Long-term propensity score-matched comparison of percutaneous closure of patent foramen ovale with medical treatment after paradoxical embolism

Patients with ischemic stroke or transient ischemic attack presumably related to patent foramen ovale (PFO) are at risk for recurrent cerebrovascular events. Differences in long-term clinical outcome were investigated among patients with percutaneous PFO closure and those who received medical treatment.

Scleral buckling versus primary vitrectomy in rhegmatogenous retinal detachment study (SPR Study): recruitment list evaluation. Study report no. 2

BACKGROUND: Accompanying the patient recruitment within the "Scleral buckling versus primary vitrectomy in rhegmatogenous retinal detachment multicentre trial (SPR)", all patients with primary rhegmatogenous retinal detachment (RRD) had to be documented in a detailed recruitment list. The main goal of this analysis was to estimate the prevalence of "medium-severe" RRD (SPR Study eligible) as defined by the SPR Study inclusion criteria. In addition, the detailed anatomical situation of medium-severe RRD is investigated. METHODS: SPR Study recruitment was evaluated via a standardised questionnaire, which contained a coloured fundus drawing and information regarding possible reasons for exclusion from the SPR Study in each case. A team of three experienced vitreoretinal surgeons evaluated all fundus drawings from a 1-year period. The review led to a decision on SPR Study eligibility on the pure basis of anatomical assessment. The main outcome measures were assessment of feasible inclusion into the SPR Study by the evaluation team based on the fundus drawing and anatomical details. RESULTS: A total of 1,115 patients with RRD from 13 European centres were prospectively enrolled in the year 2000. The quality of the drawings sufficed for assessment in 1,107 cases (99.3%). Three hundred and twelve fundus drawings (28.2%) met the anatomic inclusion criteria of the SPR Study. RRD of medium severity is characterised by an average number of 2.6 (SD 2.4) retinal breaks, 5.8 (SD 2.8) clock hours of detached retina, unclear hole situation in 15.1% of cases (n=47), attached macula in 42.9% (n=134), bullous detachment in 15.1% (n=47) and vitreous haemorrhage/opacity in 7.7% (n=24). CONCLUSIONS: In the recruitment lists of the SPR Study of the year 2000, RRD of medium severity was present in nearly one third of the patients with primary RRD. These findings emphasise the clinical relevance of the SPR Study.

Developing drugs for use before, during and soon after percutaneous coronary intervention.

INTRODUCTION Percutaneous coronary intervention (PCI) is a milestone for treating coronary artery disease (CAD). Antithrombotic therapy is essential to prevent ischemic complications, including the microvascular no-reflow, while minimizing bleeding events. Areas covered: This overview discusses available and developing drugs for PCI including anticoagulants, antiplatelets and treatment of no-reflow. Expert opinion: For years unfractionated heparin (UFH) has been the unique anticoagulant to be used before and during PCI. Enoxaparin showed similar efficacy and safety, yet, based on recent trials, bivalirudin has been shown to have some benefits, particularly for patients with ST-segment elevation myocardial infarction (STEMI). The evidence concerning new anticoagulants is still preliminary, except for new oral anticoagulants, particularly rivaroxaban that showed intriguing findings and is currently under investigation. Dual antiplatelet therapy (DAPT) is the standard of care after PCI, but new developments have recently emerged. Indeed, ticagrelor and prasugrel are currently recommended over clopidogrel due to their significant reduction of ischemic events in acute coronary syndrome (ACS) whereas clopidogrel remains the choice in stable CAD. Among new agents, vorapaxar and cangrelor showed positive but limited evidence and might be considered at least in selected patients. Conversely, evidence on effective treatments for no-reflow remains limited and would require future dedicated research.

Francisco Rodríguez Adrados. Historia de la lengua griega, Madrid, Gredos 1999, 315 pp.

Fil: González de Tobia, Ana María. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

Francisco Rodríguez Adrados. Historia de la lengua griega, Madrid, Gredos 1999, 315 pp.

Fil: González de Tobia, Ana María. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

Quartus scripti Oxoniensis super sententias / [editum a fratre Joa[n]ne Duns ordinis fratrum minorum ... per ... Mauritium de Portu hiberni cum eiusdem ordinis fratrum minorum ... maxima xum diligentia emendatum].

Marca tip. xil. en colofón en 4E6r

Quartus scripti Oxoniensis super sententias / [editum a fratre Joa[n]ne Duns ordinis fratrum minorum ... per ... Mauritium de Portu hiberni cum eiusdem ordinis fratrum minorum ... maxima xum diligentia emendatum].

Marca tip. xil. en colofón en 4E6r

Dos nuevas aportaciones sobre los aspectos económicos de la Guerra Civil Española

Reseñas de: SANTACREU SOLER, José Miguel: La crisis monetaria española de 1937. Moneda y municipios en la provincia de Alicante durante la guerra civil española, Universidad de Alicante, Alicante, 1986, 182 págs.; GONZÁLEZ PORTILLA, Manuel y GARMENDIA, José María: La guerra civil en el País Vasco. Política y economía, Universidad del País Vasco-Siglo XXI de España Editores, Madrid, 1988, 154 págs.

Una experiencia de Arteterapia con mujeres con sobrepeso y obesidad

El presente artículo trata del proceso y desarrollo de una experiencia de aplicación de arteterapia con mujeres adultas en el contexto de un programa interdisciplinario de cambio de hábitos para el tratamiento de personas con sobrepeso y obesidad. Son además presentados brevemente, desde distintos autores, algunos antecedentes y puntos de relación entre el enfoque gestáltico y el arte-terapia, sirviendo como discusión que contextualiza la experiencia.