990 resultados para H. L. A. Hart


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Conselho Nacional de Desenvolvimento Científico e Tecno³gico (CNPq)

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Conselho Nacional de Desenvolvimento Científico e Tecno³gico (CNPq)

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Conselho Nacional de Desenvolvimento Científico e Tecno³gico (CNPq)

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Conselho Nacional de Desenvolvimento Científico e Tecno³gico (CNPq)

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Conselho Nacional de Desenvolvimento Científico e Tecno³gico (CNPq)

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Conselho Nacional de Desenvolvimento Científico e Tecno³gico (CNPq)

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Conselho Nacional de Desenvolvimento Científico e Tecno³gico (CNPq)

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Amelogenesis imperfecta (AI) is a genetically heterogeneous group of diseases that result in defective development of tooth enamel. Mutations in several enamel proteins and proteinases have been associated with AI. The object of this study was to evaluate evidence of etiology for the six major candidate gene loci in two Brazilian families with AI. Genomic DMA was obtained from family members and all exons and exon-intron boundaries of the ENAM, AMBN, AMELX, MMP20, KLK4 and Amelotin gene were amplified and sequenced. Each family was also evaluated for linkage to chromosome regions known to contain genes important in enamel development. The present study indicates that the AI in these two families is not caused by any of the known loci for AI or any of the major candidate genes proposed in the literature. These findings indicate extensive genetic heterogeneity for non-syndromic AI.

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A search has been performed for long-lived particles that have stopped in the CMS detector, during 7TeV proton-proton operations of the CERN LHC. The existence of such particles could be inferred from observation of their decays when there were no protonproton collisions in the CMS detector, namely during gaps between LHC beam crossings. Using a data set in which CMS recorded an integrated luminosity of 4.0 fb -1, and a search interval corresponding to 246 hours of trigger live time, 12 events are observed, with a mean background prediction of 8:6 ± 2:4 events. Limits are presented at 95% confidence level on long-lived gluino and stop production, over 13 orders of magnitude of particle lifetime. Assuming the cloud model of R-hadron interactions, a gluino with mass below 640 GeV and a stop with mass below 340 GeV are excluded, for lifetimes between 10 μs and 1000 s.

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The first measurement of the charged component of the underlying event using the novel jet-area/median approach is presented for proton-proton collisions at centre-of-mass energies of 0.9 and 7 TeV. The data were recorded in 2010 with the CMS experiment at the LHC. A new observable, sensitive to soft particle production, is introduced and investigated inclusively and as a function of the event scale defined by the transverse momentum of the leading jet. Various phenomenological models are compared to data, with and without corrections for detector effects. None of the examined models describe the data satisfactorily. © 2012 SISSA.

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A search for a doubly-charged Higgs boson in pp collisions at √s=7 TeV is presented. The data correspond to an integrated luminosity of 4. 9 fb-1, collected by the CMS experiment at the LHC. The search is performed using events with three or more isolated charged leptons of any flavor, giving sensitivity to the decays of pair-produced triplet components Φ++Φ--, and Φ++Φ- from associated production. No excess is observed compared to the background prediction, and upper limits at the 95 % confidence level are set on the Φ++ production cross section, under specific assumptions on its branching fractions. Lower bounds on the Φ++ mass are reported, providing significantly more stringent constraints than previously published limits. © 2012 CERN for the benefit of the CMS collaboration.

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A measurement of the forward-backward asymmetry (AFB) of Drell-Yan lepton pairs in pp collisions at s=7TeV is presented. The data sample, collected with the CMS detector, corresponds to an integrated luminosity of 5fb-1. The asymmetry is measured as a function of dilepton mass and rapidity in the dielectron and dimuon channels. Combined results from the two channels are presented, and are compared with the standard model predictions. The AFB measurement in the dimuon channel and the combination of the two channels are the first such results obtained at a hadron collider. The measured asymmetries are consistent with the standard model predictions. © 2012 CERN.

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A search is presented for physics beyond the standard model (BSM) in final states with a pair of opposite-sign isolated leptons accompanied by jets and missing transverse energy. The search uses LHC data recorded at a center-of-mass energy s=7 TeV with the CMS detector, corresponding to an integrated luminosity of approximately 5 fb-1. Two complementary search strategies are employed. The first probes models with a specific dilepton production mechanism that leads to a characteristic kinematic edge in the dilepton mass distribution. The second strategy probes models of dilepton production with heavy, colored objects that decay to final states including invisible particles, leading to very large hadronic activity and missing transverse energy. No evidence for an event yield in excess of the standard model expectations is found. Upper limits on the BSM contributions to the signal regions are deduced from the results, which are used to exclude a region of the parameter space of the constrained minimal supersymmetric extension of the standard model. Additional information related to detector efficiencies and response is provided to allow testing specific models of BSM physics not considered in this Letter. © 2012 CERN.

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Results are presented from a search for a W' boson using a dataset corresponding to 5.0fb-1 of integrated luminosity collected during 2011 by the CMS experiment at the LHC in pp collisions at s=7TeV. The W' boson is modeled as a heavy W boson, but different scenarios for the couplings to fermions are considered, involving both left-handed and right-handed chiral projections of the fermions, as well as an arbitrary mixture of the two. The search is performed in the decay channel W'→tb, leading to a final state signature with a single electron or muon, missing transverse energy, and jets, at least one of which is identified as a b-jet. A W' boson that couples to the right-handed (left-handed) chiral projections of the fermions with the same coupling constants as the W is excluded for masses below 1.85 (1.51) TeV at the 95% confidence level. For the first time using LHC data, constraints on the W' gauge couplings for a set of left- and right-handed coupling combinations have been placed. These results represent a significant improvement over previously published limits. © 2012 CERN.

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Conselho Nacional de Desenvolvimento Científico e Tecno³gico (CNPq)