Macroeconomía y pobreza: lecciones desde Latinoamérica

Incluye Bibliografía

Application of in vivo induced antigen technology (IVIAT) to Bacillus anthracis.

In vivo induced antigen technology (IVIAT) is an immuno-screening technique that identifies bacterial antigens expressed during infection and not during standard in vitro culturing conditions. We applied IVIAT to Bacillus anthracis and identified PagA, seven members of a N-acetylmuramoyl-L-alanine amidase autolysin family, three P60 family lipoproteins, two transporters, spore cortex lytic protein SleB, a penicillin binding protein, a putative prophage holin, respiratory nitrate reductase NarG, and three proteins of unknown function. Using quantitative real-time PCR comparing RNA isolated from in vitro cultured B. anthracis to RNA isolated from BALB/c mice infected with virulent Ames strain B. anthracis, we confirmed induced expression in vivo for a subset of B. anthracis genes identified by IVIAT, including L-alanine amidases BA3767, BA4073, and amiA (pXO2-42); the bacteriophage holin gene BA4074; and pagA (pXO1-110). The exogenous addition of two purified putative autolysins identified by IVIAT, N-acetylmuramoyl-L-alanine amidases BA0485 and BA2446, to vegetative B. anthracis cell suspensions induced a species-specific change in bacterial morphology and reduction in viable bacterial cells. Many of the proteins identified in our screen are predicted to affect peptidoglycan re-modeling, and our results support significant cell wall structural remodeling activity during B. anthracis infection. Identification of L-alanine amidases with B. anthracis specificity may suggest new potential therapeutic targets.

Memoria, política y gubernamentalidad : El caso del Memorándum

La presente ponencia tiene como objetivo problematizar el vínculo existente entre memoria y política, orientando esta reflexión al surgimiento y desarrollo del Memorándum de entendimiento entre el Gobierno de la Republica Argentina y el Gobierno de la República Islámica de Irán sobre los temas relacionados al ataque terrorista a la sede de AMIA. Surgido en el 2013, nos interrogamos, a partir de la construcción conceptual foucaultiana de archivo - definido como lo enunciable y lo visible de una época - si acaso el Memorándum no constituye un ejemplo de poner a la memoria en el eje de la agenda gubernamental. A este respecto, nos hacemos las siguientes preguntas- problemas: ¿Por qué se articula una racionalidad política desde la institucionalidad política y no desde la institucionalidad de la comunidad judía? ¿Qué postura toman las organizaciones no gubernamentales, los familiares de las víctimas, en la articulación de esta iniciativa? ¿Existe una continuidad entre el discurso reivindicatorio de los derechos humanos por parte del Gobierno nacional y la confección del Memorándum? Pretendemos llevar al ámbito académico el debate sobre las líneas generales en que consiste el Memorándum y aquellos hilos de poder que lo atraviesan

Memoria, política y gubernamentalidad : El caso del Memorándum

La presente ponencia tiene como objetivo problematizar el vínculo existente entre memoria y política, orientando esta reflexión al surgimiento y desarrollo del Memorándum de entendimiento entre el Gobierno de la Republica Argentina y el Gobierno de la República Islámica de Irán sobre los temas relacionados al ataque terrorista a la sede de AMIA. Surgido en el 2013, nos interrogamos, a partir de la construcción conceptual foucaultiana de archivo - definido como lo enunciable y lo visible de una época - si acaso el Memorándum no constituye un ejemplo de poner a la memoria en el eje de la agenda gubernamental. A este respecto, nos hacemos las siguientes preguntas- problemas: ¿Por qué se articula una racionalidad política desde la institucionalidad política y no desde la institucionalidad de la comunidad judía? ¿Qué postura toman las organizaciones no gubernamentales, los familiares de las víctimas, en la articulación de esta iniciativa? ¿Existe una continuidad entre el discurso reivindicatorio de los derechos humanos por parte del Gobierno nacional y la confección del Memorándum? Pretendemos llevar al ámbito académico el debate sobre las líneas generales en que consiste el Memorándum y aquellos hilos de poder que lo atraviesan

