Abnormal expression of CD54 in mixed reactions of mononuclear cells from hyper-IgE syndrome patients

Hyper-IgE syndrome (HIES) is a rare multisystem disorder characterized by increased susceptibility to infections associated with heterogeneous immunologic and non-immunologic abnormalities. Most patients consistently exhibit defective antigen-induced-T cell activation, that could be partly due to altered costimulation involving accessory molecules; however, the expression of these molecules has never been documented in HIES. Therefore, we investigated the expression of CD11a, CD28, CD40, CD54, CD80, CD86, and CD154 in peripheral blood mononuclear cells from six patients and six healthy controls by flow cytometry after autologous and mixed allogeneic reactions. Only the allogeneic stimuli induced significant proliferative responses and interleukin 2 and interferon gamma production in both groups. Most accessory molecules showed similar expression between patients and controls with the exception of CD54, being expressed at lower levels in HIES patients regardless of the type of stimulus used. Decreased expression of CD54 could partly explain the deficient T cell activation to specific recall antigens in HIES patients, and might be responsible for their higher susceptibility to infections with defined types of microorganisms.

[Archives de la Parole]. , [Bapala durang] : [song in Hō] ; [Mage durang] : [song in Hō] / [Sir George Grierson], éd. ; Linguistic survey of India ; Choeur (femmes, ou enfants) ; accompagnement de percussions et de flûte

[Traditions. Asie. Inde. Chotā Nāgpur]

Sweet bird that shunn'st the noise of folly : [extr. de "L'Allegro, il penseroso ed il moderato"] / Haendel, comp. ; Mme Melba, S ; avec orchestre et flûte. O lovely night / Ronald, comp. ; Mme Melba, S ; avec orchestre

Comprend : Sweet bird that shunn'st the noise of folly / Haendel, comp. ; Mme Melba, S ; avec orchestre et flûte ; O lovely night / Ronald, comp. ; Mme Melba, S ; avec orchestre

[Archives de la Parole]. , Jhijit khambag (Bengali Song) / William Sinkler Darby, collecteur ; Abdool Gafoor [i.e. Ustad Abdul Gafur], chant ; accompagnement instrumental (harmonium indien, tablâ, flûte)

[Traditions. Asie. Inde]

La flûte et le tambour, ou Le bon tems revenu : dédié à la fédération générale, du 14 juillet 1790 ([Reprod.])

Collection : Les archives de la Révolution française ; 6.2.1130

Les antagonistes des récep- teurs de l'endothéline ont-ils une place dans le traitement de l'hyper- tension artérielle [Do endothelin receptors antagonists have a place in the treatment of arterial hypertension?].

The discovery in 1988 of endothelin, the most potent human endogenous vasoconstrictor, has opened the race to the discovery of a new weapon against arterial hypertension. The development of the endothelin receptors antagonists (ERAs) and the demonstration of their efficacy in preclinical models initially raised a wave of enthusiasm, which was however tempered due to their unfavorable side effect profile. In this article we will review the phases of the development ERAs, and their current and future place as therapeutic tool against arterial hypertension.

[Archives de la Parole]. , Hackani (Hindustani Song) / William Sinkler Darby, collecteur ; [Miss] Hingan Bai, chant ; accompagnement instrumental (harmonium indien, tabla et flûte)

[Traditions. Asie. Inde]

[Archives de la Parole]. , Gour sarang (Hindustani Song) [sic] / William Sinkler Darby, collecteur ; Neekunjo Bebary Dutt [i.e. Babu Nikunja Behari Dutt], chant ; accompagnement instrumental (tabla, flûte et harmonium indien)

[Traditions. Asie. Inde]

[Archives de la Parole]. , Jhijit khambag (Hindustani Song) / William Sinkler Darby, collecteur ; Dijendra Nath Bagchi [i.e. Babu Dejendra Nath Bagchi], chant ; accompagnement instrumental (tablâ, flûte et harmonium indien)

[Traditions. Asie. Inde]

[Archives de la Parole]. , Bhairobi (Hindustani Song) / William Sinkler Darby, collecteur ; Abdool Gafoor [i.e. Ustad Abdul Gafur], chant ; accompagnement instrumental (tabla, flûte et harmonium?)

[Traditions. Asie. Inde]

[Archives de la Parole]. , Bhairobi (Bengali Song) / William Sinkler Darby, collecteur ; Neekunjo Behary Dutt [i.e. Babu Nikunja Behari Dutt], chant ; accompagnement instrumental (harmonium indien, tablâ, flûte)

[Traditions. Asie. Inde]

[Archives de la Parole]. , Khambag (Bengali Song) / William Sinkler Darby, collecteur ; Harry Charan Addy [i.e. Babu Hari Charan Adya], chant ; accompagnement instrumental (harmonium indien, tablâ, flûte)

[Traditions. Asie. Inde]

[Archives de la Parole]. , Jhijit medley (Bengali Song) / William Sinkler Darby, collecteur ; Abdool Gafoor [i.e. Ustad Abdul Gafur], chant ; accompagnement instrumental (harmonium indien, tablâ, flûte)

[Traditions. Asie. Inde]