El sutil universo de las formas : homenaje a Eliana Molinelli

Fil: Benchimol, Silvia. Universidad Nacional de Cuyo. Facultad de Artes y Diseño

Idea Eliana pro triplici statu prophetae visibilis inter homines ante raptum, occulti post eundem in Synagoga & Ecclesia, iterumque visibilis in fine mundi /

Mode of access: Internet.

The Eliana Rivero Research Scholarship in Cuban Studies- Call for Applications from Graduate Students

This flyer promotes a call for applications from Graduate Students for the Eliana Rivero Research Scholarship in Cuban Studies. The scholarship provides one graduate student the opportunity to conduct research in Cuban studies- with special emphasis in the humanities- at the Cuban Research Institute. The deadline for applications is February 15, 2016.

Clusterin facilitates COMMD1 and I-kB degradation to enhance NF-kB activity in prostate cancer cells

Secretory clusterin (sCLU) is a stress-activated, cytoprotective chaperone that confers broad-spectrum cancer treatment resistance, and its targeted inhibitor (OGX-011) is currently in phase II trials for prostate, lung, and breast cancer. However, the molecular mechanisms by which sCLU inhibits treatment-induced apoptosis in prostate cancer remain incompletely defined. We report that sCLU increases NF-κB nuclear translocation and transcriptional activity by serving as a ubiquitin-binding protein that enhances COMMD1 and I-κB proteasomal degradation by interacting with members of the SCF-βTrCP E3 ligase family. Knockdown of sCLU in prostate cancer cells stabilizes COMMD1 and I-κB, thereby sequestrating NF-κB in the cytoplasm and decreasing NF-κB transcriptional activity. Comparative microarray profiling of sCLU-overexpressing and sCLU-knockdown prostate cancer cells confirmed that the expression of many NF-κB–regulated genes positively correlates with sCLU levels. We propose that elevated levels of sCLU promote prostate cancer cell survival by facilitating degradation of COMMD1 and I-κB, thereby activating the canonical NF-κB pathway.