On the contribution of stereochemistry to human ITPK1 specificity: Ins(1,4,5,6)P4 is not a physiologic substrate

Ins(1,4,5,6)P4, a biologically active cell constituent, was recently advocated as a substrate of human Ins(3,4,5,6)P4 1-kinase (hITPK1), because stereochemical factors were believed relatively unimportant to specificity [Miller, G.J. Wilson, M.P. Majerus, P.W. and Hurley, J.H. (2005) Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-triphosphate 5/6-kinase. Mol. Cell. 18, 201-212]. Contrarily, we provide three examples of hITPK1 stereospecificity. hITPK1 phosphorylates only the 1-hydroxyl of both Ins(3,5,6)P3 and the meso-compound, Ins(4,5,6)P3. Moreover, hITPK1 has >13,000-fold preference for Ins(3,4,5,6)P4 over its enantiomer, Ins(1,4,5,6)P4. The biological significance of hITPK1 being stereospecific, and not physiologically phosphorylating Ins(1,4,5,6)P4, is reinforced by our demonstrating that Ins(1,4,5,6)P4 is phosphorylated (K(m) = 0.18 microM) by inositolphosphate-multikinase.

International Coordination in Cross-Border Bank Bail-ins: Problems and Prospects

Bail-in is quickly becoming a predominant approach to banking resolution. The EU Bank Recovery Resolution Directive and the US Federal Deposit Insurance Corporation’s single point of entry strategy envisage creditors’ recapitalisations
to resolve a failing financial institution. However, this legislation focuses on the domestic aspects of bail-in, leaving the question of how it is applied
to a cross-border banking group open. Cross-border banking resolution has been historically subject to coordination failures, which have resulted in disorderly resolutions with dangerous systemic effects. The goal of this article is to assess whether bail-in is subject to the same coordination problems that affect other resolution tools, and to discuss the logic of international legal cooperation in bail-in policies. We demonstrate that, in spite of the evident benefit in terms of fiscal sustainability, bail-in suffers from complex coordination problems which, if not addressed, might lead to regulatory arbitrage and lengthy court battles, and, ultimately, may disrupt resolutions. We argue that only a binding legal regime can address those problems. In doing so, we discuss the recent Financial Stability
Board’s proposal on cross-border recognition of resolution action, and the role of international law in promoting cooperation in banking resolution.

Wartung mit ins Logistik-Konzept!

Ausfall- und Ausfallfolgekosten sowie Wiederanlauf- und Zusatzlaufkosten zwingen auch nach betriebswirtschaftlichen Gesichtspunkten die Unternehmen, die Bedeutung und den Umfang der Instandhaltungsaktivitäten höher als bisher einzuschätzen. Der Artikel befasst sich mit der Fragen, warum die Wartung mit in das Logistik-Konzept aufgenommen werden soll.

Inês Pedrosa

Inês Pedrosa nasceu em Coimbra, em 15 de Agosto de 1962. Da sua professora primária, Virgínia Rodrigues, veio o amor pelos livros e do avô materno, Domingos Pereira, o grande incentivo literário: “contava-me a história de Portugal e declamava Camões, enquanto me passeava de barco a remos no rio Nabão. Ele é o avô Matias no meu primeiro romance A Instrução dos Amantes “ (JL, 2004: p.44). Em 1984, licencia-se em Ciências da Comunicação, na Universidade Nova de Lisboa; No Jornal de Letras, adquire pela prática o “curso de jornalismo, de literatura, de cultura, de vida” (JL, Agosto, 2002), convivendo com António Mega Ferreira, Augusto Abelaira, Eduardo Prado Coelho, Jorge Listopad e Fernando Assis Pacheco. Passaria depois pelo Independente, pelo Expresso, pela revista Ler e, finalmente, pela revista Marie Claire (entre 1993 e 1996), além de ter tido algumas experiências em rádio e televisão. Inês Pedrosa tem sido uma animadora constante de laços nacionais e internacionais, promovendo autores, através de col

Vozes Femininas em A Descoberta do Mundo, de Clarice Lispector, e Crónica Feminina, de Inês Pedrosa

Esta tese que confronta duas antologias cronísticas, A Descoberta do Mundo, de Clarice Lispector, e Crónica Feminina, de Inês Pedrosa, pretende evocar, através de seu discurso cronístico, as duas vozes femininas das obras. Embora inserida em contexto histórico e geocultural diferente, a leitura de suas crónicas permite a evocação de outras vozes que confluem neste universo cronístico de cada escritora, cujas ressonâncias buscaremos compreender nos Estudos sobre as Mulheres no Brasil e em Portugal, através da evolução do conceito de crónica nos dois países.

La narrativa de Inés Arredondo en La señal un acercamiento lingüístico-discursivo [por] Atala Hilda Vela Rubalcava

Tesis (Maestría en Letras Españolas) U.A.N.L.

Formación de CulnS² a partir de multicapas de In²S³-CuS como absorbedor en celdas solares.

Tesis (Maestría en Ciencias con Especialidad en Química de los Materiales) UANL, 2011

Originalidad e hibridación en Amor es más laberinto. Comedia escrita por Sor Juana Inés de la Cruz y Juan de Guevara en 1689.

Tesis (Maestría en Ciencias con Especialidad en Lengua y en Literatura) UANL, 2012.

Propuesta de ordenamiento comunitario participativo del ejido Santa Inés, Iturbide, Nuevo León.

Tesis (Maestría en Ciencias Sociales con orientación en Desarrollo Sustentable) UANL, 2013.