Modulation of the chaperone-like activity of bovine α-crystallin

The effects of pantethine, glutathione, and selected chemical reagents on the anti-aggregation activity of α-crystallin was evaluated. Protein aggregation was monitored by light scattering of solutions of denatured βL-crystallin or alcohol dehydrogenase (ADH). The ratios of βL-crystallin/α-crystallin and ADH/α-crystallin were adjusted so that partial inhibition of protein aggregation at 60°C or 37°C, respectively, was observed and modulation of the chaperone action of α-crystallin could be evaluated easily with selected endogenous metabolites. Enhancement of the anti-aggregation activity in the βL-crystallin assay was strongest with pantethine, which appeared to interact with α-crystallin. Enhancement of the anti-aggregation activity in the ADH assay was strongest with glutathione which appeared to interact with ADH. The results indicated that the products of common metabolic pathways can modulate the chaperone-like effects of α-crystallin on protein aggregation.

Report of the proceedings of the general court martial held at the King's Arms Tavern in Albany, April 4, 1776

Contains summaries of court-martials of a variety of soldiers for desertion, drunk and disorderly conduct, striking an officer, and damning the American congress.

1982 University of Michigan Men's Golf Team

Front Row: Ken Clark, John Nolan, Dan Roberts, Jim Becker, Ryan Wiezycki.

Back Row: coach Tom Simon, Jim Yaffee, Steve Maddelena, Ed Humenik, Ed Frutig, assistant coach Jim Carras.

The care of books : an essay on the development of libraries and their fittings, from the earliest times to the end of the eighteenth century /

Includes bibliographical references.

A Concise Anglo-Saxon dictionary : for the use of students /

Photocopy.

"Ohio and Pennsylvania Rail-Road," (to connect Pittsburg with the great west.) : report to the president and directors of the Ohio and Pennsylvania Rail-Road Company /

Mode of access: Internet.

The care of books:

Mode of access: Internet.

Observations on fevers : especially those of the continued type and on the scarlet fever attended with ulcerated sore-throat /

Mode of access: Internet.

Modern mathematics : seventh-[eighth] year /

"Scale, protractor and square" in pocket on end lining-paper of each volume.

Mathematics in life,

A. Measurement.--B. Constructions.--C. Drawing to scale.--D. Percents.--E. Uses of graphs.--F. Formulas & Equations. --G. Wise use of money.

Reports of cases argued and determined in the courts of Exchequer & Exchequer Chamber, from Easter term, II Geo. IV. to [Trinity term, 2 Will. IV.] ... both inclusive [1830-1832],

Mode of access: Internet.

Reports of cases argued and determined in the courts of Exchequer and Exchequer chamber, from Hiliary term, 6 Will. IV, to [Easter term, 10 Vict.]...both inclusive. [1836-1847] With tables of the cases and principal matters.

Vol. 1. 1847: v. 2-4,6-8,13-14, 1846: v. 5,9,11-12, 1852: v. 10, 1845: v. 15, 1848: v. 16, 1849.

Gleanings by the way;

Sketches of travel in various parts of the United States, with an account of the Mormons, which was originally published in part in the Episcopal recorder, in 1840.

Observations on the diseases in long voyages to hot countries : and particularly on those which prevail in the East Indies /

Mode of access: Internet.