Neurodegenerative diseases in domestic animals: a comparative review

Neurodegenerative diseases are characterised by selective damage to specific neurons in the nervous system. Interest in such diseases in humans has resulted in considerable progress in the molecular understanding of these disorders in recent decades. Numerous neurodegenerative diseases have also been described in domestic animals but relatively little molecular work has been reported. In the present review, we have classified neurodegenerative disease according to neuroanatomical criteria. We have established two large groups, based on whether the neuronal cell body or its axon was primarily affected. Conditions such as motor neuron diseases, cerebellar degenerations and neuroaxonal dystrophies are discussed in terms of their clinical and neuropathological features. In the most studied disorders, we also present what is known about underlying pathomechanisms, and compare them with their human counterparts. The purpose of this review is to re-kindle interest in this group of diseases and to encourage veterinary researchers to investigate molecular mechanisms by taking advantage of current diagnostic tools.

Occurrence and geochemistry of lake-bottom manganiferous deposits in Canadian lakes

It is the purpose of this paper to record information concerning the distribution and occurrence of manganiferous concretions and other manganese oxide deposits that develop on certain lake bottoms. During the summer of 1935 several days were devoted to a study of this type of lake bottom deposit in various parts of Nova Scotia. Lake studies in Ontario have extended the known distribution from lakes on or near the Atlantic coast to lakes in southern Ontario. During the writer's first work on lacustrine manganiferous deposits the concretions of manganese oxide which were found were almost entirely limited to the relatively shallow parts of the lakes examined. Other lakes are now known where the manganese oxide appears to occur only in the maximum depths.

Imaginario social en la publicidad web de los e-readers

Se exploran las significaciones imaginarias que se materializan en los discursos publicitarios sobre los aparatos lectores de libros electrónicos comúnmente denominados "e-readers". Se parte de la hipótesis de que se cruzan significaciones imaginarias asociadas tanto al imaginario neotecnológico de las tecnologías digitales (Cabrera, 2006, 2011) como a lo que podríamos denominar el imaginario del "orden de los libros" (Chartier, 2000, 2005). Para realizar la exploración se analizan los discursos publicitarios de las páginas Web de tres casos: las marcas Kindle de Amazon, Kobo y Bq de Movistar. Se concluye que los e-readers son aparatos que participan del imaginario neotecnológico y vienen a integrar el complejo de las tecnologías digitales para la vida cotidiana, y que remiten también en gran medida a las significaciones imaginarias que dieron lugar a la hegemonía del papel en la cultura occidental por más de cinco siglos.

Imaginario social en la publicidad web de los e-readers

Se exploran las significaciones imaginarias que se materializan en los discursos publicitarios sobre los aparatos lectores de libros electrónicos comúnmente denominados "e-readers". Se parte de la hipótesis de que se cruzan significaciones imaginarias asociadas tanto al imaginario neotecnológico de las tecnologías digitales (Cabrera, 2006, 2011) como a lo que podríamos denominar el imaginario del "orden de los libros" (Chartier, 2000, 2005). Para realizar la exploración se analizan los discursos publicitarios de las páginas Web de tres casos: las marcas Kindle de Amazon, Kobo y Bq de Movistar. Se concluye que los e-readers son aparatos que participan del imaginario neotecnológico y vienen a integrar el complejo de las tecnologías digitales para la vida cotidiana, y que remiten también en gran medida a las significaciones imaginarias que dieron lugar a la hegemonía del papel en la cultura occidental por más de cinco siglos.

Imaginario social en la publicidad web de los e-readers

Se exploran las significaciones imaginarias que se materializan en los discursos publicitarios sobre los aparatos lectores de libros electrónicos comúnmente denominados "e-readers". Se parte de la hipótesis de que se cruzan significaciones imaginarias asociadas tanto al imaginario neotecnológico de las tecnologías digitales (Cabrera, 2006, 2011) como a lo que podríamos denominar el imaginario del "orden de los libros" (Chartier, 2000, 2005). Para realizar la exploración se analizan los discursos publicitarios de las páginas Web de tres casos: las marcas Kindle de Amazon, Kobo y Bq de Movistar. Se concluye que los e-readers son aparatos que participan del imaginario neotecnológico y vienen a integrar el complejo de las tecnologías digitales para la vida cotidiana, y que remiten también en gran medida a las significaciones imaginarias que dieron lugar a la hegemonía del papel en la cultura occidental por más de cinco siglos.

