Whole-genome linkage analysis of rheumatoid arthritis susceptibility loci in 252 affected sibling pairs in the United Kingdom

Objective. To undertake a systematic wholegenome screen to identify regions exhibiting genetic linkage to rheumatoid arthritis (RA). Methods. Two hundred fifty-two RA-affected sibling pairs from 182 UK families were genotyped using 365 highly informative microsatellite markers. Microsatellite genotyping was performed using fluorescent polymerase chain reaction primers and semiautomated DNA sequencing technology. Linkage analysis was undertaken using MAPMAKER/SIBS for single-point and multipoint analysis. Results. Significant linkage (maximum logarithm of odds score 4.7 [P = 0.000003] at marker D6S276, 1 cM from HLA-DRB1) was identified around the major histocompatibility complex (MHC) region on chromosome 6. Suggestive linkage (P < 7.4 × 10-4) was identified on chromosome 6q by single- and multipoint analysis. Ten other sites of nominal linkage (P < 0.05) were identified on chromosomes 3p, 4q, 7p, 2 regions of 10q, 2 regions of 14q, 16p, 21q, and Xq by single-point analysis and on 3 sites (1q, 14q, and 14q) by multipoint analysis. Conclusion. Linkage to the MHC region was confirmed. Eleven non-HLA regions demonstrated evidence of suggestive or nominal linkage, but none reached the genome-wide threshold for significant linkage (P = 2.2 × 10-5). Results of previous genome screens have suggested that 6 of these regions may be involved in RA susceptibility.

Efecto de diferentes densidades de siembra sobre el crecimiento y rendimiento del cultivo de chía (Salvia hispánica L.) Sébaco, Matagalpa, 2015

Este trabajo se realizó con la finalidad de d eterminar la influencia de diferentes densidades de siembra (10, 20, 30 y 40 plantas/m) , sobre el crecimiento, desarrollo y rendimiento de l cultivo de chía ( Salvia hispánica L.) ; se efectuó análisis económico a través de cálculo de costos de producción para determinar la rentabilidad de los tratamientos . Se estableció en el periodo de septiembre 2014 a febrero 2015, en la finca Tamarindo de Oro, de la ciudad de Sébaco, Matagalpa, ubicado a 1 02 km al N orte de Managua. Se utilizó un diseño experimental uní - factorial en arreglos de b loques completos al azar, con 4 tratamientos y 6 repeticiones. Las variables evaluadas fueron, altura de planta, diámetro de tallo, número de ramas primarias y secundarias, número de espigas y r endimiento a la cosecha, presentando en todas ellas diferencia estadística significativa , a excepción de la variable de rendimiento . Para la variable altura de planta, en la densidad más alta (40 plantas/m) , se obtuvo la m ayor altura con un promedio de 1.24 metros. La densidad más baja (10 plantas/m), fue la que logró los mejores resultado en las variables diámetro ( 0.83 mm ) , ramas primarias ( 12 unidad ) , secundarias (15 unidad ) , espigas ( 27 unidad ) y rendimiento (826.46 kg/ha) . El análisis económico demuestra una relación beneficio costos mayor de 1 esto quiere decir que todos los tratamiento s presenta ron una rentabilidad viable, donde el tratamiento a 1 de 10 plantas/m, es mayor en relación a los demás

Diário da Constituinte [gravação de vídeo] : [programa n. 252]

