923 resultados para Adam, Meldrum and Anderson Dry Goods and Carpets


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Irregularities in volume numbering.

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Mode of access: Internet.

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Publisher's advertisement: 4 p. (at front of v.1); 16 p. (at front of v.2).

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At head of title: The greatest criminal of the past century; stole millions--imprisoned but once.

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Mode of access: Internet.

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Mode of access: Internet.

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http://books.google.com/books?id=plhkPFrJ1QUC&dq=law+and+custom+of+slavery+in+British+India

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Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo-2L) has emerged as a promising anticancer agent. However, resistance to TRAIL is likely to be a major problem, and sensitization of cancer cells to TRAIL may therefore be an important anticancer strategy. In this study, we examined the effect of the epidermal growth factor receptor (EGFR)tyrosine kinase inhibitor (TKI) gefitinib and a human epidermal receptor 2 (HER2)-TKI (M578440) on the sensitivity of human colorectal cancer (CRC) cell lines to recombinant human TRAIL (rhTRAIL). A synergistic interaction between rhTRAIL and gefitinib and rhTRAIL and M578440 was observed in both rhTRAIL-sensitive and resistant CRC cells. This synergy correlated with an increase in EGFR and HER2 activation after rhTRAIL treatment. Furthermore, treatment of CRC cells with rhTRAIL resulted in activation of the Src family kinases (SFK). Importantly, we found that rhTRAIL treatment induced shedding of transforming growth factor-alpha (TGF-alpha) that was dependent on SFK activity and the protease ADAM-17. Moreover, this shedding of TGF-alpha was critical for rhTRAIL-induced activation of EGFR. In support of this, SFK inhibitors and small interfering RNAs targeting ADAM-17 and TGF-alpha also sensitized CRC cells to rhTRAIL-mediated apoptosis. Taken together, our findings indicate that both rhTRAIL-sensitive and resistant CRC cells respond to rhTRAIL treatment by activating an EGFR/HER2-mediated survival response and that these cells can be sensitized to rhTRAIL using EGFR/HER2-targeted therapies. Furthermore, this acute response to rhTRAIL is regulated by SFK-mediated and ADAM-17-mediated shedding of TGF-alpha, such that targeting SFKs or inhibiting ADAM-17, in combination with rhTRAIL, may enhance the response of CRC tumors to rhTRAIL. [Cancer Res 2008;68(20):8312-21]

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Receipt to S.D. Woodruff from R. Woodruff and Co. of St. Catharines, Dealers in Dry Goods regarding payment for cardigan jacket, Sept. 19, 1875.

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Receipt to S.D. Woodruff from R. Woodruff and Co. of St. Catharines, Dealers in Dry Goods for various items such as: buttons, gloves, toweling, ties, tape and undershirts, July 1, 1876.

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Left to right: Res. of Wm. P. Brown, Sec. 6, Ann Arbor, Mich.; J.G. Miller, Manufacturer of sash, doors, blinds, mouldings, scroll work &c. ... Ann Arbor, Mich.; Ann Arbor Steam Planing Mill , Bracket, Scroll & Fancy Sawing, cor. of North & Fifth Sts., Ann Arbor, Mich. (na8635); Marble Works & Res. of Anton Eisele, the largest marble works in Washtenaw Co. Mich.; City Market, G.F. Gwinner, cor. of Fourth & Washington Sts., Ann Arbor, Mich.; L.C. Risdon, 31 South Main St., Ann Arbor, Mich. (na8635; na6707). Publication information: Chicago, Ill. : Everts & Stewart, 1874.

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Left to right: Res. of Geo. W. Hoy, Manchester, Mich.; Res. of G.R. Palmer, Manchester, Mich.; Res. of J.D. Van Duyn, Exchange St. Mich.; Res. of W.H. Pottle, Exchange Place, Manchester, Mich., cash dealer in dry goods, small wares, gents furnishing goods &c.; Res. & brick yard of Wm S. Carr, Manchester, Mich.; C.Lehn, dealer in groceries, provisions, notions &c., Manchester, Mich.; Wm. Kirchgesser, prop'r of Manchester City Bakery & wholesale & retail dealer in crackers, fine ornamental cakes, confectionery &c., Manchester, Mich.; Store & Res., Bridgewater Station, by Henry Guthardt & Sons. Publication information: Chicago, Ill. : Everts & Stewart, 1874.

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Left to right: Woodside Res. of N.B. Cole, Ann Arbor, Mich. for sale; Res. of John K. Yocum, Sec. 30, Lyndon Tp. Mich; Corner Main & Liberty Sts., Ann Arbor, Mich.; C. Parsons, dealer in dry goods, boots & shoes, hats, caps &c., Saline Mich. Publication information: Chicago, Ill. : Everts & Stewart, 1874.