Expression of DFak56, a Drosophila homolog of vertebrate focal adhesion kinase, supports a role in cell migration in vivo

Focal adhesion kinase (FAK) is a highly conserved, cytoplasmic tyrosine kinase that has been implicated in promoting cell migration and transmission of antiapoptotic signals in vertebrate cells. In cultured cells, integrin engagement with the extracellular matrix promotes the recruitment of FAK to focal contacts and increases in its phosphotyrosine content and kinase activity, suggesting FAK is an intracellular mediator of integrin signaling. We have identified a Drosophila FAK homolog, DFak56, that is 33% identical to vertebrate FAK, with the highest degree of homology in domains critical for FAK function, including the kinase and focal adhesion targeting domains, and several protein–protein interaction motifs. Furthermore, when expressed in NIH 3T3 cells, DFak56 both localizes to focal contacts and displays the characteristic elevation of phosphotyrosine content in response to plating the cells on fibronectin. During embryogenesis, DFak56 is broadly expressed, and it becomes elevated in the gut and central nervous system at later stages. Consistent with a role in cell migration, we also observe that DFak56 is abundant in the border cells of developing egg chambers before the onset of, and during, their migration.

Grotte, labyrinthe, fontaines et bassins de Versailles.

This volume has been designated "sixième volume" in the Catalogue, for a collection known under the title of the repository, Cabinet du roi. The engravings were prepared between 1672 and 1689 by various engravers: Le Pautre, Le Clerc, Chauveau, Edelinck, Picart, Baudet, Silvestre, Simonneau and Chatillon. They were issued individually at the outset, collected, and in this instance issued in uniform format. The plates of the Labyrinthe, 15 x 8.5 cm., have been printed on 4 leaves of 9 and 1 leaf of 5.

Resumen historial de las grandezas y antiguedades de la Ciudad de Gerona : y cosas memorables suyas eclesiasticas y seculares ..., vida, martyrio ... de San Narciso ... y defensa de la entrada de Carlos el Grande en Cataluña en una carta apologetica ... /

Carta apologetica por la entrada de Carlos el grande en Cataluña / escrita por F. Iuan Gaspar Roig y Ialpi ...

Dulze desengaño historico, del año cierto en que se fundò la Sagrada ... Orden de Nuestra Señora de la Merced Redencion de Cautiuos, por el ... rey don Iayme el Grande ... /

Mode of access: Internet.

The history of Pontefract, in Yorkshire /

Purchased from Gilman, Crompond, N.Y.

1954 University of Michigan Football Team

Map showing where Sandia points were found in Cass County

Caption: Map from the Directory of Cass County 1953-1954 Compiled by Floyd Wagner, County Clerk of Cass County [blue dot] for each find

Defensio antiquitatis regalis Scotorum prosa-apiae...

Mode of access: Internet.

The study of history in schools; report to the American historical association

Mode of access: Internet.

Reminiscences,

Mode of access: Internet.

The Interpretation of the scripture passage, the "more sure word of prophesy, &c.," 2 Peter, Chap. i., Verse 19, as given by George Fox, William Penn, Robert Barclay, George Whitehead, Francis Howgill, Samuel Fisher, and James Parnel in reply to opposers : also extracts from the writings of Ambrose Rigge, William Bayly, Charles Marshall, Josiah Coale, Margaret Fox, and Elizabeth Bathurst, on the same subject.

Cover title.

George Fox and Clarence Ufer, UM Track , 1915

[Ensian caption: "The fighting face" of the cinder track. Fox and Ufer leading the runners in the back stretch.]

A declaration of the views of the Society of Friends : in relation to church government. Compiled principally from the writings of George Fox, Stephen Crisp, Robert Barclay and William Penn.

Smith I:770.