Prognostic Implication of Lymphovascular Invasion Detected by Double Immunostaining for D2-40 and MITF1 in Primary Cutaneous Melanoma.

BACKGROUND Lymphovascular invasion (LVI) is associated with adverse outcomes in primary cutaneous melanoma (PCM). Detection of LVI by hematoxylin and eosin staining alone is 0%-6%, but targeting lymphovascular structures increases the detection rate. OBJECTIVE To examine the prognostic significance of LVI detected by immunostaining for D2-40 and microphthalmia-associated transcription factor 1 (MITF1) in PCM. METHODS The authors retrospectively analyzed 120 PCM samples. We compared the LVI detection rates of immunostaining for D2-40 only (22%), double staining for D2-40 and MITF1 (38%), and hematoxylin and eosin, and examined the association of LVI with clinicopathologic variables and clinical outcomes. RESULTS Immunolabeling with both methods significantly increased the LVI detection rate. Double staining for D2-40 and MITF1 as well as D2-40-detected LVI was significantly associated with increased Breslow thickness, number of mitoses, and sentinel lymph node (SLN) metastasis. D2-40-detected LVI was also associated with ulceration. Although the difference was not significant, double staining for D2-40 and MITF1 allowed for easier detection of LVI than D2-40 alone. LIMITATIONS This study was conducted in a tertiary referral institution; therefore, a referral bias cannot be excluded. CONCLUSIONS Immunolabeling increased detection of LVI in PCM. Because LVI is a positive predictive marker for SLN metastasis, the authors propose using anti-D2-40 and anti-MITF1 in the evaluation of LVI in patients with PCM with a certain risk of SLN metastasis.

Rabbinical manuscripts of Judah Monis, ca. 1700s

This leather-bound volume contains ten handwritten Hebrew texts presumably compiled by Judah Monis in the early 18th century. The pieces range from three to 150 pages on different sized leaves and appear to be in multiple hands. The last page of the volume has the struck-through inscription, "Judah Monis' Book" and accompanies a 44-page text. The texts are unattributed and undated, but have been identified as transcriptions of cabalistic writings and include a short biography of Isaac Luria (1533-1572) and extracts from the work of Luria, Hayyim ben Joseph Vital, Jacob ben Hayyim Zemah, Abraham ben Isaac of Granada, and Naphtali Bachrach. The transcriptions appear to be unattributed and undated.

The most holy trinosophia of the Comte de Saint-Germain,

Initials.

Sefer Shaʻar ha-yiḥudim ; ṿe-Sefer Tsadiḳ yesod ʻolam : mayim ḳedoshim mi-peleg Eloḳim /

Reprint, with new introduction. Originally published: Lemberg : Leib Rappaport, 1855.

Sefer Yetsirah = Sepher Yezirah : a book on creation; or the Jewish metaphysics of remote antiquity /

Bound with : A sketch of the Talmud : the world renowned collection of Jewish traditions / by Isidor Kalisch. New York : L. H. Frank, 1877.

Ḥoshev maḥashavot.

Mode of access: Internet.

Sefer Meʻarat śedeh ha-makhpelah : shir ḥadash /

Mode of access: Internet.

Sefer Ḥesed le-Avraham ... /

Mode of access: Internet.

Divre Shalom, ʻal divre ha-ARI ... ube-sofo derushim.

Mode of access: Internet.

Sefer Tsiyoni = Zijoni : perush ʻal ha-Torah ʻal derekh ha-emet /

With: Najar, Judah ben Jacob. Sefer Limude H. Lemberg : Druck Verlag des U.W. Salat, 1881.

Sefer Merkavah shelemah : kolel Baraitot

Mode of access: Internet.

Sefer Ḥayim le-gufa : ...ʻal otiyot ha-torah.

Mode of access: Internet.

Der Sohar und seine Lehre : Einleitung in die Gedankenwelt der Kabbalah /

Mode of access: Internet.

Zekhirah le-hayim ...

Mode of access: Internet.

La kabbale : ou, La philosophie religieuse des Hébreux /

Includes bibliographical references.