A Candidate Gene Association Study Identifies DAPL1 as a Female-Specific Susceptibility Locus for Age-Related Macular Degeneration (AMD)

Age-related macular degeneration (AMD) is the leading cause of blindness among white caucasians over the age of 50 years with a prevalence rate expected to increase markedly with an anticipated increase in the life span of the world population. To further expand our knowledge of the genetic architecture of the disease, we pursued a candidate gene approach assessing 25 genes and a total of 109 variants. Of these, synonymous single nucleotide polymorphism (SNP) rs17810398 located in death-associated protein-like 1 (DAPL1) was found to be associated with AMD in a joint analysis of 3,229 cases and 2,835 controls from five studies [combined P ADJ = 1.15 × 10(-6), OR 1.332 (1.187-1.496)]. This association was characterized by a highly significant sex difference (P diff = 0.0032) in that it was clearly confined to females with genome-wide significance [P ADJ = 2.62 × 10(-8), OR 1.541 (1.324-1.796); males: P ADJ = 0.382, OR 1.084 (0.905-1.298)]. By targeted resequencing of risk and non-risk associated haplotypes in the DAPL1 locus, we identified additional potentially functional risk variants, namely a common 897-bp deletion and a SNP predicted to affect a putative binding site of an exonic splicing enhancer. We show that the risk haplotype correlates with a reduced retinal transcript level of two, less frequent, non-canonical DAPL1 isoforms. DAPL1 plays a role in epithelial differentiation and may be involved in apoptotic processes thereby suggesting a possible novel pathway in AMSaveD pathogenesis.

Proyecto Colombia Slow Seizures

Teniendo en cuenta las tendencias del mercado de productos para el tratamiento de la Epilepsia Refractaria en Colombia, es necesario implementar estrategias de marketing para lograr la adherencia del producto y el seguimiento del tratamiento.

Índice bibliográfico de la revista de educación de los números 330-332 y número extraordinario año 2003.

Incluye cuatro tipos de índices que facilitan la búsqueda de los artículos incluidos en los números 330 a 332. Estos índices agrupan los artículos por las notaciones de la Clasificación Decimal Universal (CDU) y por orden alfabético de autores, títulos y descriptores.

Korslagde armar och tomma kassakistor : Avdelning 332 vid Grycksbo Pappersbruk och storstrejken 1909

Syftet med uppsatsen är att undersöka hur en fackförening på en liten ort i Dalarna upplevt den stora arbetsmarknadskonflikt hösten 1909, känd som storstrejken. Hur dess medlemmar upplevde de påfrestningar de drabbades av och hur de klarade strejken och dess följder. Materialet består av mötesprotokoll från avdelningen samt den korrespondens som förekom mellan fackföreningen och förbundsledningen, och LO:s landssekretariat. I centrum för undersökningen står den under 1907 startade fackföreningen vid J.H. Munktells pappersbruk AB i Grycksbo, avdelning 332, tillhörande Grov- och Fabriksarbetarförbundet. Resultatet av undersökningen visar att fackföreningen kände en mycket begränsad entusiasm för storstrejken, beroende på dålig ekonomi och bristande tilltro till den egna förmågan. Vid strejkens början gick fackföreningen lojalt ut i strejk. Den fortsatta utvecklingen ledde till den inte ovanliga bilden med blockad och fridlysning av arbetsplatsen, strejkbryteri och ett med tiden ökande antal arbetare som gav upp strejken och sitt fackliga engagemang. För några få arbetare blev konsekvensen avsked. För fackföreningen blev konsekvensen ett drastiskt minskande medlemsantal.

Immunohistochemical and molecular expression of laminin-332 gamma-2 chain in canine mammary tumors

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Amplified bioproductivity during Transition IV (332 000-342 000 yr ago): evidence from the geochemical record of Lake El'gygytgyn

Abstract. To date, terrestrial archives of long-term climatic change within the Arctic have widely been restricted to ice cores from Greenland and, more recently, sediments from Lake El’gygytgyn in northeast Arctic Russia. Sediments from this lake contain a paleoclimate record of glacialinterglacial cycles during the last three million years. Lowresolution studies at this lake have suggested that changes observed during Transition IV (the transition from marine isotope stage (MIS) 10 to MIS 9) are of greater amplitude than any observed since. In this study, geochemical parameters are used to infer past climatic conditions thus providing the first high-resolution analyses of Transition IV from a terrestrial Arctic setting. These results demonstrate that a significant shift in climate was subsequently followed by a rapid increase in biogenic silica (BSi) production. Following this sharp increase, bioproductivity remained high, but variable, for over a thousand years. This study reveals differences in the timing and magnitude of change within the ratio of silica to titanium (Si/Ti) and BSi records that would not be apparent in lower resolution studies. This has significant implications for the increasingly common use of Si/Ti data as an alternative to traditional BSi measurements.

Anklag-Akte, errichtet durch die K. General-Staatsprokuratur der Pfalz : nebst Urtheil der Anklagekammer des k. Appellationsgerichtes der Pfalz in Zweibrücken vom 29. Juni 1850, in der Untersuchung gegen Martin Reichard, entlassener Notär in Speyer, und 332 Consorten, wegen bewaffneter Rebellion gegen die bewaffnete Macht, Hoch- und Staatsverraths &c.

Boberach: Das Ergebnis der Ermittlungen gegen 401 Teilnehmer am pfälzischen Aufstand, von denen 28 außer Verfolgung gesetzt wurden, enthält eine mit Zitaten belegte Darstellung der Ereignisse in den einzelnen Landesteilen; unter den Angeklagten sind Heinrich Didier, Karl Wilhelm Schmidt, Nikolaus Schmitt, Dr. Philipp Hepp, Peter Fries, August Culmann, Friedrich Schüler, Martini [sic!] (MdNV), Hans Alfred Erbe (MdNV), Schlöffel, Ferd. Fenner v. Fenneberg, Franz Zitz, Paquillier [sic!], Ludwig Blenker, Gottfried Kinkel, Johann [sic!] Kudlich, Franz Grün, Gustav Struve, Karl d'Ester, Friedrich Anneke [sic!], Friedrich v. Beust, Reinhard Schimmelpfennig, Franz Sznayda [sic!], August Willich, Ludwig Mieroslawsky, Victor Schily

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 796 - Rechtfertigung wegen erhobener Vorwürfe

u.a. Verkauf von Immobilienbesitz beim Bankhaus Muhl; Familienstreitigkeiten;