored programs, with a patient-centered approach, augmenting usual medical care for diabetes. Moreover, the results suggest that public policy is needed to require the provision of diabetes education at least every two years by public health insurance programs and recommend this provision for all private insurance companies

A Vinculação e a Auto-Estima em Jovens Não-Institucionalizados Vs. Institucionalizados

Introdução: Uma relação de vinculação segura implica a presença de um modelo representacional das figuras de vinculação como “disponíveis” e capazes de proporcionar protecção e que a qualidade dos cuidados parentais precoce é fundamental a determinar a saúde mental dos indivíduos. Se esta relação assume um enorme relevância para a saúde mental de qualquer ser humano, a institucionalização de crianças/jovens, envolvendo ameaças em termos da disponibilidade das figuras de vinculação constitui uma condição propícia para atrasos de desenvolvimento e aumento da probabilidade do desenvolvimento de sintomatologia psicopatológica. Os objectivos deste estudo passam, então, por analisar as diferenças na vinculação, mas também na auto-estima, de jovens institucionalizados vs nãoinstitucionalizados. Metodologia: A nossa amostra é constituída por 223 jovens nãoinstitucionalizados de duas escolas do Concelho de Coimbra (média de idades M=15.3; desvio-padrão, DP=1.97) e 47 jovens institucionalizados (M=15.5 DP=1.93). Tanto os jovens institucionalizados como não-institucionalizados preencheram um questionário com questões sóciodemográficas, relacionais, escolares, de saúde e bem-estar (com pequenas particularidades em algumas variáveis conforme a sub-amostra), o Inventory of Parent Attachment (IPPA) e a Rosenberg Self-Esteem Scale (RSES). A sub-amostra de jovens institucionalizados respondeu ainda a questões sobre a sua adaptação/vivência ao/no Lar. Resultados: Os rapazes da amostra não institucionalizada apresentam uma pontuação média mais elevada de auto-estima vs. raparigas. Nos jovens institucionalizados não foram encontradas diferenças de género a este nível. Não existem diferenças de género, em ambas as sub-amostras, na pontuação total do IPPA e suas dimensões. Os rapazes nãoinstitucionalizados vs. institucionalizados não divergem na pontuação média total de autoestima. O mesmo sucede com as raparigas. Ambas as sub-amostras não divergem na pontuação média total do IPPA e suas dimensões. Na amostra não-institucionalizada quer nos rapazes, quer nas raparigas não existem diferenças na pontuação total média na RSES, entre os jovens mais novos vs. mais velhos. Na amostra institucionalizada também não se verificam diferenças na pontuação total na RSES por idades. Nos jovens não institucionalizados foram encontradas diferenças na pontuação total média no IPPA (e suas dimensões, à excepção da Alienação), por idade, com os mais novos a apresentarem sempre valores médios mais elevados. Na amostra institucionalizada estas diferenças não se verificaram. Nos rapazes e raparigas da amostra não-institucionalizada verificaram-se associações significativas entre a pontuação na RSES e no IPPA e em todas as suas dimensões. O mesmo se verificou na subamostra institucionalizada. Não existe uma associação significativa entre a pertença a dada sub-amostra e a pertença ao grupo “pouco seguro” vs. “muito seguro”. Apesar de outras associações terem sido encontradas, importa reforçar as associações significativas entre a pontuação na auto-estima e na vinculação total e suas dimensões (quer nos rapazes e raparigas não-institucionalizados, como na amostra institucionalizada) e variáveis como a sintomatologia depressiva, a sintomatologia ansiosa e algumas variáveis relacionais. Discussão/Conclusão: De um modo geral parecem não existir diferenças entre jovens nãoinstitucionalizados vs. institucionalizados em termos de vinculação e de auto-estima. Porém, a uma vinculação insegura e uma menor auto-estima associam-se piores outcomes (e.g. sintomatologia depressiva) em