Bioinformática: identificar genes en una interfaz gráfica vía web para la comparación de genomas

Este trabajo desarrolla el proceso de diseño e implementación de una interfaz web que permite la exploración en detalle de las relaciones entre genomas completos. La interfaz permite la comparación simultánea de nueve genomas, representando en cada gráfica las relaciones entre cada par de genomas junto los genes identificados de cada uno de ellos. Es capaz de trabajar con genomas del dominio Eukaryota y se adapta a la capacidad de cómputo de la máquina cliente. La información representada son MUMs (Maximal Unique Matching, secuencia máxima y única encontrada en ambos genomas) y SuperMUMs (agrupación de MUMs mediante Approximate String Matching). Los datos son previamente calculados y accesibles desde un servidor web.

Improving Short DNA Sequence Alignment with Parallel Computing

Variations in different types of genomes have been found to be responsible for a large degree of physical diversity such as appearance and susceptibility to disease. Identification of genomic variations is difficult and can be facilitated through computational analysis of DNA sequences. Newly available technologies are able to sequence billions of DNA base pairs relatively quickly. These sequences can be used to identify variations within their specific genome but must be mapped to a reference sequence first. In order to align these sequences to a reference sequence, we require mapping algorithms that make use of approximate string matching and string indexing methods. To date, few mapping algorithms have been tailored to handle the massive amounts of output generated by newly available sequencing technologies. In otrder to handle this large amount of data, we modified the popular mapping software BWA to run in parallel using OpenMPI. Parallel BWA matches the efficiency of multithreaded BWA functions while providing efficient parallelism for BWA functions that do not currently support multithreading. Parallel BWA shows significant wall time speedup in comparison to multithreaded BWA on high-performance computing clusters, and will thus facilitate the analysis of genome sequencing data.

Antitrust on the ‘G string’: What’s behind the Commission’s investigations of Google and Gazprom? CEPS Commentary, 15 June 2015

The past few weeks have marked a shift of gear in EU antitrust enforcement. First, the new European Commissioner for Competition Margarethe Vestager announced on April 15th that the Commission had sent a Statement of Objections to Google, arguing that the giant IT company abused its dominant position in the “general Internet search” market and also in the market for mobile operating systems, apps and services. Exactly one week later, she also sent a Statement of Objections to Gazprom for having created artificial barriers to trade between certain EU countries, preventing gas flows and competition across national borders and charging unfair prices in five Central and Eastern European countries. It is indeed hard to recall any other time in which two investigations of this size – both potentially leading to billions of euros of fines – have been launched almost simultaneously.

Basic principles of violin playing : a report prepared for the MENC Committee on String Instruction in the Schools

Mode of access: Internet.

The Star collection of instrumental music; arranged for wind and string instruments, and for the use of small bands and orchestras.

Contains arrangements of songs, selections from operas, dances, etc.

Streichquartett, op. 54 no. 1, G moll = [music] : String quartet, G minor /

Duration: ca.. 25 min.

Concerto grosso for string orchestra, no. 5, D major. [music] /

"Edition Eulenburg, no. 268".

Two sketches for string quartet based on Indian themes.

Mode of access: Internet.

Molly on the shore; Irish reel on 2 Cork reel tunes set for string four-some or string band.

For 2 violins, viola, violoncello.

String quartet (dedicated to his colleagues of the Philharmonic String Quartet) Op. 14.

Mode of access: Internet.

"The Pickwick club," a humoreske in two parts. String quartet [no. 3] (Op. 68)

"Synopsis" ([4] p.) inserted.

String quartet no. 22 (9) in B flat major, K 589. [music] /

Mode of access: Internet.

String quartet no. 20 (7) in D major, K 499. [music] /

Mode of access: Internet.