An address, in commemoration of the sixth of September, 1781. Spoken on Groton Heights, Sept. 6, 1825.

Shaw and Shoemaker 19850

The geology of Groton State Forest.

Mode of access: Internet.

Biotic interactions recorded in shells of recent rhynchonelliform brachiopods from San Juan Island, USA

Biotic interactions between brachiopods and spionid polychaete worms, collected around San Juan Islands (USA), were documented using observations from live-collected individuals and traces of bioerosion found in dead brachiopod shells. Specimens of Terebratalia tranversa (Sowerby), Terebratulina unguicula (Carpenter), Laqueus californianus (Koch), and Hemithiris psittacea (Gmelin) were collected from rocky and muddy substrates, from sites ranging from 14.7-93.3 m in depth. Out of 1,131 specimens, 91 shells showed traces of bioerosion represented by horizontal tubes. Tubes are U-shaped, straight or slightly curved, sometimes branched, with both tube openings communicating externally. on internal surfaces of infested shells, blisters are observed. All brachiopod species yielded tubes, except for H. psittacea. Tubes are significantly more frequent on live specimens, and occur preferentially on larger, ventral valves. This pattern suggests selectivity by the infester rather than a taphonomic bias. Given the mode of life of studied brachiopods (epifaunal, sessile, attached to the substrate, lying on dorsal valve), ventral valves of living specimens should offer the most advantageous location for suspension-feeding infesters. Frequent infestation of brachiopods by parasitic spionids is ecologically and commercially noteworthy because farmed molluscs are also commonly infested by parasitic polychaetes. In addition, brachiopod shells are among the most common marine macroscopic fossils found in the Phanerozoic fossil record. From a paleontological perspective, spionid-infested brachiopod shells may be a prime target for studying parasite-host interactions over evolutionary time scales.

ONTOGENETIC DEVELOPMENT OF SENSORY STRUCTURES ON THE ANTENNULES AND ANTENNAE OF THE GIANT RIVER PRAWN MACROBRACHIUM ROSENBERGII (DE MAN)

In this study the occurrence of sensory structures on the antennules and antennae of the giant river prawn Macrobrachium rosenbergii (De Man) during postembryonic ontogenetic development were examined. Larvae and postlarvae were obtained from hatchery recirculating tanks, juveniles from indoor nursery tanks, and adults from earthen grow-out ponds. The animals were fixed with Karnovsky fixative and dissected. Antennules and antennae were removed, metal-coated, and photodocumented using a scanning electron microscope. The antennules have aesthetascs and simple plumose and pappose setae; the antennae have simple, plumose and pappose setae. These structures increase in density, covered surface, and distribution during ontogeny and should be related to chemoreception and mechanoreception. The antennular statocyst that appears during larval stage VII of the giant river prawn has an array of sensory structures that enable the perception of chemical and tactile stimuli beginning with its early life stages. The ontogenetic changes observed allow an inference that initial-stage larvae, advance-stage larvae, juveniles, and adults have different capacities to exploit the environment.

CLONING AND EXPRESSION ANALYSIS OF ALLOGRAFT INFLAMMATORY FACTOR TYPE 1 IN COELOMOCYTES OF ANTARCTIC SEA URCHIN (STERECHINUS NEUMAYERI)

We have cloned and characterized for the first time an allograft inflammatory factor 1 (Sn-AIF-1) from the Antarctic sea urchin. We report the cloning of Sn-AIF-1 cDNA and the characterization of its expression in coelomocytes after a bacterial challenge. The cDNA Sn-AIF-1 has a size of 608 bp and encodes a polypeptide of 151 aa. The deduced amino acid sequence has a putative size of 17.430 Da, an isoelectric point of 4.92, and shows 2 elongation factor handlike motifs that normally bind calcium ions. BLAST analysis revealed close matches with other known AIF-1. The deduced amino acid sequence of Sn-AIF-1 showed high homology with AIF-1 in vertebrates such as fish, mice, and humans; and in the case of invertebrates, the major degree of identity (55%) was with a predicted sequence of the purple sea urchin AIF-1, and 52% corresponded to a sponge. Expression of Sn-AIF-1 mRNA was analyzed by qPCR. Sn-AIF-1 mRNA expression was measured from coelomocytes after a bacterial challenge using RT-PCR and revealed that the gene was upregulated after 24 h. Sn-AIF-1 could participate in the inflammatory response, particularly in the activation of coelomocytes and their survival.

Diagnosing the Prodromal State of Alzheimer's Disease

Mild Cognitive Impairment- Amnestic Subtype (MCIa) is a putative prodromal stage of Alzheimer’s Disease (AD) characterized by focal deficits in episodic verbal memory. Less is known about relative deficits in visuospatial learning, although there is ample evidence indicating involvement of the hippocampus in visuospatial learning, as well as hippocampal degeneration in early AD. The aim of this study was to better characterize the components of working memory dysfunction in people with MCIa to increase the ability to reliably diagnose this disease. Fifty-six elderly adults diagnosed with MCIa and 94 healthy elderly completed a hidden maze learning task. Results indicated similar functioning between groups on measures of reasoning, problem solving, and accuracy. However, MCIa subjects were less efficient at learning the hidden path, making more errors per second on average (Cohen’s d= -.78) and requiring a longer time to complete the maze (Cohen’s d=.77). The learning curve between the first two trials was four times as steep for healthy elderly compared to MCIa (slopes = 4.9 vs. 1.24, respectively), indicating that MCIa subjects exhibited relative difficulty in holding and making effective use of an internal spatial map in order to improve performance. Our results suggest that MCIa patients have focal deficits in visuospatial working memory, with relative preservation of functioning on other more global measures of cognitive functioning. This particular pattern of results may be specific to the amnestic variant of MCI.