ambas as amostras. Os profissionais trabalhando com adolescentes não-institucionalizados ou institucionalizados devem preocupar-se em avaliar a sua auto-estima e vinculação, procurando, eventualmente, nelas intervir terapeuticamente. / Introduction: It is well kown that a secure attachment relation implies the presence of representational model of the attachment figures as being available and able to provide protection and that the quality of earlier parental care is crucial in determining subjects mental health and there developmental trajectories. If this relation assumes such a big relevance to the mental health of any human being, the institutionalization of children/adolescents, even when truly needed, involving threats in terms of the availability of attachment figures constitutes a condition that might lead to developmental delays and might increase the probability of psychopathological sintomatology developing. The aims of this study are, then, to analyze if there are attachment differences and, also, in self-esteem, between a sub-sample of non-institutionalized and institutionalized adolescents. Methodology: Our sample comprises 223 adolescents non-institutionalized from two schools of Coimbra Council (mean age, M=15.3; standard deviation, SD=1.97) and 47 institutionalized adolescents (M=15.5 SD=1.93). Both sub-samples filled in a questionnaire with sociodemographic, relational, about school, health and well-being questions (with small particularities in some variables, regarding each sub-sample), the Inventory of Parent Attachment (IPPA) and the Rosenberg Self-Esteem Scale (RSES). Institutionalized adolescents also answered questions about the adaptation/life to/in the institution. Results: Boys from the non-institutionalized sub-sample present an higher self-esteem mean score vs. girls. We did not find significant gender differences in self-esteem mean score in the subsample of institutionalized adolescents. There are no gender differences, in both sub-samples, in IPPA (and all its dimensions) total score. Non-institutionalized boys vs. institutionalized boys do not differ in their self-esteem mean score. The same is valid for girls. Both subsamples do not differ in their IPPA (and all its dimensions) mean score. In the noninstitutionalized sample, either in boys, either in girls there are no differences regarding total RSES mean score, between younger (12-15 years old) and older (16-20 years old) adolescents. In the institutionalized sample there were also no differences regarding this score, by age groups. In the non-institutionalized sub-sample we found differences in IPPA total mean score (an in all its dimensions, with the exception of Alienation), by age, with younger adolescents presenting always higher mean scores. In the institutionalized sample there were no differences. Both in boys and girls from the non-institutionalized sample there were significant associations between RSES score and IPPA (and all its dimensions) score. The same result was found in the total institutionalized sample. Although other significant associations were found, we must reinforce the presence of significant associations between self-esteem score and IPPA total score (and of its dimensions) (either in boys and girls noninstitutionalized, either in the institutionalized sub-sample) and variables such as lifetime and depressive symptomatology in the last two weeks, anxious symptomatology in the last two weeks and some relational variables. Discussion/Conclusion: In general, we did not found significant differences between non-institutionalized vs. institutionalized adolescents in terms of attachment and self-esteem. However, a secure attachment and a lower self-esteem are associated with worst outcomes (e.g. depressive symptomatology) in both samples. Professionals working with adolescents, either or not institutionalized must assess their selfesteem and attachment and might, eventually, intervene on these aspects therapeutically.

