Effects of EDP-420 on penicillin-resistant and quinolone- and penicillin-resistant pneumococci in the rabbit meningitis model

OBJECTIVES: To test the efficacy of EDP-420, a new ketolide, in experimental pneumococcal meningitis and to determine its penetration into the CSF. METHODS: The experimental rabbit model was used in this study and EDP-420 was tested against a penicillin-resistant and a penicillin- and quinolone-resistant mutant. EDP-420 was also tested against both strains in time-killing assays over 8 h in vitro. RESULTS: In experimental meningitis, EDP-420 produced a bactericidal activity comparable to the standard regimen based on a combination of vancomycin with ceftriaxone against a penicillin-resistant Streptococcus pneumoniae and a penicillin- and quinolone-resistant S. pneumoniae isolate. The penetration of EDP-420 into inflamed meninges was 38% after an i.v. injection of 10 mg/kg. The bactericidal activity of EDP-420 was also confirmed in in vitro time-killing assays. CONCLUSIONS: EDP-420 is an efficacious alternative treatment in pneumococcal meningitis, especially when resistant strains are suspected.

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 420 - Zitatensammlung aus Platon, Heredot, Aristoteles, Sophokles, Porphyrius, Plotinus

2 Seiten

Na 1 Nachlass Max Horkheimer, 593 - Korrespondenzen mit Friedrich (Frederick) Pollock (p. VI 39, 1-420)

1 Brief von Frederick Pollock an Albert Rosenberg, 28.12.1958; 1 Telegramm von Max Horkheimer an Albert Rosenberg, 05.01.1958; 2 Briefe zwischen Leo Löwenthal und Frederick Pollock, 1958; 1 Brief von Leo Löwenthal an Paul Lazarsfeld, 21.02.1958; 1 Brief von Paolo Bosia an Frederick Pollock, 03.05.1958; 1 Brief von der Deutschen Angestellten Gewerkschaft (Hamburg) an Max Horkheimer, 27.03.1958; 1 Brief von Max Horkheimer an E. Brüche, 11.04.1958; 1 Brief von Leo Löwenthal an Paul F. Lazarsfeld, 21.02.1958; 1 Brief von E. Heinicke an Emmy Henne, 10.03.1958; 1 Brief von Emmy Henne an das Hotel "Haus Westend" (Frankfurt/M.), 28.02.1958; 1 Brief von Frederick Pollock an Helene Weigel, 17.02.1958; 1 Brief von Frederick Pollock an Peter Alther (Rechtsanwalt), 09.11.1959; 1 Brief von Theodor W. Adorno an Frederick Pollock, 31.08.1959;

Post-biblical history of the Jews : from the close of the Old Testament, about the year 420 B.C.E. till the destruction of the second temple, in the year 70 C.E. ; in two volumes

by Morris J. Raphall

Klaus Müller–Bergh y Gilberto Mendonça Teles. Vanguardia Latinoamericana: Historia, crítica y documentos. Tomo V, Sudamérica. Chile y países del Plata: Argentina, Uruguay, Paraguay. Madrid: Vervuert – Iberoamericana, 2009, 420 p.

Fil: Videla de Rivero, Gloria.

Iberian Margin 420 kyr geochemical and color variations record

Here we report 420 kyr long records of sediment geochemical and color variations from the southwestern Iberian Margin. We synchronized the Iberian Margin sediment record to Antarctic ice cores and speleothem records on millennial time scales and investigated the phase responses relative to orbital forcing of multiple proxy records available from these cores. Iberian Margin sediments contain strong precession power. Sediment "redness" (a* and 570-560 nm) and the ratio of long-chain alcohols to n-alkanes (C26OH/(C26OH + C29)) are highly coherent and in-phase with precession. Redder layers and more oxidizing conditions (low alcohol ratio) occur near precession minima (summer insolation maxima). We suggest these proxies respond rapidly to low-latitude insolation forcing by wind-driven processes (e.g., dust transport, upwelling, precipitation). Most Iberian Margin sediment parameters lag obliquity maxima by 7-8 ka, indicating a consistent linear response to insolation forcing at obliquity frequencies driven mainly by high-latitude processes. Although the lengths of the time series are short (420 ka) for detecting 100 kyr eccentricity cycles, the phase relationships support those obtained by Shackleton []. Antarctic temperature and the Iberian Margin alcohol ratios (C26OH/(C26OH + C29)) lead eccentricity maxima by 6 kyr, with lower ratios (increased oxygenation) occurring at eccentricity maxima. CO2, CH4, and Iberian SST are nearly in phase with eccentricity, and minimum ice volume (as inferred from Pacific d18Oseawater) lags eccentricity maxima by 10 kyr. The phase relationships derived in this study continue to support a potential role of the Earth's carbon cycle in contributing to the 100 kyr cycle.