914 resultados para Leonard, Clifford M.


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Compressed sensing is a new paradigm in signal processing which states that for certain matrices sparse representations can be obtained by a simple l1-minimization. In this thesis we explore this paradigm for higher-dimensional signal. In particular three cases are being studied: signals taking values in a bicomplex algebra, quaternionic signals, and complex signals which are representable by a nonlinear Fourier basis, a so-called Takenaka-Malmquist system.

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Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive chemotherapy. As medulloblastoma exhibits marked intertumoural heterogeneity, with at least four distinct molecular variants, previous attempts to identify targets for therapy have been underpowered because of small samples sizes. Here we report somatic copy number aberrations (SCNAs) in 1,087 unique medulloblastomas. SCNAs are common in medulloblastoma, and are predominantly subgroup-enriched. The most common region of focal copy number gain is a tandem duplication of SNCAIP, a gene associated with Parkinson's disease, which is exquisitely restricted to Group 4α. Recurrent translocations of PVT1, including PVT1-MYC and PVT1-NDRG1, that arise through chromothripsis are restricted to Group 3. Numerous targetable SCNAs, including recurrent events targeting TGF-β signalling in Group 3, and NF-κB signalling in Group 4, suggest future avenues for rational, targeted therapy.

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Indenture of bargain and sale between Orson Phelps formerly of St. Catharines, but at the time of the transaction, was living in Buffalo, New York and Calista M. Phelps (his wife) and Owen Clifford of Grantham for lots numbered 12 and 13 in the 8th Concession in Grantham Township. The instrument no. is 3411, July 11, 1851.

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Indenture of mortgage deed between Owen Clifford and Margaret Clifford of the Township of Grantham to Samuel D. Woodruff of St. Catharines regarding 36 3/4 acres in Lots numbered 12 and 13 in the 8th Concession in the Township of Grantham - instrument no. 187. This was registered at the Registry Office for Lincoln on April 30, 1867 in Liber I, March 29, 1867.

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Indenture of mortgage deed between Owen Clifford and Margaret Clifford of the Township of Grantham to John Charles Rykert and William B. Gilleland of St. Catharines regarding parts of Lots no. 10 and 11 in the 9th Concession of the Township of Grantham. Registered in the Township of Grantham Register on September 15, 1870 - instrument no. 804 and registered in the Township of Grantham Register of February 8, 1872 - instrument no. 1104, September 15, 1870.

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Indenture of deed of land between Margaret Clifford of Grantham and Samuel D. Woodruff of St. Catharines for lots 12 and 13 in the 8th Concession in the Township of Grantham. This was registered February 7, 1872 - instrument no. 19112 [?], February 2, 1872.

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Statement from the Sheriff’s Office, Lincoln that there are no writs of execution or extent against Owen Clifford. This is signed by Joseph A. Woodruff, March 5, 1869.