A new short and simple health-related quality of life measurement for paediatric rheumatic diseases: initial validation in juvenile idiopathic arthritis

Objective. To develop and validate a new short and simple measure of health-related quality of life (HRQL) in children with juvenile idiopathic arthritis (JIA).Methods. The Paediatric Rheumatology Quality of Life Scale (PRQL) is a 10-item questionnaire that explores HRQL in two domains: physical health (PhH) and psychosocial health (PsH). Validation of the parent proxy report and child self-report versions of the instrument was accomplished by evaluating 472 JIA patients and similar to 800 healthy children. Validation analyses included assessment of feasibility, face and content validity; construct and discriminative ability; internal structure and consistency; test-retest reliability; responsiveness to clinical change; and minimal clinically important difference.Results. The PRQL was found to be feasible and to possess both face and content validity. The PRQL score correlated in the predicted range with most of the other JIA outcome measures, thereby demonstrating good construct validity, and discriminated well between different levels of disease severity. Assessment of internal structure (factor analysis) revealed that the PhH and PsH subscales identify two unambiguously separated domains. The internal consistency (Cronbach's alpha) was 0.86. The intraclass correlation coefficient for test-retest reliability was 0.91. The PRQL revealed fair responsiveness, with a standardized response mean of 0.67 in improved patients. Overall, the PRQL appeared to be more able to capture physical HRQL than psychosocial HRQL.Conclusion. The PRQL was found to possess good measurement properties and is, therefore, a valid instrument for the assessment of HRQL in children with JIA. This tool is primarily proposed for use in standard clinical care.

Historical sketches and incidents, illustrative of the establishment and progress of Universalism in the State of New York.

Mode of access: Internet.

The history of the New-York African free-schools, from their establishment in 1787, to the present time; embracing a period of more than forty years:

Mode of access: Internet.

American naval battles; being a complete history of the battles fought by the Navy of the United States, from its establishment in 1794 to the present time; including the wars with France and Tripoli; the late war with Great Britain, and with Algiers; with an account of the attack on Baltimore, and of the battle of New Orleans ...

Published previously, Boston, 1816, by Barber Badger, under title: The naval temple.

American naval battles : being a complete history of the battles fought by the navy of the United States, from its establishment in 1794 to the present time : including the wars with France and Tripoli : the late war with Great Britain, and with Algiers : with an account of the attack on Baltimore, and of the battle of New Orleans.

Published previously, Boston, 1816, by Barber Badger, under title: The naval temple.

On the establishment of public schools, in the city of New-York.

Appendix, pp.[12]-18, contains the memorial, approved by the Commissioners of the Common School Fund and the Common Council of New York City, and the Legislature's "Act in relation to the Free School Society of New York."

Memorial of merchants, ship owners, and others, against the establishment by Congress, of additional lines of steamships under government contracts.

Signed by John Griswold and others.

Multifaceted roles of the lysosome in the establishment and expansion of tuberculous infection

Thesis (Ph.D.)--University of Washington, 2016-04

The role of microcomputer-based laboratory display in supporting the construction of new understanding in kinematics

Teachers' failure to utilise MBL activities more widely may be due to not recognising their capacity to transform the nature of laboratory activities to be more consistent with contemporary constructivist theories of learning. This research aimed to increase understanding of how MBL activities specifically designed to be consistent with a constructivist theory of learning support or constrain student construction of understanding. The first author conducted the research with his Year 11 physics class of 29 students. Dyads completed nine tasks relating to kinematics using a Predict-Observe-Explain format. Data sources included video and audio recordings of students and teacher during four 70-minute sessions, students' display graphs and written notes, semi-structured student interviews, and the teacher's journal. The study identifies the actors and describes the patterns of interactions in the MBL. Analysis of students' discourse and actions identified many instances where students' initial understanding of kinematics were mediated in multiple ways. Students invented numerous techniques for manipulating data in the service of their emerging understanding. The findings are presented as eight assertions. Recommendations are made for developing pedagogical strategies incorporating MBL activities which will likely catalyse student construction of understanding.