Addresses and Messages to the General Court, Proclamations, Official Addresses and Statements.

Mode of access: Internet.

The charters and general laws of the Colony and Province of Massachusetts Bay,

Mode of access: Internet.

Acts and Resolves Passed by the General Court

Mode of access: Internet.

Clinical activity of ipilimumab for metastatic uveal melanoma: a retrospective review of the Dana-Farber Cancer Institute, Massachusetts General Hospital, Memorial Sloan-Kettering Cancer Center, and University Hospital of Lausanne experience.

BACKGROUND: Uveal melanoma exhibits a high incidence of metastases; and, to date, there is no systemic therapy that clearly improves outcomes. The anticytotoxic T-lymphocyte-associated protein 4 (anti-CTLA-4) antibody ipilimumab is a standard of care for metastatic melanoma; however, the clinical activity of CTLA-4 inhibition in patients with metastatic uveal melanoma is poorly defined. METHODS: To assess ipilimumab in this setting, the authors performed a multicenter, retrospective analysis of 4 hospitals in the United States and Europe. Clinical characteristics, toxicities, and radiographic disease burden, as determined by central, blinded radiology review, were evaluated. RESULTS: Thirty-nine patients with uveal melanoma were identified, including 34 patients who received 3 mg/kg ipilimumab and 5 who received 10 mg/kg ipilimumab. Immune-related response criteria and modified World Health Organization criteria were used to assess the response rate (RR) and the combined response plus stable disease (SD) rate after 12 weeks, after 23 weeks, and overall (median follow-up, 50.4 weeks [12.6 months]). At week 12, the RR was 2.6%, and the response plus SD rate was 46.%; at week 23, the RR was 2.6%, and the response plus SD rate was 28.2%. There was 1 complete response and 1 late partial response (at 100 weeks after initial SD) for an immune-related RR of 5.1%. Immune-related adverse events were observed in 28 patients (71.8%) and included 7 (17.9%) grade 3 and 4 events. Immune-related adverse events were more frequent in patients who received 10 mg/kg ipilimumab than in those who received 3 mg/kg ipilimumab. The median overall survival from the first dose of ipilimumab was 9.6 months (95% confidence interval, 6.3-13.4 months; range, 1.6-41.6 months). Performance status, lactate dehydrogenase level, and an absolute lymphocyte count ≥ 1000 cells/μL at week 7 were associated significantly with survival. CONCLUSIONS: In this multicenter, retrospective analysis of 4 hospitals in the United States and Europe of patients with uveal melanoma, durable responses to ipilimumab and manageable toxicity were observed.

Petition of Sever and Welsteed to the General Court (manuscript copy), [1723 June-August]

Two folio-sized leaves containing a two-page handwritten copy of the June 21, 1723 petition of Sever and Welsteed requesting the question of non-resident Fellows in the Corporation be readdressed by the General Court, and a one-page handwritten copy of the answer to the petition passed by the General Court on August 7, 1723. The text of the petition begins "Sheweth that we have formerly represented to the Overseers of the College the Difficulty we were under in the business of it by reason of our not being vested with the power of its Charter..." The petition is incorrectly dated as "June 24th 1722" instead of 1723.

Petition to the General Court (photostat copy), 1646 May 15

Photostat copy of a petition from ferrymen James Heyden and Francis Hudson requesting compensation for unpaid fares of "magistrates & deputyes" using the ferry.

Petition to the General Court (photostat copy), 1662

Photostat copy of a petition from ferrymen Francis Hudson and John Burrage requesting the General Court coin twopenny and fourpenny pieces for change so the ferrymen could accommodate customers attempting to pay with larger currency denominations.

Draft of a petition to the General Court from the Corporation, 1743 October 26-27

Two-page handwritten draft of a petition to the General Court signed by President Edward Holyoke, and a half-page letter that accompanied the draft from President Holyoke to Tutor Flynt, a member of the Committee to draft the petition.

The report of the committee about Harvard Coledge: presented to the Generall Court held the 3 of (3) month, 1654

Two folio-sized leaves with a handwritten draft of the May 3, 1654 report of a General Court Committee authorized to investigate the financial state of Harvard College. The report responds directly to eight questions raised in the September 10, 1653 Order of the General Court that established the Committee. The report provides summaries of Harvard's income sources and disbursements, offers recommendations regarding the President's salary and the allowances for the academic Fellows, steward, butler, and cook, and indicates specific contributions from local towns.

Report of the proceedings of the general court martial held at the King's Arms Tavern in Albany, April 4, 1776

Contains summaries of court-martials of a variety of soldiers for desertion, drunk and disorderly conduct, striking an officer, and damning the American congress.

Cases adjudged in the General Court of Virginia, 1733-1741

A copy of the reports by Edward Barradall of decisions of the general court of Virginia made by Gustavus A. Myers for William Green from a copy lent him by Conway Robinson.

The reform of the EU courts (II). Abandoning the management approach by doubling the General Court. Egmont Paper 83, March 2016

The 2011 proposal of the European Court of Justice aiming to increase the number of judges of the General Court has mutated after four years into a complete change of the EU judicial system. This long legislative debate was the first implementation of the Lisbon Treaty in the judicial domain. It has revealed different problems – formal and substantial – of the approach of public service reform in the European institutions.

Massachusetts General Hospital annual report.

Description based on: 1981; title from cover.

Problems of state life. A sermon delivered before His Excellency John D. Long, His Honor Byron Weston, the honorable Council, and the legislature of Massachusetts, at the annual election, King's chapel, Boston, Wednesday, January 3, 1883.

Printed by order of the Massachusetts General Court.