999 resultados para Martin, Saint


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"Extrait du Traité élémentaire d'histoire naturelle, par Martin Saint-Ange, Guérin, Thiébaut de Berneaud et Baudrimont."

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Mode of access: Internet.

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Diabetic nephropathy is characterized by excessive extracellular matrix accumulation resulting in renal scarring and end-stage renal disease. Previous studies have suggested that transglutaminase type 2, by formation of its protein crosslink product epsilon-(gamma-glutamyl)lysine, alters extracellular matrix homeostasis, causing basement membrane thickening and expansion of the mesangium and interstitium. To determine whether transglutaminase inhibition can slow the progression of chronic experimental diabetic nephropathy over an extended treatment period, the inhibitor NTU281 was given to uninephrectomized streptozotocin-induced diabetic rats for up to 8 months. Effective transglutaminase inhibition significantly reversed the increased serum creatinine and albuminuria in the diabetic rats. These improvements were accompanied by a fivefold decrease in glomerulosclerosis and a sixfold reduction in tubulointerstitial scarring. This was associated with reductions in collagen IV accumulation by 4 months, along with reductions in collagens I and III by 8 months. This inhibition also decreased the number of myofibroblasts, suggesting that tissue transglutaminase may play a role in myofibroblast transformation. Our study suggests that transglutaminase inhibition ameliorates the progression of experimental diabetic nephropathy and can be considered for clinical application.

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This report presents an overview of the land-based biodiversity of the St Martin's Island, based on field visits during October 2014 and from historical data.

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This report seeks to strengthen national capacity on managing Marine Protected Area (MPAs) in Bangladesh. St Martin's Island was used as the pilot ecosystem boundary delineation.

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Orné de cinq grandes peintures, obtenu par échange de la Bibliothèque royale de Copenhague.