Mutation screening of patients with Alzheimer disease identifies APP locus duplication in a Swedish patient.

BACKGROUND: Missense mutations in three different genes encoding amyloid-β precursor protein, presenilin 1 and presenilin 2 are recognized to cause familial early-onset Alzheimer disease. Also duplications of the amyloid precursor protein gene have been shown to cause the disease. At the Dept. of Geriatric Medicine, Karolinska University Hospital, Sweden, patients are referred for mutation screening for the identification of nucleotide variations and for determining copy-number of the APP locus. METHODS: We combined the method of microsatellite marker genotyping with a quantitative real-time PCR analysis to detect duplications in patients with Alzheimer disease. RESULTS: In 22 DNA samples from individuals diagnosed with clinical Alzheimer disease, we identified one patient carrying a duplication on chromosome 21 which included the APP locus. Further mapping of the chromosomal region by array-comparative genome hybridization showed that the duplication spanned a maximal region of 1.09 Mb. CONCLUSIONS: This is the first report of an APP duplication in a Swedish Alzheimer patient and describes the use of quantitative real-time PCR as a tool for determining copy-number of the APP locus.

Aplicación de gestión de ficheros de configuración de Asterisk : Conexión de Asterisk con Google App corportativo

El objetivo de este trabajo es desarrollar una aplicación web que sirva de gestión de los aparatos conectados a la centralita Asterisk y generar los ficheros de configuración, tanto para los terminales como para el correcto funcionamiento de la centralita. Además, se instalará un servidor que conecte centralita y Google Apps para que los usuarios puedan usar el videochat de Gmail como softphone, permitiéndoles enviar y recibir llamadas a través de la centralita de la universidad en cualquier parte del mundo.

Desenvolupament d'una App d'accés al Campus Virtual de la UOC per a dispositius Android

És objectiu d'aquest projecte dotar la comunitat UOC d'una aplicació per a dispositius Android que proporcioni als usuaris de la comunitat UOC un eina, àgil, còmode i intuïtiva d'accés al Campus Virtual i als recursos formatius que conté.

Research- Web app for android

Application development for mobile devices has evolved substantially in recent years. Creating apps for mobile systems is becoming a standard in order to create better solutions to meet the market demand. Currently, half of the US population own Smartphones. This market comprises 150 million people, and 28% of these people consider mobiles their primary way of accessing the Web (Hales, 2013). A common feature of most websites tailored for mobile devices is that they are reduced versions of the desktop site. Several factors that must be considered when making this transition from desktop sites to mobile devices are: identifying elements from the desktop website that should be displayed on the mobile device screen; the amount of information the institution (BSU in this case) wishes to provide and designing an interface that will please the users;

Playbox App : Reproductor de música sincronitzada al núvol

Aquesta aplicació per a Android permet la reproducció de música sincronitzada al núvol utilitzant un servei d'emmagatzematge, en aquest cas Dropbox.

MROGear App para dispositivos Android

Desarollo e implementación de una aplicación híbrida para dispositivos móviles Android.

Involvement of Dab1 in APP processing and [beta]-amyloid deposition in sporadic Creutzfeldt-Jakob patients.

Alzheimer"s disease and prion pathologies (e.g., Creutzfeldt-Jakob disease) display profound neural lesions associated with aberrant protein processing and extracellular amyloid deposits. For APP processing, emerging data suggest that the adaptor protein Dab1 plays a relevant role in regulating its intracellular trafficking and secretase-mediated proteolysis. Although some data have been presented, a putative relationship between human prion diseases and Dab1/APP interactions is lacking. Therefore, we have studied the putative relation between Dab1, APP processing and Aβ deposition, targets in sCJD cases. Our biochemical results categorized two groups of sCJD cases, which also correlated with PrPsc types 1 and 2 respectively. One group, with PrPsc type 1 showed increased Dab1 phosphorylation, and lower βCTF production with an absence of Aβ deposition. The second sCJD group, which carried PrPsc type 2, showed lower levels of Dab1 phosphorylation and βCTF production, similar to control cases. Relevant Aβ deposition in the second sCJD group was measured. Thus, a direct correlation between Dab1 phosphorylation, Aβ deposition and PrPsc type in human sCJD is presented for the first time.

