Memoires pour servir a l'histoire de France et de Bourgogne : contenant un journal de Paris, sous les regnes de Charles VI. & de Charles VII., l'histoire du Meurtre de Jean sans peur, Duc de Bourgogne, avec les preuves; les tats des maisons & officiers des ducs de Bourgogne de la derniere race, enrichis de notes historiques très-interessantes pour un grand nombre de familles illustres Des lettres de Charles le Hardy, Duc de Bourgogne, au Sieur de Neuschastel du 'Fay, ... [Title continues in note]

Title continued: ... gouverneur du Luxembourg; & plusieurs autres monumens très-utiles pour l'éclaircissement de l'histoire du XIV. & XV. siecle. Avec une table des matieres, & des noms des familles les plus considerables dont il est fait mention dans l'ouvrage.

Histoire des ducs de Bourgogne de la maison de Valois, 1364-1477,

Mode of access: Internet.

Si hay moreras hay cristianos nuevos: Los Duques de Pastrana y la industria de la seda en la formación de un espacio de conflicto (Pastrana, c. 1569- c. 1609)

Durante las últimas décadas del siglo XVI los moriscos, amparados por el poder ducal, acapararon la producción y comercio de la seda de la villa de Pastrana, así como adquirieron cada vez mayores cotas de poder municipal. En este artículo se analiza la constitución en la villa ducal de Pastrana de un espacio de odio a causa de la competencia social entre cristianos viejos y moriscos. Este odio se tradujo en una caracterización de los moriscos, sobre todo a partir de 1572, como cristianos nuevos sospechosos. Esta experiencia estigmatizadora sería un precedente de lo que ocurriría en las primeras decadas del siglo XVII con los mercaderes portugueses que sustituyeron en el negocio de la seda a los moriscos tras su expulsión. Entonces se contruiría la imagen del portugués critptojudío.

Los judeoconversos y los Duques de Medina Sidonia (1471-1555). Estado de la cuestión y líneas de trabajo

En este artículo planteamos, en primer lugar, una revisión de lo que hasta la fecha sabemos sobre la relación entre la casa ducal de Medina Sidonia y los conversos en un periodo crucial para la historia de esta minoría. En segundo lugar, a partir del cruce de la información aportada por las crónicas del siglo XV con las últimas aportaciones historiográficas sobre la cuestión, vamos a tratar de arrojar algo de luz tanto sobre los ritmos temporales de esa aproximación como sobre el nivel de integración de tal minoría en el ámbito señorial, para terminar señalando algunas hipótesis y líneas de trabajo de futuro sobre esta cuestión.

Diritto tradizionale nobiliare e "diritto internazionale" nel pensiero di Giovanni Giacomo Leonardi. Con l'edizione dei manoscritti de' "Il Principe Cavalliero in duello", "Il Cavalliero Ambasciatore" e dei "Pareri in materia di honore di Cavalleria pertinenti al duello"

La presente ricerca prende avvio dalla ricostruzione della biografia di Giovanni Giacomo Leonardi (1498-1562), pesarese, architetto militare, ambasciatore e cavaliere al servizio dei duchi d’Urbino Francesco Maria I (1490-1538) e Guidobaldo II (1514-1574) della Rovere. Attraverso lo spoglio delle fonti tra Pesaro, Firenze e Venezia, se ne è fornita una collocazione nel panorama politico-culturale dell’Italia cinquecentesca, al fine di evidenziare l’importanza del suo trattato in trentadue libri, intitolato "Il Principe Cavalliero", dedicato ai precetti dell’arte militare, diplomatica e cavalleresca necessari a formare il perfetto principe del tardo Rinascimento. Dell’opera, rimasta inedita, sono state trascritte e studiate le parti dedicate alla scienza dell’onore e all’arte dell’ambasceria, al fine di dimostrare come i dettami della ‘religione di cavalleria’ influenzassero ogni ambito delle relazioni tra gentiluomini, comprese quelle interstatuali.

Dukes and poets in Ferrata : a study in the poetry, religion and politics of the fifteenth and early sixteenth centuries /

Mode of access: Internet.

Account of the expenses of John of Brabant and Thomas and Henry of Lancaster, A.D. 1292-3.

Forms part of the Society's Publication no. LV

Strange histories, of kings, princes, dukes, earles, lords, ladies, knights and gentlemen ...

Later published with title: The royal garland of delight.

Plays of Mr. William Shakespeare : as re-written or re-arranged by his successors of the restoration period as presented at the Dukes theatre and elsewhere circa 1664-1669; being the text of these so-restored plays with the First folio Shakespeare text, with critical introductions /

Edition of 250 sets. This set no. . Arbitrarily numbered to correspond with the set of the Bankside Shakespeare.

