Mapping the diagnosis axis of an interface terminology to the NANDA International Taxonomy

Background: Nursing terminologies are designed to support nursing practice but, as with any other clinical tool, they should be evaluated. Cross-mapping is a formal method for examining the validity of the existing controlled vocabularies. Objectives: The study aims to assess the inclusiveness and expressiveness of the nursing diagnosis axis of a newly implemented interface terminology by cross-mapping with the NANDA-I taxonomy. Design/Methods: The study applied a descriptive design, using a cross-sectional, bidirectional mapping strategy. The sample included 728 concepts from both vocabularies. Concept cross-mapping was carried out to identify one-to-one, negative, and hierarchical connections. The analysis was conducted using descriptive statistics. Results: Agreement of the raters" mapping achieved 97%. More than 60% of the nursing diagnosis concepts in the NANDA-I taxonomy were mapped to concepts in the diagnosis axis of the new interface terminology; 71.1% were reversely mapped. Conclusions: Main results for outcome measures suggest that the diagnosis axis of this interface terminology meets the validity criterion of cross-mapping when mapped from and to the NANDA-I taxonomy.

Sensitive bromatometric assay methods for finasteride in pharmaceuticals

Three sensitive spectrophotometric methods are presented for the determination of finasteride in bulk and in tablets. The methods rely on the use of bromate-bromide reagent and three dyes namely, methyl orange, indigocarmine and thymol blue as reagents. They involve the addition of a measured excess of bromate-bromide reagent to finasteride in acid medium, and after the bromination reaction is judged to be complete, the unreacted bromine is determined by reacting with a fixed amount of either methylorange and measuring the absorbance at 520 nm (method A) or indigocarmine and measuring the absorbance at 610 nm (method B) or thymol blue and measuring the absorbance at 550 nm (method C). In all the methods, the amount of insitu generated bromine reacted corresponds to the amount of finasteride. The absorbance measured at the respective wavelength is found increase linearly with the concentration of finasteride. Beer's law is obeyed in the ranges 0.25- 2.0, 0.5-6.0 and 1-12 µg mL-1 for method A, method B and method C, respectively. The calculated molar absorptivity values are 5.7x10(4), 3.12x10(4) and 1.77x10(4) L mol-1 cm-1 respectively, for method A, method B and method C, and the corresponding Sandell sensitivity values are 0.0065, 0.012 and 0.021 µg cm-2. The limits of detection (LOD) and quantification (LOQ) are also reported for all the methods. Accuracy and, intra-day and inter-day precisions of the methods were established according to the current ICH guidelines. The methods were successfully applied to the determination of finasteride in commercially available tablets and the results were found to closely agree with the label claim. The results of the methods were statistically compared with those of a reference method by applying Student's t-test and F-test. The accuracy and reliability of the methods were further confirmed by performing recovery tests via standard addition procedure.

Highly sensitive spectrophotometric methods for the determination of olanzapine

Highly sensitive and selective spectrophotometric methods (A and B) were developed for the determination of micro amounts of olanzapine (OLZ). Method A (direct method) is based on the oxidation of olanzapine with a known excess of iodine monochloride (ICl) in an acidic medium. Under the same condition, thymol blue was iodinated by unreacted ICl, and the absorbance of uniodinated thymol blue was measured at 536 nm. The decrease in ICl concentration is a measure of drug concentration. In method B (indirect method), oxidation of OLZ by a known excess of Ce(IV) in sulfuric acid medium followed by the reaction of unreacted Ce(IV) with leuco crystal violet (LCV) to crystal violet (CV), which is measured in an acetate buffer medium ( pH 4.9) at 580 nm. These methods obey the Beer's law in the concentration range of 0.2-1.6 µg mL-1 (method A) and 0.1-1.4 µg mL-1 (method B). The developed procedures have been successfully applied to the determination of OLZ in pure and in dosage forms. The results exhibit no interference from the presence of excipients. The reliability of the methods was established by parallel determination of OLZ against the reference method.

