Great masters,

Plates accompanied by guard sheets with descriptive letterpress.

Albert Dürer et ses dessins /

Mode of access: Internet.

Ausst. 210 - HIerinen sind begriffen vier bücher von menschlicher Proportion durch Albrechten Dürer von Nürenberg erfunden vnd beschriben zu nutz allen denen so zu diser kunst lieb tragen

Vorbesitzer: Heinrich Anton Cornill-d'Orville (Exlibris im Vorderdeckel)

Simson zerreißt den Löwen [Illustration]

Albrecht Dürer

Adam und Eva [Illustration] : Kupferstich

Albrecht Dürer

Simson zerreist den Löwen [Illustration]

Albrecht Dürer

[Fackeltanz in Augsburg]

Bibliogr. Nachweis: Strauss: Woodcuts and wood blocks of A. Dürer, Nr. 186

Ausst. 209 - UNderweysung der messung mit dem zirckel vn[d] richtscheyt in Linien ebnen vnnd gantzen corporen

Vorbesitzer: Heinrich Anton Cornill-d'Orville (Exlibris auf fol. Iv)

Albrecht Dürer: [Rezension]

Theodor Harburger

A consensus genetic map of sorghum that integrates multiple component maps and high-throughput Diversity Array Technology (DArT) markers

Background: Sorghum genome mapping based on DNA markers began in the early 1990s and numerous genetic linkage maps of sorghum have been published in the last decade, based initially on RFLP markers with more recent maps including AFLPs and SSRs and very recently, Diversity Array Technology (DArT) markers. It is essential to integrate the rapidly growing body of genetic linkage data produced through DArT with the multiple genetic linkage maps for sorghum generated through other marker technologies. Here, we report on the colinearity of six independent sorghum component maps and on the integration of these component maps into a single reference resource that contains commonly utilized SSRs, AFLPs, and high-throughput DArT markers. Results: The six component maps were constructed using the MultiPoint software. The lengths of the resulting maps varied between 910 and 1528 cM. The order of the 498 markers that segregated in more than one population was highly consistent between the six individual mapping data sets. The framework consensus map was constructed using a "Neighbours" approach and contained 251 integrated bridge markers on the 10 sorghum chromosomes spanning 1355.4 cM with an average density of one marker every 5.4 cM, and were used for the projection of the remaining markers. In total, the sorghum consensus map consisted of a total of 1997 markers mapped to 2029 unique loci ( 1190 DArT loci and 839 other loci) spanning 1603.5 cM and with an average marker density of 1 marker/0.79 cM. In addition, 35 multicopy markers were identified. On average, each chromosome on the consensus map contained 203 markers of which 58.6% were DArT markers. Non-random patterns of DNA marker distribution were observed, with some clear marker-dense regions and some marker-rare regions. Conclusion: The final consensus map has allowed us to map a larger number of markers than possible in any individual map, to obtain a more complete coverage of the sorghum genome and to fill a number of gaps on individual maps. In addition to overall general consistency of marker order across individual component maps, good agreement in overall distances between common marker pairs across the component maps used in this study was determined, using a difference ratio calculation. The obtained consensus map can be used as a reference resource for genetic studies in different genetic backgrounds, in addition to providing a framework for transferring genetic information between different marker technologies and for integrating DArT markers with other genomic resources. DArT markers represent an affordable, high throughput marker system with great utility in molecular breeding programs, especially in crops such as sorghum where SNP arrays are not publicly available.

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R(2) approximately 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for approximately 2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.

Carta enviada por Hans y Elsabeth Albrecht a Justo Garate en 1966

1 carta (mecanografiada) ; 210x297mm. Ubicación: Caja 1 - Carpeta 17

La capilla del Cristo de las Descalzas Reales de Madrid: arte y liturgia en el siglo XVI

Estudio de la capilla del Cristo de las Descalzas Reales de Madrid que analiza la historia de la obra, sus aspectos artísticos y su significado. Las circunstancias de la fundación del monasterio explican la función de la capilla como escenario de las especiales ceremonias litúrgicas del Viernes Santo y del Domingo de Resurrección instauradas en razón de su origen, lo que permite asimismo fijar su ejecución entre las obras de su etapa fundacional, probablemente entre 1560 y 1565, diseñada por artistas de los talleres reales. Se aporta noticia documental sobre Diego de Urbina y Juan de Cerecedo como pintores al servicio de Juana de Austria en ese momento.