Prevenção da repetição de episódos de reação tipo 2 da Hanseníase com o uso da talidomida na dose de 100mg/dia

Introdução: A hanseníase é doença crônica que pode ter seu curso interrompido por episódios reacionais tipo 1 e 2 ou ENH, sendo que estes podem ser repetitivos, com conseqüentes danos ao paciente.A talidomida é a medicação de eleição para o controle, desde 1965. Objetivo: Evitar repetição de episódios reacionais. Material e Método: Após o controle da reação com dose tradicional, utilizou-se 100mg/d, pelo período de seis meses, com acompanhamento por seis meses após a suspensão. Resultados: Foram avaliados 42 pacientes MB, 39 (92,85%) da forma V e 3(7,15%) da D, que apresentaram ENH, como primeiro episódio ou repetição, 33(78,6%) do sexo masculino e9(21,4%) do feminino. As idades variaram de 18 a 84 anos, predomínio acima de 49 anos.Não se observou repetição em 100% dos pacientes durante o uso dessa dose.Durante a observação clinica, 33(78,6%)continuaram sem apresentar reação e9(21,4%), todos da forma V,a apresentaram, de forma leve,sem sinais e sintomas, controlada com antinflamatórios não hormonais. Não houve efeitos adversos. Conclusões: sugere-se o uso da talidomida, 100mg/ dia, como manutenção, que foi efetiva, impedindo a repetição das reações tipo 2.

Near-Term Fetal Hypoxia-Ischemia in Rabbits MRI Can Predict Muscle Tone Abnormalities and Deep Brain Injury

Background and Purpose-The pattern of antenatal brain injury varies with gestational age at the time of insult. Deep brain nuclei are often injured at older gestational ages. Having previously shown postnatal hypertonia after preterm fetal rabbit hypoxia-ischemia, the objective of this study was to investigate the causal relationship between the dynamic regional pattern of brain injury on MRI and the evolution of muscle tone in the near-term rabbit fetus. Methods-Serial MRI was performed on New Zealand white rabbit fetuses to determine equipotency of fetal hypoxia-ischemia during uterine ischemia comparing 29 days gestation (E29, 92% gestation) with E22 and E25. E29 postnatal kits at 4, 24, and 72 hours after hypoxia-ischemia underwent T2- and diffusion-weighted imaging. Quantitative assessments of tone were made serially using a torque apparatus in addition to clinical assessments. Results-Based on the brain apparent diffusion coefficient, 32 minutes of uterine ischemia was selected for E29 fetuses. At E30, 58% of the survivors manifested hind limb hypotonia. By E32, 71% of the hypotonic kits developed dystonic hypertonia. Marked and persistent apparent diffusion coefficient reduction in the basal ganglia, thalamus, and brain stem was predictive of these motor deficits. Conclusions-MRI observation of deep brain injury 6 to 24 hours after near-term hypoxia-ischemia predicts dystonic hypertonia postnatally. Torque-displacement measurements indicate that motor deficits in rabbits progressed from initial hypotonia to hypertonia, similar to human cerebral palsy, but in a compressed timeframe. The presence of deep brain injury and quantitative shift from hypo-to hypertonia may identify patients at risk for developing cerebral palsy. (Stroke. 2012;43:2757-2763.)

Die gestempelten Bronze-Gewichte aus Himera

Bei Ausgrabungen in der antiken griechischen Stadt Himera an der Nordküste Siziliens wurden zwei Bronzegewichte gefunden. Beide zeigen eine Beprägung , die dasselbe Prägebild wie die Rückseite zeitgleicher Litraprägungen aus Himera wiedergeben. Im Jahr 2010 erschien im Münzhandel zudem ein zuvor unveröffentlichtes Bronzegewicht, beprägt mit einem Hemilitron-Rückseitenstempel aus Himera. Anhand dieser gestempelten Bronzegewichte können – unter Einbezug weiterer Quellen – die im letzten Viertel des 5. Jhs. v. Chr. in Himera üblichen Gewichtssysteme für Bronze nachgezeichnet werden: Neben einer überregionalen, kanonischen Bronze-Litra, die bereits früher im 5. Jh. v. Chr. von ca. 108 g auf ca. 216 g im Gewicht verdoppelt worden war, scheint ein regionaler Litrafuß zu ca. 50 g etabliert gewesen zu sein. Dieser den frühesten Bronzemünzen von Himera, Selinunt und Akragas zugrundeliegende Litrafuß existierte auch dann noch, als die Münzen bereits in stark reduziertem Gewicht geprägt wurden.

Transit-supportive development in the United States: experiences and prospects. Final report.

Federal Transit Administration, Washington, D.C.

Bus and passenger accident prevention. Final report.

Federal Transit Administration, Washington, D.C.