Spectrophotometric determination of ofloxacin in pharmaceuticals and human urine

Three simple and sensitive spectrophotometric methods are described for the determination of ofloxacin (OFX) in pharmaceuticals and in spiked human urine. First and second methods are based on the measurement of absorbance of OFX in 0.1 M HCl at 293 nm (method A) and 0.1 M NaOH at 287 nm, respectively. The third method is based on the measurement of 2:1 complex formed between OFX and iron(III) in H2SO4 medium, the complex peaking at 420 nm (method C). The optimum conditions for all the three methods are optimized. Beer's law is obeyed over the ranges 0.63-12.5 using method A and method B, and 10-120 µg mL-1 using method C. The apparent molar absorptivity values are calculated to be 3.5 × 10(4), 2.76 × 10(4) and 2.51 × 10³ L mol-1cm-1 for method A, method B and method C, respectively. The Sandell sensitivity, limit of detection (LOD) and limit quantification (LOQ) values are also reported. All the methods were validated in accordance with current ICH guidelines. The developed methods were employed with high degree of precision and accuracy for the estimation of total drug content in commercial tablet formulations of DOX. The results obtained from human spiked urine are satisfactory and recovery values are in the range 95.5-106.6%.

A Type-Preserving Compiler from System F to Typed Assembly Language

L'utilisation des méthodes formelles est de plus en plus courante dans le développement logiciel, et les systèmes de types sont la méthode formelle qui a le plus de succès. L'avancement des méthodes formelles présente de nouveaux défis, ainsi que de nouvelles opportunités. L'un des défis est d'assurer qu'un compilateur préserve la sémantique des programmes, de sorte que les propriétés que l'on garantit à propos de son code source s'appliquent également au code exécutable. Cette thèse présente un compilateur qui traduit un langage fonctionnel d'ordre supérieur avec polymorphisme vers un langage assembleur typé, dont la propriété principale est que la préservation des types est vérifiée de manière automatisée, à l'aide d'annotations de types sur le code du compilateur. Notre compilateur implante les transformations de code essentielles pour un langage fonctionnel d'ordre supérieur, nommément une conversion CPS, une conversion des fermetures et une génération de code. Nous présentons les détails des représentation fortement typées des langages intermédiaires, et les contraintes qu'elles imposent sur l'implantation des transformations de code. Notre objectif est de garantir la préservation des types avec un minimum d'annotations, et sans compromettre les qualités générales de modularité et de lisibilité du code du compilateur. Cet objectif est atteint en grande partie dans le traitement des fonctionnalités de base du langage (les «types simples»), contrairement au traitement du polymorphisme qui demande encore un travail substantiel pour satisfaire la vérification de type.

Modeling of ALFA Programs Using PVS Theorem Prover

In Safety critical software failure can have a high price. Such software should be free of errors before it is put into operation. Application of formal methods in the Software Development Life Cycle helps to ensure that the software for safety critical missions are ultra reliable. PVS theorem prover, a formal method tool, can be used for the formal verification of software in ADA Language for Flight Software Application (ALFA.). This paper describes the modeling of ALFA programs for PVS theorem prover. An ALFA2PVS translator is developed which automatically converts the software in ALFA to PVS specification. By this approach the software can be verified formally with respect to underflow/overflow errors and divide by zero conditions without the actual execution of the code.

Modeling of ALFA Programs Using PVS Theorem Prover

In Safety critical software failure can have a high price. Such software should be free of errors before it is put into operation. Application of formal methods in the Software Development Life Cycle helps to ensure that the software for safety critical missions are ultra reliable. PVS theorem prover, a formal method tool, can be used for the formal verification of software in ADA Language for Flight Software Application (ALFA.). This paper describes the modeling of ALFA programs for PVS theorem prover. An ALFA2PVS translator is developed which automatically converts the software in ALFA to PVS specification. By this approach the software can be verified formally with respect to underflow/overflow errors and divide by zero conditions without the actual execution of the code

Plan exportador software de encriptación y firma digital de documentos altamente sensibles

