An overview of the current status of research into adopting high levels of renewables in Ireland

This paper provides an overview of the reduction targets that Ireland has set in the context of decarbonising their electricity generation through the use of renewables. The main challenges associated with integrating high levels (>20% of installed capacity) of non-dispatchable renewable generation are identified. The rising complexity of the challenge as renewable penetration levels increase is highlighted. A list of relevant research questions is then proposed, and an overview is given into the previous work that has gone into answering some of them. In particular, studies into the Irish energy market are identified, the current knowledge gap is described, and areas of necessary future research are suggested

Effects of butyrate on the colon cancer cell phenotype-chemosensitization and upregulation of proteins implicated in cancer progression

Colon cancer is the second leading cause of cancer mortality in the U.S. Surgery is the only truly effective human colon cancer (HCC) therapy due to marked intrinsic drug resistance. The inefficacy of therapies developed for metastatic HCC suggests that advances in colon cancer chemoprevention and chemotherapy will be needed to reduce HCC mortality. The dietary fiber metabolite butyrate (NaB) is a candidate cancer chemopreventive agent that inhibits growth, promotes differentiation and stimulates apoptosis of HCC cells. Epidemiological and experimental studies suggest that dietary fiber protects against the development of HCC, however, recent large prospective trials have not found significant protection. ^ The first central hypothesis of this dissertation project is that the diversity of phenotypic changes induced by NaB in HCC cells includes molecular alterations that oppose its chemopreventive action and thereby limit its efficacy. We investigated the effect of NaB on the expression/activity of epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) in HCC HT29 cells. NaB treatment induced a 13-fold increase in EGFR expression in concert with its chemopreventive action in vitro, i.e., induction of growth suppression and G1 arrest, apoptosis and a differentiated phenotype. NaB-induced EGFR was active based on multiple lines of evidence. The EGFR was: (1) heavily phosphorylated at Tyrosine (P-Tyr); (2) associated with the cytoskeleton; (3) localized at the cell surface, and activated in response to EGF; and (4) NaB treatment of the cells induced activation of the EGFR effector Erk1/2. NaB treatment also induced a 7-fold increase in COX-2 expression. The NaB-induced COX-2 was active based on significantly increased PGE2 production. ^ The second central hypothesis is that NaB treatment would render HCC cells more chemosensitive to chemotherapy agents based on the increased apoptotic index induced by NaB. NaB treatment chemosensitized HT29 cells to 5-FU and doxorubicin, despite increases in the expression of P-glycoprotein and a related drug resistance protein (MRP). ^ These results raise the intriguing possibility that the chemopreventive effects of fiber may require concomitant treatment with EGFR and/or COX-2 inhibitors. Similarly, NaB may be a rational drug to combine with existing chemotherapeutic agents for the management of advanced HCC patients. ^

Francisco de Miranda: forerunner of Spanish-American independence.

Includes bibliography.

Seasonality in Washington state employment,

Mode of access: Internet.

The phenomenology of minority-majority status:effects on innovation in argument generation

In three experiments, we manipulated participants' perceived numerical status and compared the originality and creativity of arguments generated by members of numerical minorities and majorities. Independent judges, blind to experimental conditions, rated participants' written arguments. In Studies 1 and 2, we found that participants assigned to a numerical minority generated more original arguments when advocating their own position than did numerical majorities. In Study 3, an equal-factions control group was included in the design, and all participants were instructed to argue for a counter-attitudinal position. Those in the numerical minority generated more creative arguments than those in both the majority and equal-factions conditions, but not stronger arguments. We propose cognitive and social processes that may underlie our obtained effects and discuss implications for minority influence research.

John Philip Sousa, Brustbild

Signatur des Originals: S 36/F06635

The miscellaneous works of the Rev. Matthew Henry : containing in addition to those heretofore published, numerous sermons now first printed from the original mss. : an appendix on what Christ is made to believers,in forty real benefits,by Philip Henry... : funeral sermons for Mr. and Mrs. Henry, by the Rev. Matthew Henry : funeral sermons on Mr. Matthew Henry, by W. Tong, John Reynolds, and Dr. Williams.

Includes the author's Life of the Rev. Philip Henry: p. [xii]-163.

An account of the plants Halesia and Gardenia in a letter from John Ellis ... to Philip Carteret Webb ...

Detached from: Philosophical transactions of the Royal Society of London. 1760. 51: 929-935, pl. 22-23.

Analogues of Chaucer's Canterbury pilgrimage (April 1386) and his putting-up joust-scaffolds, etc., in West-Smithfield (May 1390) being the expenses of the Aragonese ambassadors for 58 days in England, 21 July to 16 Sept. 1415, including their 4-days' journey from London to Canterbury and back, 31 July-3 Aug. 1415, and the cost of erecting scaffolds, etc., in West-Smithfield for the joust between Don Philip Boyl, knight, of Aragon, and John Asteley, esq., on Jan. 30, 1442, with Henry VI.'s allowances of materials for the said joust.

Mode of access: Internet.

Thirty thousand miles in "The Wanderer" : extracts from the log kept at various times by John Boit and Sam P. Blagden, Jr /

Mode of access: Internet.