The I, II, III. Philipics of Demosthenes, with historical introductions and critical and explanatory notes.

Mode of access: Internet.

The I. II. III. Philippics of Demosthenes, with historical introductions and critical explanatory notes.

Mode of access: Internet.

Indøvelse i christendom : Nr. I. II. III. /

Himmelstrup, J. Søren Kierkegaard,

Superior outcome of women with stage I/II cutaneous melanoma: pooled analysis of four European Organisation for Research and Treatment of Cancer phase III trials.

PURPOSE: Several studies observed a female advantage in the prognosis of cutaneous melanoma, for which behavioral factors or an underlying biologic mechanism might be responsible. Using complete and reliable follow-up data from four phase III trials of the European Organisation for Research and Treatment of Cancer (EORTC) Melanoma Group, we explored the female advantage across multiple end points and in relation to other important prognostic indicators. PATIENTS AND METHODS: Patients diagnosed with localized melanoma were included in EORTC adjuvant treatment trials 18832, 18871, 18952, and 18961 and randomly assigned during the period of 1984 to 2005. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% CIs for women compared with men, adjusted for age, Breslow thickness, body site, ulceration, performed lymph node dissection, and treatment. RESULTS: A total of 2,672 patients with stage I/II melanoma were included. Women had a highly consistent and independent advantage in overall survival (adjusted HR, 0.70; 95% CI, 0.59 to 0.83), disease-specific survival (adjusted HR, 0.74; 95% CI, 0.62 to 0.88), time to lymph node metastasis (adjusted HR, 0.70; 95% CI, 0.51 to 0.96), and time to distant metastasis (adjusted HR, 0.69; 95% CI, 0.59 to 0.81). Subgroup analysis showed that the female advantage was consistent across all prognostic subgroups (with the possible exception of head and neck melanomas) and in pre- and postmenopausal age groups. CONCLUSION: Women have a consistent and independent relative advantage in all aspects of the progression of localized melanoma of approximately 30%, most likely caused by an underlying biologic sex difference.

Biomasa y distribución del krill (euphausia superba) en el estrecho de Bransfield durante las operaciones Perú Antar I, II y III.

Describe las operaciones Perú Antar I, II y III que se ejecutaron entre los meses de enero y febrero de 1988, 1989 y 1991, respectivamente, a bordo del BIC Humboldt en el estrecho de Bransfield, ampliandose el área de estudio, en Antar III, a los alrededores de la isla Elefante. Se presenta la distribución horizontal y vertical así como los estimados de biomasa del krill (Euphausia superba) determinados en el área de estudio en tales expediciones. En todos los casos se emplearon los mismos equipos y similares metodologías. Se incluye una revisión de los antecedentes de evaluación acústica del krill tendientes al cálculo de su biomasa en la zona del Estrecho de Bransfield e Isla Elefante. Los estimados de biomasa fueron los siguientes: ANTAR I, 17.0x106 t (±29,41%) con una densidad de 536,05 g/m2; en ANTAR II, 5,67 x 106 t (±16,66%) con una densidad de 176,66 g/m2 ; en ANTAR III, 8,43 x 106 t (±12,0%) con una densidad de 200,93 g/m2 . Las principales zonas de concentración del krill se observaron entre la Isla Rey Jorge e Isla Elefante en ANTAR I; entre las Islas Bravante y Livingstone en ANTAR II; y, entre las Islas Decepción y Trinidad, y al norte de la Isla Elefante, en ANTAR III.

DNA Topoisomerase I Gene Copy Number and mRNA Expression Assessed as Predictive Biomarkers for Adjuvant Irinotecan in Stage II/III Colon Cancer.