Este plan exportador proyectado a un plazo de 3 años, servirá a ITAC IT APPLICATIONS CONSULTING S.A. para direccionar sus actividades en el mercado internacional para los años 2009, 2010, 2011. La prioridad de los 2 primeros años será el mejoramiento interno de la empresa, que será la aplicación de estrategias en diferentes campos como: capital humano, capital intelectual, capital cultural, crecimiento económico, estrategia comercial en el área internacional, construcción de capital financiero para la generación de ingresos. Para tener participación en mercados internacionales, mostrar su potencial exportador y lograr las expectativas de crecimiento de las ventas independientes a las obtenidas en el marcado local; pretende empezar en el año 2009, en el mercado Peruano con exportaciones por $36.000 USD correspondiente a 30 unidades, aumentando a $ 72000 USD con 60 unidades en el 2010 y $ 108000 USD y 90 unidades en el 2011. El Servicio a exportar fue “SecureFile” a partir del cual se definieron factores de éxito como lo son las ventajas competitivas del producto en sí mismo enumeradas a continuación: 1) Precio muy competitivo en el mercado, 2) Automatización del proceso de intercambio de información, 3) Software basado en estándares, 4) Se ejecuta en cualquier sistema operativo. A su vez se realizaron consultorías donde se diagnosticó todas las áreas de la empresa arrojando algunos resultados: La estructura organizacional esta bien definida, pero por su crecimiento y necesidad de incluir nuevo personal, no hay claridad en las funciones dentro del organigrama y depende totalmente de la dirección general. Por esto la gerencia debe estructurar mejor los departamentos comerciales creando nuevos cargos de acuerdo al proceso de internacionalización. Las políticas de personal se trabajan de manera informal con criterios validos para promover trabajadores (mérito, antigüedad, etc.), se realizan actualizaciones Tecnológicas mensuales, reconocimiento y participación en la empresa a sus funcionarios, excelentes relaciones personales que permiten hacer evaluaciones de desempeño acorde a las metas, gran variedad de motivación y responsabilidad social encaminada a los niños de bajos recursos. Aunque se debe crear un área de gestión humana y definir la frecuencia de las capacitaciones. Los ingresos son provenientes de la prestación de servicios de IT con incrementando de 256% durante los tres años anteriores para obtener $ 2`032.784.683 millones de pesos en el 2007. El nivel de endeudamiento también ha ido en aumento, por la necesidad de capacidad instalada, contrataciones de personal, el cumplimiento de requisitos del mercado y la necesidad generar buena imagen crediticia con entidades financieras. Cuenta con un musculo financiero para respaldar sus obligaciones inmediatas con $4,42 por $1 comprometido en el 2007 a pesar de ser el año con mayor nivel de endeudamiento arrojando pasivos corrientes por $127.715.281,37. Los cuatro socios cuentan con un comportamiento de 164,67% (2006) y 132,97% (2007) de rendimiento de sobre la inversión antes de impuestos. Para este año más del 95% de su información financiera y contable se maneja de manera sistematizada. El área Financiera de la empresa no es la más débil, pero no existe un departamento financiero con un solo responsable a la cabeza, por esto deben destinar un área separada de la administrativa con un asesor financiero que tenga disponibilidad de 100%. En el caso particular del proyecto de exportación los costos de producción se centran en SecureFile versión 3.0 que no representa costos marginales, ya que la replica de este software puede hacerse cuantas veces sea requerido sin afectar en ninguna proporción los costos. La empresa no utiliza un método formal para calcular sus costos de operación y desarrollo de programas. Pero ha desarrollado un sistema de evaluación de costos en tablas de Excel que de manera organizada logran un costeo acorde a sus necesidades específicas. Para la selección de los países: objetivo, alterno y contingente; se realizó una matriz de Selección de 6 países basados en la exigencia gubernamental en términos de seguridad de la información vía internet, y la percepción de los empresarios, competencia y otros factores económicos; arrojando como resultado a Perú, Costa Rica y México.

A mission control system for an autonomous underwater vehicle

The presented work focuses on the theoretical and practical aspects concerning the design and development of a formal method to build a mission control system for autonomous underwater vehicles bringing systematic design principles for the formal description of missions using Petri nets. The proposed methodology compounds Petri net building blocks within it to de_ne a mission plan for which it is proved that formal properties, such as reachability and reusability, hold as long as these same properties are also guaranteed by each Petri net building block. To simplify the de_nition of these Petri net blocks as well as their composition, a high level language called Mission Control Language has been developed. Moreover, a methodology to ensure coordination constraints for teams of multiple robots as well as the de_nition of an interface between the proposed system and an on-board planner able to plan/replan sequences of prede_ned mission plans is included as well. Results of experiments with several real underwater vehicles and simulations involving an autonomous surface craft and an autonomous underwater vehicles are presented to show the system's capabilities.

