Pisʹma Nikolai͡a︡ Ivanovicha Ilʹminskago.

Title on p. [I]: Pisʹma Nikolai͡a︡ Ivanovicha Ilʹminskago k ober-prokuroru Svi͡a︡ti͡e︡ĭshago Sinoda Konstantinu Petrovichu Pobi͡e︡donost͡s︡evu.

Zapīskī sostoi︠a︡shchago pod ̋avgusti︠e︡ǐshim ̋pokrovitelśtvom ̋ego imperatorskago vísochestva velikago kni︠a︡zía︡ Nikolai︠a︡ Mikhailovicha Uralśkago obshchestva li︠u︡biteleǐ estestvoznanii︠a︡ = Bulletin de la Société ouralienne des amis des sciences naturelles, placée sous la très auguste protection de son altesse impériale monseigneur le Grand-Duc Nicolas Mikhailovitch.

French title varies slightly.

Istorīi︠a︡ Malorossīi, Nikolai︠a︡ Markevicha.

Mode of access: Internet.

Istoricheskīe ocherki t︠s︡arstvovanīi︠a︡ imperatora Nikolai︠a︡ I.

Mode of access: Internet.

Do-petrovskai︠a︡ Rusʹ v ei︠a︡ literature : po lekt︠s︡ii︠a︡m F. I. Buslaeva E. I. V. Nasli︠e︡dniku T︠s︡esarevichu Velikomu Kni︠a︡zi︠u︡ Nikolai︠u︡ Aleksandrovichu (1859-1860 gg.) /

Record romanized.

Genome-wide association study for sight-threatening diabetic retinopathy reveals association with genetic variation near the GRB2 gene

Aims/hypothesis Diabetic retinopathy is a serious complication of diabetes mellitus and can lead to blindness. A genetic component, in addition to traditional risk factors, has been well described although strong genetic factors have not yet been identified. Here, we aimed to identify novel genetic risk factors for sight-threatening diabetic retinopathy using a genome-wide association study. Methods Retinopathy was assessed in white Australians with type 2 diabetes mellitus. Genome-wide association analysis was conducted for comparison of cases of sight-threatening diabetic retinopathy (n = 336) with diabetic controls with no retinopathy (n = 508). Top ranking single nucleotide polymorphisms were typed in a type 2 diabetes replication cohort, a type 1 diabetes cohort and an Indian type 2 cohort. A mouse model of proliferative retinopathy was used to assess differential expression of the nearby candidate gene GRB2 by immunohistochemistry and quantitative western blot. Results The top ranked variant was rs3805931 with p = 2.66 × 10−7, but no association was found in the replication cohort. Only rs9896052 (p = 6.55 × 10−5) was associated with sight-threatening diabetic retinopathy in both the type 2 (p = 0.035) and the type 1 (p = 0.041) replication cohorts, as well as in the Indian cohort (p = 0.016). The study-wide meta-analysis reached genome-wide significance (p = 4.15 × 10−8). The GRB2 gene is located downstream of this variant and a mouse model of retinopathy showed increased GRB2 expression in the retina. Conclusions/interpretation Genetic variation near GRB2 on chromosome 17q25.1 is associated with sight-threatening diabetic retinopathy. Several genes in this region are promising candidates and in particular GRB2 is upregulated during retinal stress and neovascularisation.