Maternal separation followed by isolation-housing differentially affects prepulse inhibition of the acoustic startle response in C57BL/6 mice

Exposure to chronic stress is associated with an increased incidence of neuropsychiatric dysfunction. The current study evaluated two competing hypotheses, the cumulative stress and the match/mismatch hypothesis of neuropsychiatric dysfunction, using two paradigms relating to exposure to “stress”: pre-weaning maternal separation and post-weaning isolation-housing. C57BL/6 offspring were reared under four conditions: typical animal facility rearing (AFR, control), early handling (EH, daily 15 min separation from dam), maternal separation (MS, daily 4 hr separation from dam), and maternal and peer separation (MPS, daily 4 hr separation from dam and from littermates). After weaning, mice were either housed socially (2–3/cage) or in isolation (1/cage) and then tested for prepulse inhibition in adulthood. Isolation-housed MPS subjects displayed greater deficits in prepulse inhibition relative to socially-housed MPS subjects while socially-housed AFR subjects displayed greater deficits in prepulse inhibition relative to isolation-housed AFR subjects. The results indicate that these treatment conditions represent a potentially valuable model for evaluating the match/mismatch hypothesis in regards to neuropsychiatric dysfunction.

Refrigeration and air conditioning

Includes bibliographies.

The works and life of Walter Bagehot,

"Second memoir, by Richard Holt Hutton (from Dict. of nat. biog.)": v. 1, p. 47-64.

An abridgment of Ainsworth's dictionary, English and Latin, designed for the use of schools.

Mode of access: Internet.

Essai sur la vie, les écrits et les opinions de m. de Malesherbes,

Mode of access: Internet.

Discours et opinions de Rabaut-Saint-Étienne, suivis de ses deux derniers écrits, et précedés d'une notice sur sa vie par M. le Cte de Boissy-d'Anglais.

Mode of access: Internet.

Literary essays.

Goethe and his influence -- The genius of Wordsworth -- Shelley and his poetry -- Mr. Browning -- The poetry of the Old Testament -- Arthur Hugh Clough -- The poetry of Matthew Arnold -- Tennyson -- Nathaniel Hawthorne.

The Quarterly review.

Editors: 1809-24, William Gifford.--1824-26, J.T. Coleridge.--1826-53, J.G. Lockhart.--1853-60, Whitwell Elwin.--1860-67, William Macpherson.--1867-93, William Smith.--1894, John Murray, 1894-99, R.E. Prothero.--1899- G.W. Prothero.

P. Papinii Statii Opera /

Edited by J. Carey--Cf. BLC, v. 311, p. 464.

An abridgment of Ainsworth's dictionary. English and Latin, designed for the use of schools.

Mode of access: Internet.

Sir Walter Scott,

Abridged from Lockhart's "Life of Walter Scott," published in 10 volumes, Edinburgh, 1839. cf. Prefatory notes.

Plays /

v. 1. Advertisement to the second edition. Introduction; Essay on the writings of Massinger / by John Ferriar, &c. The virgin-martyr. The unnatural combat. The Duke of Milan -- v. 2. The bondman. The renegado. The parilament of love. The Roman actor. The great Duke of Florence -- v. 3. The maid of honour. The picture. The Emperor of the East. The fatal dowry. A new way to pay old debts -- v. 4. The city madam. The guardian. A very woman. The bashful lover. The old law.