The royal dukes and princesses of the family of George III. A view of court life and manners for seventy years, 1760-1830.

Mode of access: Internet.

Surface thermal analysis of North Brabant cities and neighbourhoods during heat waves

The urban heat island effect is often associated with large metropolises. However, in the Netherlands even small cities will be affected by the phenomenon in the future (Hove et al., 2011), due to the dispersed or mosaic urbanisation patterns in particularly the southern part of the country: the province of North Brabant. This study analyses the average night time land surface temperature (LST) of 21 North-Brabant urban areas through 22 satellite images retrieved by Modis 11A1 during the 2006 heat wave and uses Landsat 5 Thematic Mapper to map albedo and normalized difference temperature index (NDVI) values. Albedo, NDVI and imperviousness are found to play the most relevant role in the increase of nighttime LST. The surface cover cluster analysis of these three parameters reveals that the 12 “urban living environment” categories used in the region of North Brabant can actually be reduced to 7 categories, which simplifies the design guidelines to improve the surface thermal behaviour of the different neighbourhoods thus reducing the Urban Heat Island (UHI) effect in existing medium size cities and future developments adjacent to those cities.

Clinicopathological significance of the 'keloid-like' collagen and myxoid stroma in advanced rectal cancer

Aim: To establish the histological categorization of fibrotic stroma which reflects the biological behaviour of advanced rectal cancer. Methods and results: Six hundred and twenty-seven surgically resected cases of advanced rectal carcinoma were examined. We histologically categorized fibrotic stroma in the invasive frontal region into three groups: type A, multiple fine and mature fibres were stratified into layers: type B, broad bands of eosinophilic hyalinized collagen ('keloid-like' collagen) were intermingled: type C, myxoid stroma. Type A stroma was observed in 63% of patients, type B stroma in 25%, type C stroma in 12%.. The incidence of type A stroma decreased in accordance with Dukes stage (98% in Dukes A: 73% in B: 41%, in C1: 29% in C2) and conversely, there was an increase of C type (0%, in Dukes A; 4%, in B: 20% in C1: 54% in C2). Stroma type had a significant correlation with long-term survival (80% of 5-year survival in type A stroma: 54% in type B: 26% in type C). Based on multivariate analysis. it was found that the stromal pattern had independent prognostic value, together with nodal involvement. growth pattern. and lymphocyte infiltration. Conclusions: Tumour fibrotic stroma may play an important role as a regulator of neoplastic behaviour. Pathological categorization of the fibrotic stroma is helpful for predicting the prognostic outcome of patients with rectal carcinoma.

Dukes B colorectal cancer: distinct genetic categories and clinical outcome based on proximal or distal tumor location.

PURPOSE: The aim of this study was to determine whether tumor location proximal or distal to the splenic flexure is associated with distinct molecular patterns and can predict clinical outcome in a homogeneous group of patients with Dukes B (T3-T4, N0, M0) colorectal cancer. It has been hypothesized that proximal and distal colorectal cancer may arise through different pathogenetic mechanisms. Although p53 and Ki-ras gene mutations occur frequently in distal tumors, another form of genomic instability associated with defective DNA mismatch repair has been predominantly identified in the proximal colon. To date, however, the clinical usefulness of these molecular characteristics remains unproven. METHODS: A total of 126 patients with a lymph node-negative sporadic colon or rectum adenocarcinoma were prospectively assessed with the endpoint of death by cancer. No patient received either radiotherapy or chemotherapy. p53 protein was studied by immunohistochemistry using DO-7 monoclonal antibody, and p53 and Ki-ras gene mutations were detected by single strand conformation polymorphism assay. RESULTS: During a mean follow-up of 67 months, the overall five-year survival was 70 percent. Nuclear p53 staining was found in 57 tumors (47 percent), and was more frequent in distal than in proximal tumors (55 vs. 21 percent; chi-squared test, P < 0.001). For the whole group, p53 protein expression correlated with poor survival in univariate and multivariate analysis (log-rank test, P = 0.01; hazard ratio = 2.16; 95 percent confidence interval = 1.12-4.11, P = 0.02). Distal colon tumors and rectal tumors exhibited similar molecular patterns and showed no difference in clinical outcome. In comparison with distal colorectal cancer, proximal tumors were found to be statistically significantly different on the following factors: mucinous content (P = 0.008), degree of histologic differentiation (P = 0.012), p53 protein expression, and gene mutation (P = 0.001 and 0.01 respectively). Finally, patients with proximal tumors had a marginally better survival than those with distal colon or rectal cancers (log-rank test, P = 0.045). CONCLUSION: In this series of Dukes B colorectal cancers, p53 protein expression was an independent factor for survival, which also correlated with tumor location. Eighty-six percent of p53-positive tumors were located in the distal colon and rectum. Distal colon and rectum tumors had similar molecular and clinical characteristics. In contrast, proximal neoplasms seem to represent a distinct entity, with specific histopathologic characteristics, molecular patterns, and clinical outcome. Location of the neoplasm in reference to the splenic flexure should be considered before group stratification in future trials of adjuvant chemotherapy in patients with Dukes B tumors.