Uma arquitetura para sistemas supervisórios industriais e sua aplicação em processos de elevação artificial de petróleo

The using of supervision systems has become more and more essential in accessing, managing and obtaining data of industrial processes, because of constant and frequent developments in industrial automation. These supervisory systems (SCADA) have been widely used in many industrial environments to store process data and to control the processes in accordance with some adopted strategy. The SCADA s control hardware is the set of equipments that execute this work. The SCADA s supervision software accesses process data through the control hardware and shows them to the users. Currently, many industrial systems adopt supervision softwares developed by the same manufacturer of the control hardware. Usually, these softwares cannot be used with other equipments made by distinct manufacturers. This work proposes an approach for developing supervisory systems able to access process information through different control hardwares. An architecture for supervisory systems is first defined, in order to guarantee efficiency in communication and data exchange. Then, the architecture is applied in a supervisory system to monitor oil wells that use distinct control hardwares. The implementation was modeled and verified by using the formal method of the Petri networks. Finally, experimental results are presented to demonstrate the applicability of the proposed solution

BTS:uma ferramenta de suporte ao desenvolvimento sistemático de sistemas confiáveis baseados em componentes

The component-based development of systems revolutionized the software development process, facilitating the maintenance, providing more confiability and reuse. Nevertheless, even with all the advantages of the development of components, their composition is an important concern. The verification through informal tests is not enough to achieve a safe composition, because they are not based on formal semantic models with which we are able to describe precisally a system s behaviour. In this context, formal methods provide ways to accurately specify systems through mathematical notations providing, among other benefits, more safety. The formal method CSP enables the specification of concurrent systems and verification of properties intrinsic to them, as well as the refinement among different models. Some approaches apply constraints using CSP, to check the behavior of composition between components, assisting in the verification of those components in advance. Hence, aiming to assist this process, considering that the software market increasingly requires more automation, reducing work and providing agility in business, this work presents a tool that automatizes the verification of composition among components, in which all complexity of formal language is kept hidden from users. Thus, through a simple interface, the tool BST (BRIC-Tool-Suport) helps to create and compose components, predicting, in advance, undesirable behaviors in the system, such as deadlocks

Indeterminaçáo e fenomenôs fronteiriços: Consideraçóes se gundo o ponto de vista do pragmatismo peirceano

Pragmatism, as a formal method, has provided a fabulous arena for discussions about the way concepts may be constructed, irrespective of any anthropomorphic or linguistic position. We will see that the pragmatic maxim possesses an interesting thesis regarding the indetermination of the meaning. Such idea helps to understand the transit between the indefinite and the defined, indeterminate and determined, as well as some found intermediate borders in the processes of relative determination.

Mediação do processo ensino-aprendizagem com o jogo de empresas mercado virtual: uma pesquisa de opinião

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Comparação da infiltração marginal de restaurações adesivas empregando instrumento rotativo ou um sistema químico-mecânico na remoção do tecido cariado

Pós-graduação em Odontologia Restauradora - ICT

Age model for the time between 3.45 and 2.45 Ma of ODP Site 189-1172

Calcareous nannoplankton assemblages and benthic d18O isotopes of Pliocene deep-sea sediments of ODP site 1172 (East of Tasmania) have been studied to improve our knowledge of the Southern Ocean paleoceanography. Our study site is located just north of the Subtropical Front (STF), an ideal setting to monitor migrations of the STF during our study period, between 3.45 and 2.45 Ma. The assemblage identified at ODP site 1172 has been interpreted as characteristic for the transitional zone water mass, located south of the STF, based on: (i) the low abundances (< 1%) of subtropical taxa, (ii) relatively high percentages of Coccolithus pelagicus, a subpolar type species, (iii) abundances from 2-10% of Calcidiscus leptoporus, a species that frequently inhabits the zone south of the STF and (iv) the high abundances of small Noelaerhabdaceae which at present dominates the zone south of the STF. Across our interval the calcareous nannoplankton manifests glacial-interglacial variability. We have identified cold events, characterized by high abundances of C. pelagicus which coincide with glacial periods, except during G7. After 3.1 Ma cold events are more frequent, in concordance with global cooling trends. Around 2.75 Ma, the interglacial stage G7 is characterized by anomalous low temperatures which most likely are linked to definite closure of the Central American Seaway (CAS), an event that is believed to have had global consequences. A gradual increase of very small Reticulofenestra across our section marks a significant trend in the small Noelaerhabdaceae species group and has been linked to a general enhanced mixing of the water column in agreement with previous studies. It is suggested that a rapid decline of small Gephyrocapsa after isotopic stage G7 might be related to the cooling observed in our study site after the closure of the CAS.