A key to the bats of the Philippine Islands / Nina R. Ingle, Lawrence R. Heaney.

n.s. no.69(1992)

Systematic identification of genomic markers of drug sensitivity in cancer cells.

Clinical responses to anticancer therapies are often restricted to a subset of patients. In some cases, mutated cancer genes are potent biomarkers for responses to targeted agents. Here, to uncover new biomarkers of sensitivity and resistance to cancer therapeutics, we screened a panel of several hundred cancer cell lines--which represent much of the tissue-type and genetic diversity of human cancers--with 130 drugs under clinical and preclinical investigation. In aggregate, we found that mutated cancer genes were associated with cellular response to most currently available cancer drugs. Classic oncogene addiction paradigms were modified by additional tissue-specific or expression biomarkers, and some frequently mutated genes were associated with sensitivity to a broad range of therapeutic agents. Unexpected relationships were revealed, including the marked sensitivity of Ewing's sarcoma cells harbouring the EWS (also known as EWSR1)-FLI1 gene translocation to poly(ADP-ribose) polymerase (PARP) inhibitors. By linking drug activity to the functional complexity of cancer genomes, systematic pharmacogenomic profiling in cancer cell lines provides a powerful biomarker discovery platform to guide rational cancer therapeutic strategies.

4-7-19, stade Pershing, [Lawrence] Shields, Américain, à l'arrivée de la course de relais de 3000 m [des Jeux interalliés, le n°835 William C. Gray, membre du relais américain, lève le poing en signe de victoire] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54716

Butler County, June 30, 2002

County Audit Report

Butler County Solid Waste Commission, June 30, 2001 & June 30, 2002

Other Audit Reports

Butler County Solid Waste Commission, June 30, 2002 & June 30, 2003

Other Audit Reports

Butler County, June 30, 2003

County Audit Report

Butler County Solid Waste Commission, Independent Auditor's Reports, Financial Statement, Schedule of Findings, June 30, 2004

Other Audit Reports - Butler County Solid Waste Commission

Butler County, Independent Auditor's Reports, Basic Financial Statements and Supplementary Information, Schedule Findings, June 30, 2004

County Audit Report

Butler 2004 Annual County Profile, 2004

County Profile

Butler County, Independent Auditor's Reports, Basic Financial Statements and Supplementary Information, Schedule of Findings, June 30, 2005

County Audit Report

Butler County Solid Waste Commission, Independent Auditor's Reports, Financial Statement and Required Supplementary Information, Schedule of Findings, June 30, 2005

Other Audit Reports - 28E Organizations

Butler County, Independent Auditor's Reports, Basic Financial Statements and Supplementary Information, Schedule of Findings, June 30, 2006

County Audit Report