Rouva Nina Petrovna Hrushtsheva 14/9 1971

Kirje 14.9.1971

7/11 1960 Kunnioitettu Herra Ministerineuvoston Puheenjohtaja

Kirje 7.11.1960

Neiti Ester Willberg 4/11 1964

Kirje 4.11.1964

A pilot study on ocular safety and efficacy of infliximab as an antifibrotic agent after experimental filtration surgery

Purpose To evaluate the safety and efficacy of infliximab as an antifibrotic agent after experimental glaucoma filtration surgery in rabbits. Methods In a randomized, prospective, masked-observer study, 30 New Zealand Albino rabbits underwent glaucoma filtration surgery. The animals were allocated to receive either intraoperative application of infliximab (group A) or mitomycin C (MMC) at a concentration of 0.2mg/ml (group B) or balanced salt solution (BSS, control)(group C). Different infliximab doses, namely 1.0mg, 2.0mg, 3.0mg, 4.0mg, 5.0mg in 0.1ml were applied. Bleb survival and characteristics were evaluated over a 30day period. The animals were killed on postoperative day 15 and 30. Histology of the operated eyes was performed to evaluate and grade the amount of scarring in each group.Cellular density was evaluated in each case. Results Infliximab did not appear to improve the outcome of filtration surgery in this model of glaucoma filtration surgery.There was a significant decrease in cellular density in the MMC group compared to the control group (p=0.0352). There was neither a significant decrease in cellular density between the infliximab group and the control group nor between the infliximab group and the MMC group. Overall there was no difference in terms of fibrosis between the three different groups. There was slightly less inflammation in the infliximab group, but not significant. Conclusions In this study intraoperative application of infliximab does not appear to be superior to the application of MMC or a control with regard to bleb survival and fibrosis. This study however demonstrates that intraoperative application of MMC significantly reduces the cellular density of the filtration bleb.

De Holmgardia

Dedicatio: [Nikita] de Panin [ransk. pr.].

High-speed solid-rotor induction machine – calculation program

The aim of this thesis is to utilize the technology developed at LUT and to provide an easy tool for high-speed solid-rotor induction machine preliminary design. Computer aided design tool MathCAD has been chosen as the environment for realizing the calculation program. Four versions of the design program have been made depending on the motor rotor type. The first rotor type is an axially slitted solid-rotor with steel end rings. The next one is an axially slitted solid-rotor with copper end rings. The third machine type is a solid rotor with deep, rectangular copper bars and end rings (squirrel cage). And the last one is a solid-rotor with round copper bars and end rings (squirrel cage). Each type of rotor has its own specialties but a general thread of design is common. This paper follows the structure of the calculating program and explains some features and formulas. The attention is concentrated on the difference between laminated and solid-rotor machine design principles. There is no deep analysis of the calculation ways are presented. References for all solution methods appearing during the design procedure are given for more detailed studying. This thesis pays respect to the latest innovations in solid-rotor machines theory. Rotor ends’ analytical calculation follows the latest knowledge in this field. Correction factor for adjusting the rotor impedance is implemented. The purpose of the created design program is to calculate the preliminary dimensions of the machine according to initial data. Obtained results are not recommended for exact machine development. Further more detailed design should be done in a finite element method application. Hence, this thesis is a practical tool for the prior evaluating of the high-speed machine with different solid-rotor types parameters.

Apua Kekkoselle vai kansainvälisen politiikan sivutuote? Noottikriisin suomalainen kuva

Tutkimus käsittelee noottikriisin suomalaista kuvaa. Noottikriisi on saanut nimensä Neuvostoliiton Suomelle 30.10.1961 antamasta nootista, jonka mukaan Länsi-Saksan aseellinen varustautuminen aiheutti sellaisen sotilaallisen uhkan, että vuoden 1948 yya-sopimuksen mukaiset sotilaalliset konsultaatiot olivat perusteltuja. Presidentti Urho Kekkonen ja pääministeri Nikita Hruštšov sopivat kuitenkin runsaan kolmen viikon kuluttua, ettei niitä pidetä. Noottikriisi on ollut hyvin kiistanalainen. Eniten on erimielisyyttä aiheuttanut nootin motiivi. Siksi tämän tutkimuksen pääaiheena ovat sen tulkinnat suomalaisten kirjoittamissa painetuissa teksteissä nootin jättämisen jälkeisestä päivästä vuoteen 2013. Erimielisyys johtuu pääasiassa käsityksestä, että noottia ei lähetetty Länsi-Saksan aiheuttaman uhkan takia vaan Kekkosen auttamiseksi vuoden 1962 presidentinvaaleissa. Tätä tulkintaa yksinään tai yhdistettynä yhteen tai useampaa muuhun tekijään on myös kannatettu eniten. Kekkonenkin ilmaisi päiväkirjassaan, että tarkoituksena oli hänen tukemisensa. Julkisuudessa hän ei kuitenkaan sanonut koskaan niin eksplisiittisesti. Erityinen piirre ovat vaihtelut huomattavan monen akateemisenkin kirjoittajan tulkinnoissa. Sama koskee sanomalehtiä. Monet nimesivät jälkeenpäin nootin tarkoitukseksi Kekkosen auttamisen, vaikka olivat aluksi kirjoittaneet jotain muuta. Ilmiö paljastaa että sanomalehdet harjoittivat heti nootin saapumisen jälkeen itsesensuuria.

Hysteresis Losses in Sintered NdFeB Permanent Magnets in Rotating Electrical Machines

Permanent magnet materials are nowadays widely used in the electrical machine manufacturing industry. Eddy current loss models of permanent magnets used in electrical machines are frequently discussed in research papers. In magnetic steel materials we have, in addition to eddy current losses, hysteresis losses when AC or a rotating flux travels through the material. Should a similar phenomenon also be taken into account in calculating the losses of permanent magnets? Actually, every now and then authors seem to assume that some significant hysteresis losses are present in rotating machine PMs. This paper studies the mechanisms of possible hysteresis losses in PMs and their role in PMs when used in rotating electrical machines.