Qualidade Subjetiva do Sono, Sintomas Depressivos e Sentimentos de Solidão em Idosos Institucionalizados e Não Institucionalizados

Parece existir uma associação entre solidão e uma pobre qualidade subjetiva do sono. Em reforço desta ideia, alguns estudos mostraram que os sentimentos de solidão se associam a uma menor satisfação do sono, mesmo que a sua duração não esteja diminuída. Outros mostraram que a solidão se associa a sintomas depressivos. Sabe-se que na institucionalização são frequentes os problemas de sono, depressão e solidão. No entanto, falta saber o que se passa nas respostas sociais portuguesas. Assim foram os nossos principais objetivos descrever a qualidade subjetiva do sono e analisar a intensidade dos sintomas depressivos e dos sintomas de solidão em idosos institucionalizados, comparar com uma subamostra de idosos não institucionalizados e analisar a relação entre estas variáveis nas duas subamostras. Cento e quarenta idosos, com 70 institucionalizados e 70 não institucionalizados foram emparelhados por idade, sexo, escolaridade, estado civil e sem défice cognitivo. A média de idades foi de 76,58 (DP = 6,10), sendo 104 mulheres e 36 homens. Como instrumentos para a análise utilizámos um Questionário Sociodemográfico, o Questionário sobre o Sono na Terceira Idade, o Inventário de Depressão Geriátrica e a Escala de Solidão da Universidade da Califórnia, Los Angeles. Verificou-se que os idosos institucionalizados apresentavam mais sentimentos de solidão do que os não institucionalizados. Contudo, não se verificaram diferenças entre as duas subamostras em relação aos sintomas depressivos e à qualidade subjetiva do sono. Através de uma análise correlacional verificou-se nas duas subamostras que quanto pior a qualidade subjetiva do sono mais sintomas depressivos se observavam e quanto mais sintomas depressivos, mais sentimentos de solidão. Concluímos que não houve diferenças na qualidade subjetiva do sono pelo tipo de resposta social ainda que haja mais sintomas depressivos e sintomas de solidão nos idosos institucionalizados. Não encontrámos também relação entre o sono e a solidão nos idosos institucionalizados. / There seems to be an association between loneliness and poor subjective sleep quality. In support of this idea, some studies have shown that feelings of loneliness are associated with less satisfaction sleep, even if your life is not diminished. Others have shown that loneliness is associated with depressive symptoms. It is known that in the institutionalization are frequent problems with sleeping, depression and loneliness. However, lack know what is happening in the Portuguese social responses. So were our main objectives describe the subjective quality of sleep and analyze the intensity of depressive symptoms and loneliness symptoms in institutionalized elderly, compared with a non-institutionalized elderly subsample and analyze the relationship between these variables in both subsamples. One hundred and forty older adults, with 70 institutionalized and 70 non-institutionalized were matched by age, sex, education, marital status and without cognitive impairment. The average age was 76.58 (SD = 6.10), including 104 women and 36 men. As tools for the analysis we used a sociodemographic questionnaire, the Questionnaire About Sleep in the Older Adults, Geriatric Depression Inventory and the Loneliness Scale of the University of California, Los Angeles. It was found that the institutionalized older adults had more feelings of loneliness than noninstitutionalized. However, there were no differences between the two subsamples in relation to depressive symptoms and subjective sleep quality. Through a correlational analysis it was found in the two subsamples that the worse the subjective sleep quality more depressive symptoms were observed and the more depressive symptoms, more feelings of loneliness. We concluded that there no differences in subjective sleep quality by the type of social response even though there are more depressive symptoms and symptoms of loneliness in the elderly. Also we did not find relationship between sleep and loneliness in the elderly.

Determinantes do bem-estar subjetivo na pessoa idosa

Introdução: O Bem-Estar Subjetivo, enquadrado no âmbito da intervenção da Psicologia positiva, refere-se à experiência individual e subjetiva da avaliação da vida, e inclui variáveis como a satisfação com a vida e a vivência de afetos positivos em detrimento dos afetos negativos. Considerando que o bem-estar subjetivo está associado à saúde e longevidade, o objetivo central deste estudo consiste em analisar o modo como determinadas variáveis de contexto sociodemográfico, familiar, clínico e psicossocial se revelam preditoras do bem-estar subjectivo em idosos institucionalizados versus não institucionalizados. Métodos: Realizou-se um estudo de natureza quantitativa, descritivo-correlacional e transversal, com recurso a uma amostra não probabilística, acidental e por conveniência, composta por 116 idosos, 58 não institucionalizados e 58 institucionalizados, maioritariamente do género feminino (60,3%), viúvos (42,3%), com uma média de idades de 77,73 anos (Dp=9,276). O instrumento de colheita de dados incorporou uma ficha de caraterização sociodemográfica, situacional, familiar (Escala de Apgar Familiar), clínico – funcional (Índice de Barthel) e a avaliação do Bem-Estar Subjetivo (Escala de Satisfação com a vida e a Escala de Afetos Positivos e Negativos). Resultados: Constatamos que, os idosos não institucionalizados apresentam níveis de BES mais elevados face aos idosos institucionalizados (p=0,023), com maior significância estatística na dimensão afetiva. Em relação aos determinantes do BES objetivou-se que, são os idosos “mais jovens” (p=0,015), do género masculino (p=0,000), com nível de escolaridade mais elevado (p=0,032), inseridos em famílias funcionais (p=0,010), que percecionam melhor estado de saúde (p=0,000) e que são mais autónomos na realização das suas ABVD’s (p=0,000) a apresentar níveis de bem-estar subjetivo mais elevado. Conclusão: As evidências encontradas neste estudo revelaram a existência de fatores determinantes na perceção do BES pela pessoa idosa daí a importância de planeamento e implementação de projetos direcionados à manutenção da autonomia, à diminuição das limitações, à maximização de potencialidades individuais, à promoção de relações interpessoais. Neste sentido, atendendo às competências do enfermeiro especialista de enfermagem de reabilitação, seria de extrema importância a incorporação deste profissional especializado nas Instituições e em equipas multidisciplinares de apoio a idosos na Comunidade. Palavras-chave: idoso, Bem – Estar Subjetivo, satisfação com a vida, afetos, determinantes.