943 resultados para Asp, Peter


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Recensão de: Peter Goldie e Elisabeth Schellekens, Who’s Afraid of Conceptual Art?, Londres e Nova Iorque: Routledge, 2010

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Although the ASP model has been around for over a decade, it has not achieved the expected high level of market uptake. This research project examines the past and present state of ASP adoption and identifies security as a primary factor influencing the uptake of the model. The early chapters of this document examine the ASP model and ASP security in particular. Specifically, the literature and technology review chapter analyses ASP literature, security technologies and best practices with respect to system security in general. Based on this investigation, a prototype to illustrate the range and types of technologies that encompass a security framework was developed and is described in detail. The latter chapters of this document evaluate the practical implementation of system security in an ASP environment. Finally, this document outlines the research outputs, including the conclusions drawn and recommendations with respect to system security in an ASP environment. The primary research output is the recommendation that by following best practices with respect to security, an ASP application can provide the same level of security one would expect from any other n-tier client-server application. In addition, a security evaluation matrix, which could be used to evaluate not only the security of ASP applications but the security of any n-tier application, was developed by the author. This thesis shows that perceptions with regard to fears of inadequate security of ASP solutions and solution data are misguided. Finally, based on the research conducted, the author recommends that ASP solutions should be developed and deployed on tried, tested and trusted infrastructure. Existing Application Programming Interfaces (APIs) should be used where possible and security best practices should be adhered to where feasible.

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We have suggested previously that both the negatively and positively charged residues of the highly conserved Glu/Asp-Arg-Tyr (E/DRY) motif play an important role in the activation process of the alpha(1b)-adreneric receptor (AR). In this study, R143 of the E/DRY sequence in the alpha(1b)-AR was mutated into several amino acids (Lys, His, Glu, Asp, Ala, Asn, and Ile). The charge-conserving mutation of R143 into lysine not only preserved the maximal agonist-induced response of the alpha(1b)-AR, but it also conferred high degree of constitutive activity to the receptor. Both basal and agonist-induced phosphorylation levels were significantly increased for the R143K mutant compared with those of the wild-type receptor. Other substitutions of R143 resulted in receptor mutants with either a small increase in constitutive activity (R143H and R143D), impairment (R143H, R143D), or complete loss of receptor-mediated response (R143E, R143A, R143N, R143I). The R413E mutant displayed a small, but significant increase in basal phosphorylation despite being severely impaired in receptor-mediated response. Interestingly, all the arginine mutants displayed increased affinity for agonist binding compared with the wild-type alpha(1b)-AR. A correlation was found between the extent of the affinity shift and the intrinsic activity of the agonists. The analysis of the receptor mutants using the allosteric ternary complex model in conjunction with the results of molecular dynamics simulations on the receptor models support the hypothesis that mutations of R143 can drive the isomerization of the alpha(1b)-AR into different states, highlighting the crucial role of this residue in the activation process of the receptor.

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Aquest treball de recerca presenta l’objectiu de demostrar la vigència del concepte d’educació i política de Paulo Freire en l’actualitat a través de Peter McLaren. És a dir, no estudiar l’obra de Freire i de McLaren per separat sinó la validesa d’aquests conceptes freireans en el pensament mclarenià d’avui en dia. Justificar com la pedagogia de Freire, a partir de McLaren, continua vigent. Es realitza a partir de la recerca de textos de l’obra freireana per mostrar que avui en dia posseeix una riquesa i actualitat sorprenents.

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Implementación de un ERP (Enterprise Resource Planning) orientado al departamento de recursos humanos, que trata de agilizar las funciones de dicho departamento. Se emplea la tecnología ASP.NET 2.02, los datos se almacenan en una base de datos realizada mediante Microsoft Access, y también se utiliza una librería específíca para la generación de ficheros en formato PDF.

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Mediante el presente documento se pretende describir el proceso de creación de una herramienta de tipo CMS (Gestor de contenidos). Concretamente, se desarrollará una herramienta que permita al usuario crear su propio sitio web sin necesidad de tener conocimientos de programación. Debido a la gran variedad de sitios web tanto en su forma como en su contenido y ante la imposibilidad de abarcar todo el espectro desde la primera versión del producto, se centrarán los esfuerzos en obtener una aplicación sencilla pero funcional y, sobretodo, escalable, para que mediante futuras actualizaciones se puedan ir incrementando sus posibilidades y capacidad.