Factor structure of the SOCRATES questionnaire in hospitalized medical patients.

The Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES), a 19-item instrument developed to assess readiness to change alcohol use among individuals presenting for specialized alcohol treatment, has been used in various populations and settings. Its factor structure and concurrent validity has been described for specialized alcohol treatment settings and primary care. The purpose of this study was to determine the factor structure and concurrent validity of the SOCRATES among medical inpatients with unhealthy alcohol use not seeking help for specialized alcohol treatment. The subjects were 337 medical inpatients with unhealthy alcohol use, identified during their hospital stay. Most of them had alcohol dependence (76%). We performed an Alpha Factor Analysis (AFA) and Principal Component Analysis (PCA) of the 19 SOCRATES items, and forced 3 factors and 2 components, in order to replicate findings from Miller and Tonigan (Miller, W. R., & Tonigan, J. S., (1996). Assessing drinkers' motivations for change: The Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES). Psychology of Addictive Behavior, 10, 81-89.) and Maisto et al. (Maisto, S. A., Conigliaro, J., McNeil, M., Kraemer, K., O'Connor, M., & Kelley, M. E., (1999). Factor structure of the SOCRATES in a sample of primary care patients. Addictive Behavior, 24(6), 879-892.). Our analysis supported the view that the 2 component solution proposed by Maisto et al. (Maisto, S.A., Conigliaro, J., McNeil, M., Kraemer, K., O'Connor, M., & Kelley, M.E., (1999). Factor structure of the SOCRATES in a sample of primary care patients. Addictive Behavior, 24(6), 879-892.) is more appropriate for our data than the 3 factor solution proposed by Miller and Tonigan (Miller, W. R., & Tonigan, J. S., (1996). Assessing drinkers' motivations for change: The Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES). Psychology of Addictive Behavior, 10, 81-89.). The first component measured Perception of Problems and was more strongly correlated with severity of alcohol-related consequences, presence of alcohol dependence, and alcohol consumption levels (average number of drinks per day and total number of binge drinking days over the past 30 days) compared to the second component measuring Taking Action. Our findings support the view that the SOCRATES is comprised of two important readiness constructs in general medical patients identified by screening.

Detection of recurrence of large-bowel carcinoma by radioimmunoassay of circulating carcinoembryonic antigen (C.E.A.).

The usefulness and limitations of the carcinoembryonic antigen (C.E.A.) radioimmunoassay for the evaluation of tumour resection and for the detection of tumour relapse were studied in patients with large-bowel carcinoma. The level of plasma-C.E.A. was determined before any treatment in a group of 101 patients with histologically proven adenocarcinoma of the colon and rectum. 71% of all patients and 63% of cases with localised tumour (Dukes A and B) had a preoperative C.E.A. value of 5 ng. per ml. or higher. This limit was reached by only 1 of 90 apparently healthy, non-smoking blood-donors. Among 45 patients for whom a complete tumour resection was reported, all patients except 5 showed a drop of C.E.A. to normal values after surgery. The 5 patients whose C.E.A. did not fall to below 5 ng. per ml. showed a subsequent rise in C.E.A. level and were all found later to have a tumour relapse. The results indicate that an incomplete drop of circulating C.E.A. level one month after surgery has a bad prognostic significance. 22 of these patients were followed up by repeated C.E.A. radioimmunoassay for several months after surgery. 8 showed a progressive increase in C.E.A. levels preceding clinical diagnosis of tumour relapse by two to ten months. 6 other patients showed a moderate increase in C.E.A. levels, suggesting a tumour relapse not yet clinically detectable. The remaining 8 patients showed no increase in C.E.A. level above 5 ng. per ml. and no clinical symptoms of relapse. The results demonstrate that relapses of colon and rectum carcinoma can be detected by increased C.E.A. levels months before the appearance of any clinical evidence.