Imaginario social en la publicidad web de los e-readers

Se exploran las significaciones imaginarias que se materializan en los discursos publicitarios sobre los aparatos lectores de libros electrónicos comúnmente denominados "e-readers". Se parte de la hipótesis de que se cruzan significaciones imaginarias asociadas tanto al imaginario neotecnológico de las tecnologías digitales (Cabrera, 2006, 2011) como a lo que podríamos denominar el imaginario del "orden de los libros" (Chartier, 2000, 2005). Para realizar la exploración se analizan los discursos publicitarios de las páginas Web de tres casos: las marcas Kindle de Amazon, Kobo y Bq de Movistar. Se concluye que los e-readers son aparatos que participan del imaginario neotecnológico y vienen a integrar el complejo de las tecnologías digitales para la vida cotidiana, y que remiten también en gran medida a las significaciones imaginarias que dieron lugar a la hegemonía del papel en la cultura occidental por más de cinco siglos.

(Table, page 500) Geochemistry of a pancake-shaped concretion from lake Charlotte, Canada

A pancake-shaped concretion from Ship Harbour Lake, a small freshwater lake in eastern Nova Scotia (now named Lake Charlotte) is part of collection sent to the National Museum of Canada by Mr. R. A. Logan, of the Pan American Airvays. These concretions are of similar to the well-known marine concretions with a composition similar to wad. These are known only from abyssmal depths of the sea in the red clay deposits, while the present concretions occur in very shallow lake waters. They should be of interest to geologists, who may be concerned with the rather difficult problem which some concretions raise of distinguishing between concretions of syngenitic and epigenetic origin.

The Chloroplast atpA Gene Cluster in Chlamydomonas reinhardtii1 : Functional Analysis of a Polycistronic Transcription Unit

Most chloroplast genes in vascular plants are organized into polycistronic transcription units, which generate a complex pattern of mono-, di-, and polycistronic transcripts. In contrast, most Chlamydomonas reinhardtii chloroplast transcripts characterized to date have been monocistronic. This paper describes the atpA gene cluster in the C. reinhardtii chloroplast genome, which includes the atpA, psbI, cemA, and atpH genes, encoding the α-subunit of the coupling-factor-1 (CF1) ATP synthase, a small photosystem II polypeptide, a chloroplast envelope membrane protein, and subunit III of the CF0 ATP synthase, respectively. We show that promoters precede the atpA, psbI, and atpH genes, but not the cemA gene, and that cemA mRNA is present only as part of di-, tri-, or tetracistronic transcripts. Deletions introduced into the gene cluster reveal, first, that CF1-α can be translated from di- or polycistronic transcripts, and, second, that substantial reductions in mRNA quantity have minimal effects on protein synthesis rates. We suggest that posttranscriptional mRNA processing is common in C. reinhardtii chloroplasts, permitting the expression of multiple genes from a single promoter.

Transit Peptide Mutations That Impair in Vitro and in Vivo Chloroplast Protein Import Do Not Affect Accumulation of the γ-Subunit of Chloroplast ATPase1

We have begun to take a genetic approach to study chloroplast protein import in Chlamydomonas reinhardtii by creating deletions in the transit peptide of the γ-subunit of chloroplast ATPase-coupling factor 1 (CF1-γ, encoded by AtpC) and testing their effects in vivo by transforming the altered genes into an atpC mutant, and in vitro by importing mutant precursors into isolated C. reinhardtii chloroplasts. Deletions that removed 20 or 23 amino acid residues from the center of the transit peptide reduced in vitro import to an undetectable level but did not affect CF1-γ accumulation in vivo. The CF1-γ transit peptide does have an in vivo stroma-targeting function, since chimeric genes in which the stroma-targeting domain of the plastocyanin transit peptide was replaced by the AtpC transit peptide-coding region allowed plastocyanin to accumulate in vivo. To determine whether the transit peptide deletions were impaired in in vivo stroma targeting, mutant and wild-type AtpC transit peptide-coding regions were fused to the bacterial ble gene, which confers bleomycin resistance. Although 25% of the wild-type fusion protein was associated with chloroplasts, proteins with transit peptide deletions remained almost entirely cytosolic. These results suggest that even severely impaired in vivo chloroplast protein import probably does not limit the accumulation of CF1-γ.

