Iris Murdoch e Simone de Beauvoir: uma leitura feminista de A fairly honourable defeat e La femme rompue

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Effects of minor laboratory procedures, adrenalectomy, social defeat or acute alcohol on regional brain concentrations of corticosterone

Concentrations of corticosterone in brain areas of TO strain mice were measured by radioimmunoassay. The studies examined the effects of routine laboratory maneuvers, variation during the circadian peak, adrenalectomy, social defeat and acute injections of alcohol on these concentrations. Brief handling of mice increased corticosterone levels in plasma but not in striatum and reduced those in the hippocampus. Single injections of isotonic saline raised the plasma concentrations to a similar extent as the handling, but markedly elevated concentrations in the three brain regions. Five minutes exposure to a novel environment increased hippocampal and cerebral cortical corticosterone levels and striatal concentrations showed a larger rise. However, by 30 min in the novel environment, plasma concentrations rose further while those in striatum and cerebral cortex fell to control levels and hippocampal corticosterone remained elevated. Over the period of the circadian peak the hippocampal and striatal concentrations paralleled the plasma concentrations but cerebral cortical concentrations showed only small changes. Adrenalectomy reduced plasma corticosterone concentrations to below detectable levels after 48 h but corticosterone levels were only partially reduced in the hippocampus and striatum and remained unchanged in the cerebral cortex. Single or repeated social defeat increased both brain and plasma concentrations after 1 h. Acute injections of alcohol raised the regional brain levels in parallel with plasma concentrations. The results show that measurements of plasma concentrations do not necessarily reflect the levels in brain. The data also demonstrate that corticosterone levels can change differentially in specific brain regions. These results, and the residual hormone seen in the brain after adrenalectomy, are suggestive evidence for a local origin of central corticosterone.

Multiple avirulence paralogues in cereal powdery mildew fungi may contribute to parasite fitness and defeat of plant resistance

Powdery mildews, obligate biotrophic fungal parasites on a wide range of important crops, can be controlled by plant resistance (R) genes, but these are rapidly overcome by parasite mutants evading recognition. It is unknown how this rapid evolution occurs without apparent loss of parasite fitness. R proteins recognize avirulence (AVR) molecules from parasites in a gene-for-gene manner and trigger defense responses. We identify AVRa10 and AVRk1 of barley powdery mildew fungus, Blumeria graminis f sp hordei (Bgh), and show that they induce both cell death and naccessibility when transiently expressed in Mla10 and Mlk1 barley (Hordeum vulgare) varieties, respectively. In contrast with other reported fungal AVR genes, AVRa10 and AVRk1 encode proteins that lack secretion signal peptides and enhance infection success on susceptible host plant cells. AVRa10 and AVRk1 belong to a large family with mayor que30 paralogues in the genome of Bgh, and homologous sequences are present in other formae speciales of the fungus infecting other grasses. Our findings imply that the mildew fungus has a repertoire of AVR genes, which may function as effectors and contribute to parasite virulence. Multiple copies of related but distinct AVR effector paralogues might enable populations of Bgh to rapidly overcome host R genes while maintaining virulence.

Reinterpreting Coatlicue : the Sculptural Narrative of Defeat at the Shrine of Huitzilopochtli

"Images of the decapitated, dismembered female warrior Coyolxauhqui, a main character in the Mexica mythology of Huitzilopochtli, figured prominently in Imperial Mexica sculptural campaigns at the Templo Mayor. However, monoliths of a terrifying, dismembered female from the shrine have traditionally been identified as Huitzilopochtli’s nurturing mother Coatlicue, or permutations of goddesses. Such studies do not adequately address why these sculptures depict mutilated beings whose characteristics are antithetical to Coatlicue’s appropriate female behavior depicted in myths and images"

The European Resonance of Napoleon’s Defeat in Spain

The military event that sealed the defeat of Napoleon in Spain was the Battle of Vitoria on 21st June 1813, which saw the allied British, Spanish and Portuguese troops led by Wellington gain victory over Joseph Bonaparte's forces. It was the last great battle of what is known in Spain as the Guerra de la Independencia, in the United Kingdom as the Peninsular War and in France as the Guerre d'Espagne. While a sliver of Spanish territory remained under French control and the war itself went on for a few more months, it was the Battle of Vitoria that marked the end of Napoleon's rule on the Iberian Peninsula, as symbolised by the departure from Spain of Joseph Bonaparte, the monarch who had been imposed five years earlier to remove the Bourbons from the Spanish throne.

Journal of the British expedition from Detroit to Vincennes and its defeat by George Rogers Clark : manuscript, 1778-1782

Account of the British forces' expedition which captured Vincennes, Indiana in Dec. 1778, with an account of their eventual defeat in 1779 at the Battle of Vincennes by the American Revolutionary forces led by Col. George Rogers Clark.

Venezuela's Movimiento al Socialismo : from guerrilla defeat to innovative politics /

Includes index.

The defeat of home rule in Salt Lake City.

Mode of access: Internet.

Germany in defeat; a strategic history of the war. First [-fourth] phase.

Vol. 1: 3d ed.

Defeat in the west;

Bibliography: p. 321. Bibliographical references in "Notes" (p. 322-330)

History of England from the fall of Wolsey to the defeat of the Spanish Armada.

Mode of access: Internet.

History of England from the fall of Wolsey to the defeat of the Spanish Armada.

Silver library.

Captive Cathay; an historical poem narrating the resistance of China to the opium trade and her sad defeat: 1775-1860.

Mode of access: Internet.

The history of Mademoiselle de St. Phale; giving a full account of the miraculous conversion of a noble French lady and her daughter to the reform'd religion, with the defeat of the intrigues of a Jesuit, their confessor ...

Tr. by B. Star. cf. British Museum cat.