Estudo paramétrico da injeção de polímeros em reservatórios de petróleo

Developing an efficient methodology for oil recovery is extremely important . Within the range of enh anced oil recovery, known as EOR, the injection of polymer solutions becomes effective in controlling the mobility of displacing fluid . This method consists of adding polymers to the injection water to increase its viscosity, so that more water diffuses in to the porous medium and increasing the sweep efficiency in the reservoir. This work is studied by numerical simulation , application of the injection polymer solution in a homogeneous reservoir , semisynthetic with similar characteristics to the reservoirs of the Brazilian Northeast , numerical simulations were performed using thermal simulator STARS from CMG (Computer Modelling Group ). The study aimed to analyze the influence of some parameters on the behavior of reservoir oil production, with the response to cumulative production. Simulations were performed to analyze the influence of water injection, polymer solution and alternating injection of water banks and polymer solution, comparing the results for each simulated condition. The primary outcomes were: oil viscosity, percentage of injected polymer, polymer viscosity and flow rate of water injection. The evaluation of the influence of variables consisted of a complete experimental design followed a Pareto analysis for the purpose of pointing out which va riables would be most influential on the response represented b y the cumulative oil production . It was found that all variables significantly influenced the recovery of oil and the injection of polymer solution on an ongoing basis is more efficient for the cumulative production compared to oil recovery by continuous water injection. The primary recovery show ed low levels of oil production , water injection significantly improves the pro duction of oil in the reservoir , but the injection of polymer solution em erges as a new methodology to increase the production of oil, increasing the life of the well and possible reduction of water produced.

Una propuesta de empalme de las encuestas de hogares basada en la tasa de desempleo

El análisis acerca de los cambios de metodología entre la Encuesta Nacional de Hogares (ENH) y la Encuesta Continua de Hogares (ECH), permite ver una ruptura en el estudio de los indicadores del mercado laboral que justifica el desarrollo de una propuesta de empalme para las variables utilizadas en el cálculo de los indicadores del mercado laboral. Particularmente, este artículo trabaja el empalme de la serie de la tasa de desempleo nacional a siete Áreas Metropolitanas desde marzo de 1985 hasta diciembre de 2003, basándose en el cálculo de un factor de corrección definitivo que es el producto de dos factores de corrección: uno por definición y otro por recolección, tal como lo presentaron Suárez y Buriticá (2004). Los resultados del empalme muestran que la serie corregida disminuye aproximadamente 0.46 puntos porcentuales, con respecto a la serie original. Asimismo, muestran que sólo es posible utilizar las ECH del año 2000 y el primer trimestre del 2001 para empalmar las series.

Novas propriedades do SKTI (Inibidor de tripsina de soja): inibição para elastase neutrofílica humana e efeitos no processo de injúria pulmonar aguda

Seeds from legumes including the Glycine max are known to be a rich source of protease inhibitors. The soybean Kunitz trypsin inhibitor (SKTI) has been well characterised and has been found to exhibit many biological activities. However its effects on inflammatory diseases have not been studied to date. In this study, SKTI was purified from a commercial soy fraction, enriched with this inhibitor, using anion exchange chromatography Resource Q column. The purified protein was able to inhibit human neutrophil elastase (HNE) and bovine trypsin. . Purified SKTI inhibited HNE with an IC50 value of 8 µg (0.3 nM). At this concentration SKTI showed neither cytotoxic nor haemolytic effects on human blood cell populations. SKTI showed no deleterious effects on organs, blood cells or the hepatic enzymes alanine amine transferase (ALT) and aspartate amino transferase (AST) in mice model of acute systemic toxicity. Human neutrophils incubated with SKTI released less HNE than control neutrophils when stimulated with PAF or fMLP (83.1% and 70% respectively). These results showed that SKTI affected both pathways of elastase release by PAF and fMLP stimuli, suggesting that SKTI is an antagonist of PAF/fMLP receptors. In an in vivo mouse model of acute lung injury, induced by LPS from E. coli, SKTI significantly suppressed the inflammatory effects caused by elastase in a dose dependent manner. Histological sections stained by hematoxylin/eosin confirmed this reduction in inflammation process. These results showed that SKTI could be used as a potential pharmacological agent for the therapy of many inflammatory diseases

Polimorfismos nos genes ERBB2 e PARK2/PACRG e sua associação com a hanseníase em populações do Rio Grande do Norte e Pará

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Avaliação das atividades anti-inflamatória, anticoagulante e antiproliferativa do inibidor de quimotripsina das sementes de erythrina velutina (EvCI)

Studies indicate that several components were isolated from medicinal plants, which have antibacterial, antifungal, antitumor and anti-inflammatory properties. Sepsis is characterized by a systemic inflammation which leads to the production of inflammatory mediators exacerbated by excessive activation of inflammatory cells and disseminated intravascular coagulation (DIC), in which the human neutrophil elastase plays an important role in its pathogenesis. Several epidemiological studies suggest that components of plants, especially legumes, can play a beneficial role in reducing the incidence of different cancers. A chymotrypsin inhibitor of Kunitz (Varela, 2010) was purified from seeds of Erythrina velutina (Mulungu) by fractionation with ammonium sulfate, affinity chromatography on Trypsin-Sepharose, Chymotrypsin-Sepharose and ion exchange chromatography on Resource Q 1 ml (GE Healthcare) in system FPLC / AKTA. The inhibitor, called EvCI, had a molecular mass of 17 kDa determined by SDS-PAGE. The purified protein was able to inhibit human neutrophil elastase (HNE), with an IC50 of 3.12 nM. The EvCI was able to inhibit both pathways of HNE release stimulated by PAF and fMLP (75.6% and 65% respectively). The inhibitor also inhibited leukocyte migration in septic mice about 87% and prolonged the time of coagulation and inhibition factor Xa. EvCI showed neither hemolytic activity nor cytotoxicity. EvCI showed a selective antiproliferative effect to HepG2 cell lines with IC50 of 0.5 micrograms per milliliter. These results suggest EvCI as a molecule antagonist of PAF / fMLP and a potential use in fighting inflammation related disorders, disseminated intravascular coagulation (DIC) and cancer