The Kharkiv oblast: a fragile stability. OSW COMMENTARY NUMBER 172/03.06.2015

Kharkiv oblast, which is located in the immediate vicinity of the Donbas region, and which shares a 315-km stretch of Ukraine’s border with Russia, was one of the regions where attempts were made to kindle separatist sentiments during the spring of last year. Some central government buildings were briefly occupied by pro-Russian demonstrators who declared a ‘Kharkov People’s Republic’, but efficient countermeasures by the Ukrainian institutions of force quickly calmed the situation in the region. However, the oblast still remains a target for acts of sabotage, which are probably directed by Russian secret services. Nevertheless, the situation in the region is now stable, both in terms of public sentiment and local politics. The main competitors in the arena of local politics are Hennadiy Kernes, the mayor of Kharkiv, and Arsen Avakov, the current head of the Ukrainian Interior Ministry. Despite many years of hostility, neither of the politicians appears to have initiated a power struggle as yet – Kernes retains his influence on the city council, and Avakov controls the local security services.

El Periodismo de Datos en España

El Periodismo de Datos se ha convertido en una de las tendencias que se están implantando en los medios. En pocos años el desarrollo y visibilidad de esta modalidad ha aumentado considerablemente y son numerosos los medios que cuentan con equipos y espacios específicos de Periodismo de Datos en el panorama internacional. Del mismo modo, existen aplicaciones, plataformas, webs, o fundaciones al margen de las empresas periodísticas cuya labor también puede ser enmarcada en este ámbito. El objetivo principal de esta contribución es establecer una radiografía de la implantación del Periodismo de Datos en España; tanto dentro como fuera de los medios. Aunque se trata de una disciplina todavía en fase de desarrollo, parece adecuado realizar un estudio exploratorio que ofrezca una panorámica de su situación actual en España.

El concepto de ciudadanía en la obra de Dominique Schnapper: entre el tipo ideal sociológico y el ideal de sociedad democrática

Este artículo analiza la evolución del concepto de ciudadanía en la obra de Dominique Schnapper como uno de los ejemplos más destacados en la sociología contemporánea de una aproximación completa a la cuestión. A través de un recorrido exhaustivo por su obra, el objetivo es profundizar en la comprensión de la tensión entre la dinámica democrática y la idea de ciudadanía en cuanto que tipo ideal del vínculo social y como principio regulador de las sociedades democráticas. La autora propone en sus primeros trabajos una noción de ciudadanía vinculada al proceso político de construcción de la nación que no distingue entre la definición de un tipo ideal sociológico y la construcción de un ideal de sociedad. Esta confusión se corrige al introducir posteriormente en el análisis la incidencia de la democracia sobre las experiencias individuales de la ciudadanía, aportando una perspectiva de análisis de gran utilidad tanto para la comprensión de la dinámica contemporánea de las sociedades democráticas como para la necesaria defensa de la ciudadanía como vínculo social fundamental y como principio fundador de la legitimidad política.

David Hume and contractualism

David Hume belonged to the consecuencialist philosophical tendency, in which is included utilitarianism. This tendency was opposed to the normativism philosophy, in which is enrolled contractualism. This article analyzes the critique made by David Hume, from the utilitarianism perspective, against contractualism. The major philosophers of contractualism are Thomas Hobbes, John Locke and Jean Jacques Rousseau. Hume implemented three arguments in opposition to them: 1) historic: the social contract does not have any practical testing. Therefore it could not be presented as the foundation of the state; 2) philosophical: it is not the duty, but the interest that moves men to seek the formation of the political authority; 3) social: in the consciousness of the people, there is no trace of the social contract.Utilitarianism was one of the philosophical tendencies that finished the theoretical hegemony that contractualism had during the XVII and the XVIII centuries. Nonetheless from the historical and social point of view, the liberalization movements in many parts of the world, at that time, were inspired by contractualism. It means that from the theoretical point of view, utilitarianism, certainly, stressed the empirical origins of the state but not the rational justification of the political Authority. Hume was unable to understand the normative force that contractualism owns, which inspires human action.