Memoria, política y gubernamentalidad : El caso del Memorándum

La presente ponencia tiene como objetivo problematizar el vínculo existente entre memoria y política, orientando esta reflexión al surgimiento y desarrollo del Memorándum de entendimiento entre el Gobierno de la Republica Argentina y el Gobierno de la República Islámica de Irán sobre los temas relacionados al ataque terrorista a la sede de AMIA. Surgido en el 2013, nos interrogamos, a partir de la construcción conceptual foucaultiana de archivo - definido como lo enunciable y lo visible de una época - si acaso el Memorándum no constituye un ejemplo de poner a la memoria en el eje de la agenda gubernamental. A este respecto, nos hacemos las siguientes preguntas- problemas: ¿Por qué se articula una racionalidad política desde la institucionalidad política y no desde la institucionalidad de la comunidad judía? ¿Qué postura toman las organizaciones no gubernamentales, los familiares de las víctimas, en la articulación de esta iniciativa? ¿Existe una continuidad entre el discurso reivindicatorio de los derechos humanos por parte del Gobierno nacional y la confección del Memorándum? Pretendemos llevar al ámbito académico el debate sobre las líneas generales en que consiste el Memorándum y aquellos hilos de poder que lo atraviesan

INFOBIOMED: European Network of Excellence on Biomedical Informatics to support individualised healthcare

INFOBIOMED is an European Network of Excellence (NoE) funded by the Information Society Directorate-General of the European Commission (EC). A consortium of European organizations from ten different countries is involved within the network. Four pilots, all related to linking clinical and genomic information, are being carried out. From an informatics perspective, various challenges, related to data integration and mining, are included.

p-medicine: a medical informatics platform for integrated large scale heterogeneous patient data

Secure access to patient data is becoming of increasing importance, as medical informatics grows in significance, to both assist with population health studies, and patient specific medicine in support of treatment. However, assembling the many different types of data emanating from the clinic is in itself a difficulty, and doing so across national borders compounds the problem. In this paper we present our solution: an easy to use distributed informatics platform embedding a state of the art data warehouse incorporating a secure pseudonymisation system protecting access to personal healthcare data. Using this system, a whole range of patient derived data, from genomics to imaging to clinical records, can be assembled and linked, and then connected with analytics tools that help us to understand the data. Research performed in this environment will have immediate clinical impact for personalised patient healthcare.

Structural invariance of constitutively active and inactive mutants of Acanthamoeba myosin IC bound to F-actin in the rigor and ADP-bound states

The three single-headed monomeric myosin I isozymes of Acanthamoeba castellanii (AMIs)—AMIA, AMIB, and AMIC—are among the best-studied of all myosins. We have used AMIC to study structural correlates of myosin’s actin-activated ATPase. This activity is normally controlled by phosphorylation of Ser-329, but AMIC may be switched into constitutively active or inactive states by substituting this residue with Glu or Ala, respectively. To determine whether activation status is reflected in structural differences in the mode of attachment of myosin to actin, these mutant myosins were bound to actin filaments in the absence of nucleotide (rigor state) and visualized at 24-Å resolution by using cryoelectron microscopy and image reconstruction. No such difference was observed. Consequently, we suggest that regulation may be affected not by altering the static (time-averaged) structure of AMIC but by modulating its dynamic properties, i.e., molecular breathing. The tail domain of vertebrate intestinal brush-border myosin I has been observed to swing through 31° on binding of ADP. However, it was predicted on grounds of differing kinetics that any such effects with AMIC should be small [Jontes, J. D., Ostap, E. M., Pollard, T. D. & Milligan, R. A. (1998) J. Cell Biol. 141, 155–162]. We have confirmed this hypothesis by observing actin-associated AMIC in its ADP-bound state. Finally, we compared AMIC to brush-border myosin I and AMIB, which were previously studied under similar conditions. In each case, the shape and angle of attachment to F-actin of the catalytic domain is largely conserved, but the domain structure and disposition of the tail is distinctively different for each myosin.

En honor de mi bandera : proyecto pólitico y financiero para el pago o amortización de la moneda revolucionaria y del mejoramiento económico del pueblo mexicano /

Mode of access: Internet.

Vida del vener. padre fr. Francisco Fernandez Capillas, proto-martir de la China ... /

Mode of access: Internet.

Assessing the motivation of MDs to use computer-based support at the point-of-care in the emergency department

A significant body of research investigates the acceptance of computer-based support (including devices and applications ranging from e-mail to specialized clinical systems, like PACS) among clinicians. Much of this research has focused on measuring the usability of systems using characteristics related to the clarity of interactions and ease of use. We propose that an important attribute of any clinical computer-based support tool is the intrinsic motivation of the end-user (i.e. a clinician) to use the system in practice. In this paper we present the results of a study that investigated factors motivating medical doctors (MDs) to use computer-based support. Our results demonstrate that MDs value computer-based support, find it useful and easy to use, however, uptake is hindered by perceived incompetence, and pressure and tension associated with using technology.