Continua a votação do substitutivo na Comissão de Sistematização da Assembleia Nacional Constituinte (ANC). Aprovado o acesso dos cidadãos aos bancos de dados públicos. O Deputado José Genoíno (PT-SP) apresentou destaque para que também haja acesso aos órgãos de segurança. Aprovado o destaque apresentado pelo Deputado Nelson Jobim (PMDB-RS) que prevê que as informações públicas requeridas pelo cidadão serão prestadas no prazo da lei. Esse destaque foi extraído de uma emenda popular. Aprovado destaque do Deputado Jovanni Masini (PMDB-PR) que concede asilo político aos indivíduos que sofrem perseguição em razão de raça, de nacionalidade ou de convicção política. Aprovado também a parte do texto que dispõe sobre a extradição de brasileiro naturalizado envolvido comprovadamente com o tráfico de drogas. O Deputado Francisco Rossi (PTB-SP) declara que essa emenda fere fundo o tráfico internacional de drogas. Deve ser prorrogado o prazo para a conclusão da votação na Comissão de Sistematização. O Relator Bernardo Cabral (PMDB-AM) considera que o mais conveniente seria não estabelecer prazos, mas sim ver o desenvolvimento dos trabalhos. Afirmou também que a decisão sobre a prorrogação, de acordo com o regimento interno, é da Mesa da Assembleia Nacional Constituinte. Membros da União dos Jovens Socialistas (UJS) estão mantendo plantão em Brasília. Eles querem o serviço militar facultativo e o voto a partir dos dezesseis (16) anos. O Coordenador da UJS Apolinário Rebelo declara que 55% dos jovens entre 16 e 18 anos já trabalham e, por isso, devem ter também o direito de votar. A bancada jovem da Constituinte apoia a iniciativa. O Deputado Expedito Júnior (PMDB-RO) crê na aprovação da proposta na Comissão de Sistematização.

Population dynamic and stock assessment of lobster resources of Cha-bahar region (with particular ref. to Panulirus homarus)

Amoungst the three spiny lobster species in southern Iranian waters, Panulirus homarus is the only commercial species with a total landings of 20-45 tons per year indicating a decrease in both landings and CPIJE in recent years. Fishing has been regulated according to the no. of fisherman and effort, and trap ha's replaced the gillnef since 1994. Fishing is carried out along the rocky shores of Chah-Bahar region through different landing places by local fisherman for a period of about two months. Most of catch is exported mainly frozen. This research was sposored by the Fisheries Research Dept. and aimed to work on the population dynamics and stock assessment in order to stablish a better understandings of the stock and hence a proper management in this region. Sampling was done for. 10 successive months in _5 major landing places from 1994 to 1995 with no sampling during the monsoon period through June to July. Althogethere, 8500 specimen were collected and the biometry was done accordings to the sex, region and month. Average total length, total weight and carapace length was obtained 216mm., 452 gr. and 75mm. respectively. Total length-weight relationship of both sexes was calculated and follows the cubic law. Regression coefficients for both sexes was 2.8231, males 2.9616, total females 2.7490, berried females 2.6611- and non-berried females

(Ga,Mn,N) compounds growth with mass-analyzed low energy dual ion beam deposition

The (Ga,Mn,N) samples were grown by the implantation of low-energy Mn ions into GaN/Al2O3 substrate at different elevated substrate temperatures with mass-analyzed low-energy dual ion beam deposition system. Auger electron spectroscopy depth profile of samples grown at different substrate temperatures indicates that the Mn ions reach deeper in samples with higher substrate temperatures. Clear X-ray diffraction peak from (Ga,Mn)N is observed in samples grown at the higher substrate temperature. It indicates that under optimized substrate temperature and annealing conditions the solid solution (Ga,Mn)N phase in samples was formed with the same lattice structure as GaN and different lattice constant. (C) 2003 Elsevier Science B.V. All rights reserved.

Compte rendu: Romain Colonna (dir.), (2015), Des paroles, des langues et des pouvoirs, Paris, L’Harmattan, coll. « Espaces discursifs », 252 p. [ISBN : 978-2-343-04951-9]

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新刻京本全像插增田虎王慶忠義水滸全傳Xin ke jing ben quan xiang cha zeng tian hu wang qing zhong yi shui hu quan zhuan.Le Shui hu zhuan, etc., édition complétée et illustrée, nouvellement gravée à la capitale.

Vieille édition avec illustrations en haut des pages.Livre 20 et début du livre 21 (hui 99 à 102).

Balance de las finanzas de los municipios de: Soacha,Fusagasugá,Chía,Zipaquirá en el 2008

Gestión del Conocimiento

Balance de las finanzas de los municipios de Soacha, Fusagasugá, Zipaquirá, Chía : 2008

Gestión del conocimiento