PURPOSE: Prospective-retrospective assessment of theTOP1gene copy number andTOP1mRNA expression as predictive biomarkers for adjuvant irinotecan in stage II/III colon cancer. EXPERIMENTAL DESIGN: Formalin-fixed, paraffin-embedded tissue microarrays were obtained from an adjuvant colon cancer trial (PETACC3) where patients were randomized to 5-fluorouracil/folinic acid with or without additional irinotecan.TOP1copy number status was analyzed by fluorescencein situhybridization (FISH) using aTOP1/CEN20 dual-probe combination.TOP1mRNA data were available from previous analyses. RESULTS: TOP1FISH and follow-up data were obtained from 534 patients.TOP1gain was identified in 27% using a single-probe enumeration strategy (≥4TOP1signals per cell) and in 31% when defined by aTOP1/CEN20 ratio ≥ 1.5. The effect of additional irinotecan was not dependent onTOP1FISH status.TOP1mRNA data were available from 580 patients with stage III disease. Benefit of irinotecan was restricted to patients characterized byTOP1mRNA expression ≥ third quartile (RFS: HRadjusted, 0.59;P= 0.09; OS: HRadjusted, 0.44;P= 0.03). The treatment byTOP1mRNA interaction was not statistically significant, but in exploratory multivariable fractional polynomial interaction analysis, increasingTOP1mRNA values appeared to be associated with increasing benefit of irinotecan. CONCLUSIONS: In contrast to theTOP1copy number, a trend was demonstrated for a predictive property ofTOP1mRNA expression. On the basis ofTOP1mRNA, it might be possible to identify a subgroup of patients where an irinotecan doublet is a clinically relevant option in the adjuvant setting of colon cancer.Clin Cancer Res; 22(7); 1621-31. ©2015 AACR.

Reseña de 'Actas del I, II y III Congreso Internacional sobre Indigenismo americano'

Estos tres volúmenes de Actas de las sucesivas Jornadas Internacionales sobre Indigenismo Americano ponen al alcance dels lector un excepcional conjunto de trabajos de especialistas de ambas orillas del Atlántico.

Hispanoamérica atenta a la reforma educativa española : II Reunión del Consejo Directivo de la O.E.I. y III Conferencia Iberoamericana de Ministros de Educación, presidida por el prof. Villar Palasí.

Crónica de los hechos acontecidos durante la Segunda Reunión del Consejo Directivo de la Oficina de Educación Iberoamericana y la celebración de la Tercera Conferencia Iberoamericana de Ministros de Educación, en la que participaron los Ministros de Educación y Subsecretarios de varias naciones hispanoparlantes, así como otras personalidades e instituciones mundiales vinculadas al mundo de la Educación y Cultura en habla hispana. Se sucedieron entre el día 6 y 12 de octubre de 1970 en las ciudades de Toledo y Barcelona. Entre los temas que se trataron, destacaron: los problemas del idioma español en el mundo, la reforma de los estatutos de la Organización y la incorporación de nuevos Estados miembros, el desarrollo de la educación en los Estados representados, su situación actual y perspectivas a corto y a largo plazo, planteándose también una acción conjunta en el campo internacional y la equivalencia de estudios.

Expressão do PCNA e p53 em leucoplasias de mucosa jugal com diferentes graus de queratinização (Graus I, II, e III de Grinspan)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Concepções de educação ambiental e suas abordagens políticas: análise de trabalhos dos Encontros de Pesquisa em Educação Ambiental (I, II e III EPEAs)

Este artigo analisa os trabalhos apresentados nos I, II e III Encontrosde Pesquisa em Educação Ambiental (EPEAs). Tem como corpusdocumental 61 trabalhos, definidos através de uma amostragem aleatóriaestratificada a partir das edições dos eventos. Seus objetivos são: ainvestigação do entendimento dado à dimensão política da educaçãoambiental, a caracterização das concepções de educação ambiental e aidentificação das abordagens políticas dessas concepções. Trata-se de umaanálise documental de abordagem qualitativa. A análise foi realizadaatravés das categorias: concepção emancipatória de educação, concepçãotransformadora da relação sociedade-natureza (que configuram umaconcepção transformadora de EA), concepção conservadora de educaçãoe concepção conservadora da relação sociedade-natureza (que definemuma concepção conservadora de EA). Sessenta e quatro por cento dostrabalhos foram compreendidos como concepção transformadora e os36% restantes foram considerados portadores de uma concepçãoconservadora. Dos 61 trabalhos, 18 relacionam educação ambiental com adimensão política.