A expressão metafórica do sentido de existir na Literatura Cabo-verdiana contemporânea: João Varela, Corsino Fortes e José Luís Tavares São

FERNANDES, M. de Fátima. A expressão metafórica do sentido de existir na Literatura Cabo-verdiana contemporânea – João Varela, Corsino Fortes e José Luís Tavares.2013. 274 f. Tese (Doutorado) FFLCH – Faculdade de Filosofia, Letras e Ciências Humanas, Universidade de São Paulo, São Paulo, 2013. A produção literária assinada pelos autores cabo-verdianos João Vário (heterônimo de João Varela), Corsino Fortes e José Luís Tavares constitui o objeto central desta análise desenvolvida a partir do estudo teórico do conceito de Identidade, visando enquadrar teoricamente a produção literária cabo-verdiana contemporânea, identificar as principais linhas de sua orientação (conteúdos, temática, estilos, retórica), relevando a receptividade da intercomunicação cultural e literária de/entre eles, bem como apresentar uma fundamentação teórica e metodológica para a leitura de suas obras. Aliando conteúdos teóricos aos contextos de produção poética pré e pós-independência, analisamos poemas das obras Exemplos (1966-1998), de João Vário, A cabeça calva de Deus (2001), de Corsino Fortes, e Agreste matéria mundo (2004), de José Luís Tavares – para verificar o posicionamento dos sujeitos literários na (re)construção da(s) identidade(s) na Literatura Cabo-Verdiana a partir dos anos 1960 do século XX à atualidade. O tratamento do tema visa caracterizar uma expressão metafórica do sentido de existir na Literatura Cabo-verdiana contemporânea, consubstanciada essencialmente no cruzamento de orientações dos estudos literários pós-estruturalistas, pós-coloniais, Estudos Comparados e Teoria da Literatura, e ainda com base na exploração de conteúdos literários com uma forte dimensão filosófica da contemporaneidade, conforme concebida por teóricos como Stuart Hall, Zigmut Bauman, Antonny Giddens, Michel Foucault, Jacques Derrida, Edward Said, Hassan Zaoual e Benedict Anderson, Milton Santos, entre outros.

Proprioception in ankle sprain from exercises and bandages

Ankle sprains are the most common injuries in sports, usually causing damage to the lateral ligaments. Recurrence has as usual result permanent instability, and thus loss of proprioception. This fact, together with residual symptoms, is what is known as chronic ankle instability, CAI, or FAI, if it is functional. This problem tries to be solved by improving musculoskeletal stability and proprioception by the application of bandages and performing exercises. The aim of this study has been to review articles (meta-analisis, systematic reviews and revisions) published in 2009-2015 in PubMed, Medline, ENFISPO and BUCea, using keywords such as “sprain instability”, “sprain proprioception”, “chronic ankle instability”. Evidence affirms that there does exist decreased proprioception in patients who suffer from CAI. Rehabilitation exercise regimen is indicated as a treatment because it generates a subjective improvement reported by the patient, and the application of bandages works like a sprain prevention method limiting the range of motion, reducing joint instability and increasing confidence during exercise. As podiatrists we should recommend proprioception exercises to all athletes in a preventive way, and those with CAI or FAI, as a rehabilitation programme, together with the application of bandages. However, further studies should be generated focusing on ways of improving proprioception, and on the exercise patterns that provide the maximum benefit.

Hallux rigidus: Arthroplasty or arthrodesis. What technique produces better results?

Hallux rígidus (HR) affects the first metatarsophalangeal joint (MTPJ) between 35% and 60% of the population over 65 years and there are multiple ways of treatment. Depending on the radiological stage where you find the deformity determines the procedure to be performed; in the early stages cheilectomy techniques and corrective osteotomy is performed while the more advanced ratings, the surgeon chooses destructive techniques considered as arthrodesis and arthroplasty. This final of degree project aims to focus on 1 MTPJ destructive techniques to clarify which of the procedures generates better results by a number of parameters; outcomes of the American Orthopaedic Foot scale and Ankle Society Hallux metatarsophalangeal Interphalangeal-scale (AOFAS), range of motion (ROM) of the 1ºAMTF, radiological classification. As for the implant arthroplasty technique, this article offers information on material and design that generates better relating to patient characteristics such as age, inflammatory joint diseases, viability and durability of the implant results. The conclusion from this review is that the values obtained in the arthrodesis according AOFAS decrease due to loss of mobility, but both techniques have similar values of effectiveness and concludes with the decision that the technique used is determined taking into account various factors and patient characteristics. Keywords: Hallux rígidus; (Hallux Rígidus) and surgery treatment; Hallux Rígidus arthrodesis; Hallux Rígidus arthroplasty; Hallux Rígidus (arthroplasty and arthrodesis).