Karl Popper's Philosophy of Science - And the Evolution of the Popperian Worlds

This doctoral thesis in theoretical philosophy is a systematic analysis of Karl Popper's philosophy of science and its relation to his theory of three worlds. The general aim is to study Popper's philosophy of science and to show that Popper's theory of three worlds was a restatement of his earlier positions. As a result, a new reading of Popper's philosophy and development is offered and the theory of three worlds is analysed in a new manner. It is suggested that the theory of three worlds is not purely an ontological theory, but has a profound epistemological motivation. In Part One, Popper's epistemology and philosophy of science is analysed. It is claimed that Popper's thinking was bifurcated: he held two profound positions without noticing the tension between them. Popper adopted the position called the theorist around 1930 and focused on the logical structure of scientific theories. In Logik der Forschung (1935), he attempted to build a logic of science on the grounds that scientific theories may be regarded as universal statements which are not verifiable but can be falsified. Later, Popper emphasized another position, called here the processionalist. Popper focused on the study of science as a process and held that a) philosophy of science should study the growth of knowledge and that b) all cognitive processes are constitutive. Moreover, the constitutive idea that we see the world in the searchlight of our theories was combined with the biological insight that knowledge grows by trial and error. In Part Two, the theory of three worlds is analysed systematically. The theory is discussed as a cluster of theories which originate from Popper's attempt to solve some internal problems in his thinking. Popper adhered to realism and wished to reconcile the theorist and the processionalist. He also stressed the real and active nature of the human mind, and the possibility of objective knowledge. Finally, he wished to create a scientific world view.

Karl Gottschalk and Elisbeth nee Steinfeld with their son Rudolf Gottschalk (later Grahame) and son Fritz Gottschalk (Levy) of Lisbeth's first marriage.

Rudolf Gottschalk (later Grahame) on right; Fritz Gottschalk (Levy) on left

Portrait of Karl Gottschalk.

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Karl Gottschalk and Elisbeth nee Steinfeld with their son Rudolf Gottschalk (later Grahame) and son Fritz Gottschalk (Levy) of Lisbeth's first marriage.

Rudolf Gottschalk (later Grahame) on right; Fritz Gottschalk (Levy) on left

House of Karl Gottschalk on Richard-Wagner-Strasse; Hannover, Germany.

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House of Karl Gottschalk on Richard-Wagner-Strasse; Hannover, Germany.

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Portrait of Walter Godshaw, Charlie Sloan (Karl-Hermann Solomon), and Ida, Kaete Solomon's maid; Hannover, Germany.

From left to right: Walter Gottschalk, Ida, Charlie Sloan (Karl Hermann Solomon); Ida, Kaete Solomon's maid, nursed Charlie back to health after his release from Dachau

Portrait of Walter Godshaw, Charlie Sloan (Karl-Hermann Solomon), and Ida, Kaete Solomon's maid; Hannover, Germany.

From left to right: Walter Gottschalk, Ida, Charlie Sloan (Karl Hermann Solomon); Ida, Kaete Solomon's maid, nursed Charlie back to health after his release from Dachau

New genetic loci link adipose and insulin biology to body fat distribution

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10−8). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.

Portrait of Austrian writer Karl Kraus reading and holding a cigar; Berlin Portraits Men

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Reproduction of photograph of Kurt Fritz Rosenberg (left) with Karl Kaufman and Elsa Kaufman; Dresden.

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Reproduction of painted portrait by Eduard Magnus of Mrs. Karl Steffeck Portraits Women

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Portrait of Karl Gottschalk.

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House of Karl Gottschalk on Richard-Wagner-Strasse; Hannover, Germany.

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