TuTries App

Desenvolupament d'una aplicació per a infants que fa ús de la hiperficció explorativa aplicada als dispositius mòbils.

RunnerBot App

Aplicació de seguiment d'entrenaments desenvolupada en HTML5 i LungoJS, i intregrada a Android mitjançant PhoneGap.

Infocity App

Creació d'una aplicació Android per a la divulgació d'actes online.

TraumaHawk: Improving Treatment for Crash Victims Using Photos and a Smartphone App

Photographic documentation of crashed vehicles at the scene can be used to improve triage of crash victims. A U.S. expert panel developed field triage rules to determine the likelihood of occupants sustaining serious injuries based on vehicle damage that would require transport to a trauma center (Sasser et al., 2011). The use of photographs for assessing vehicle damage and occupant compartment intrusion as it correlates to increased injury severity has been validated (Davidson et al., 2014). Providing trauma staff with crash scene photos remotely could assist them in predicting injuries. This would allow trauma care providers to assess the appropriate transport, as well as develop mental models of treatment options prior to patient arrival at the emergency department (ED). Crash-scene medical response has improved tremendously in the past 20-30 years. This is in part due to the increasing number of paramedics who now have advanced life support (ALS) training that allows independence in the field. However, while this advanced training provides a more streamlined field treatment protocol, it also means that paramedics focused on treating crash victims may not have time to communicate with trauma centers regarding crash injury mechanisms. As a result, trauma centers may not learn about severe trauma patients until just a few minutes before they arrive. The information transmitted by the TraumaHawk app allows interpretation of injury mechanisms from crash scene photos at the trauma center, providing clues about the type and severity of injury. With strategic crash scene photo documentation, trained trauma professionals can assess the severity and patterns of injury based on exterior crush and occupant intrusion. Intrusion increases the force experienced by vehicle occupants, which translates into a higher level of injury severity (Tencer et al., 2005; Assal et al., 2002; Mandell et al., 2010). First responders have the unique opportunity to assess the damaged vehicle at the crash scene, but often the mechanism of injury is limited or not even relayed to ED trauma staff. To integrate photographic and scene information, an app called TraumaHawk was created to capture images of crash vehicles and send them electronically to the trauma center. If efficiently implemented, it provides the potential advantage of increasing lead-time for preparation at the trauma center through the crash scene photos. Ideally, the result is better treatment outcomes for crash victims. The objective of this analysis was to examine if the extra lead-time granted by the TraumaHawk app could improve trauma team activation time over the current conventional communication method.

TFC - APP TrailSSport

App Android para móviles, centraliza todas las competiciones deportivas, como carreras de running, medias maratones, maratones, Cross, duatlones, triatlones, carreras de Bicis,¿ permite a los deportistas estar informados en todo momento de las competiciones(o eventos) disponibles, mostrar información sobre ellas, incluso dar acceso a su web.

App Menu Today HTML5

Aplicació web en html5 multi plataforma sense necessitat d'instal·lació. L'aplicació mostrarà una petita xarxa de restaurants al món empresarial per tal de poder gestionar les reserves.

Estudi de la plataforma Google App Engine utilitzant Django

L'objectiu principal d'aquest treball es estudiar la plataforma Google App Engine en la seva versió en Phyton. Per a estudiar i provar la plataforma, s'ha desenvolupat una aplicació web de programari lliure que permet la publicació de blogs de viatges. Aquesta aplicació està desenvolupada sobre Django i s'integra amb altres serveis de Google com l'autenticació amb els seus comptes Google Maps o Picasa Web Albums.