Docket books and fee book, 1791-1806

Consists of 7 notebooks and 1 account book. Notebooks list cases heard before the Massachusetts Court of Common Pleas for Middlesex and Worcester counties and the Massachusetts Supreme Judicial Court (March 1794-Sept. 1797; Sept. 1800-March 1802; June 1805-September 1806) and before the New Hampshire Court of Common Pleas for Hillsborough and Merrimack counties (March 1798-March 1805). The account book includes cases from Sept. 1791-July 1797.

Docket and fees book / 1791-1797

Records of cases heard in the Massachusetts Court of Common Pleas (Middlesex Co.) in Cambridge, Mass., and the New Hampshire Inferior Court of Common Pleas (Hillsborough Co.) in Amherst, N.H and matters brought before justices of the peace. Records identify the litigants, with some notes on fees and settlements; many of the cases concern debts. Justices of the peace include: Israel Atherton (Lancaster, Mass.); Samuel Dana (Amherst, N.H.); Joshua Longley (Shirley, Mass.); Nathaniel Paine (Worcester, Mass.); James Prescott (Westford, Mass.); Jeremiah Stiles (Keene, N.H.); William Swan (Groton, Mass.); Sampson Tuttle (Littleton, Mass.); and Henry Woods (Pepperell, Mass.).

Certification of payment from Oliver Prescott, 1747 September 23

Handwritten certificate of payment for a new red and plaid gown purchased by Harvard sophomore Oliver Prescott in 1747. The certificate is witnessed by upperclassmen Artemas Ward, Jacob Cushing, and Timothy Pond.

Account book, ca. 1783-1820

Oblong notebook recording payments by William Bridge to various parties in Chelmsford, Tyngsborough, Groton and Dunstable, in Middlesex County, Massachusetts in the early 19th century. Bridge also records legal duties such as serving writs, and activities such as making hay and slaughtering livestock for or with other individuals which may indicate debt and payment. Elsewhere he records the birthdates of himself and his siblings and the deaths of his parents. Also included is a recipe to cure an ailing horse.

Gravitatio est in Ratione Quantitatum Materia : 1750

One-page sheet with a handwritten Latin thesis defended by graduate Oliver Prescott in the 1750 Harvard College Commencement ceremony. The document is signed: "H. College July 3, 1750 Oliver Prescott. Verso: "Theses read when I took my degree 1750."

Hope: a poem delivered at an exhibition in Cambridge, July 10, 1800

This four-page handwritten poem was composed by Harvard student Joseph Mansfield for a College exhibition on July 8, 1800. The poem begins, "I am not blesd, but may hereafter be; / Who knows what fortune has in store for me?" and concludes with verses about the American Revolutionary War and George Washington.

Letter from Samuel Willard, Harvard College, Cambridge, Massachusetts, to William Willard, Petersham, Massachusetts, November 30, 1802

Willard discusses President Willard’s son Sheafe, who he has been tutoring, explains his education and argues for well-rounded studies. He also mentions that Doctor Aaron Dexter, a lecturer on chemistry, gave him a recipe for paint “which I enclose [separately] in this letter,” as well as a recipe for mortar. He explains that his vacation plans are to teach at a school in Groton for eighteen dollars a month, and asks for a loan from his parents to pay a bill.

Papers of William Merchant Richardson, 1797-1806

The collection contains a four-page handwritten poem titled "Invention" composed by graduate William Richardson for the 1797 Harvard College Commencement, and an 1806 letter of introduction written by Richardson. The rhyming poem begins, “Long had creations anthem peal been rung…” and contains classical references, and mentions scientists and philosophers including Voltaire, Franklin and Newton. The poem is accompanied by a one-page handwritten letter of introduction for lawyer Benjamin Ames (Harvard AB 1803) written by William M. Richardson to Reverend William Jenks (Harvard AB 1797). The letter is dated November 10, 1806.

New Hampshire, 1816 (Image 5 of 6) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: New Hampshire by recent survey : made under the supreme authority and published according to law by Philip Carrigain ; J.J. Barralet, del. ; W. Harrison, sct., Philada. It was published by Philip Carrigain in 1816. Scale [ca. 1:200,000]. This layer is image 5 of 6 total images, representing the center west portion of the six sheet source map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the New Hampshire State Plane coordinate system (NAD 1983 in Feet) (Fipszone 2800). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, public buildings, schools, churches, industry locations (e.g. mills, factories, mines, etc.), selected private buildings with names of property owners, town boundaries, land grants, and more. Relief shown pictorially and by hachures. Includes area notes, text, and table of population. Also includes illustrations: View of the Great Boars Head and Hampton Beach -- The Cap of the White Mountains -- View of the White Mountains from Shelburne; inset maps: States of the Union east of the Hudson with the adjacent British colonies. Scale [ca. 1:1,920,000] -- The middle, southern and western sections of the United States with the territories. Scale [ca. 1:4,900,000]. Includes: ms. additions with updated county boundary & township names.This layer is part of a selection of digitally scanned and georeferenced historic maps of New England from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates, scales, and map purposes.