A genetic analysis of cortical thickness in 372 twins

Imaging genetics is a new field of neuroscience that blends methods from computational anatomy and quantitative genetics to identify genetic influences on brain structure and function. Here we analyzed brain MRI data from 372 young adult twins to identify cortical regions in which gray matter volume is influenced by genetic differences across subjects. Thickness maps, reconstructed from surface models of the cortical gray/white and gray/CSF interfaces, were smoothed with a 25 mm FWHM kernel and automatically parcellated into 34 regions of interest per hemisphere. In structural equation models fitted to volume values at each surface vertex, we computed components of variance due to additive genetic (A), shared (C) and unique (E) environmental factors, and tested their significance. Cortical regions in the vicinity of the perisylvian language cortex, and at the frontal and temporal poles, showed significant additive genetic variance, suggesting that volume measures from these regions may provide quantitative phenotypes to narrow the search for quantitative trait loci that influence brain structure.

The role of lysine-41 in RNase A catalysis - A quantum chemical study on the active site ligand complex

Several mechanisms have been proposed to explain the action of enzymes at the atomic level. Among them, the recent proposals involving short hydrogen bonds as a step in catalysis by Gerlt and Gassman [1] and proton transfer through low barrier hydrogen bonds (LBHBs) [2, 3] have attracted attention. There are several limitations to experimentally testing such hypotheses, Recent developments in computational methods facilitate the study of active site-ligand complexes to high levels of accuracy, Our previous studies, which involved the docking of the dinucleotide substrate UpA to the active site of RNase A [4, 5], enabled us to obtain a realistic model of the ligand-bound active site of RNase A. From these studies, based on empirical potential functions, we were able to obtain the molecular dynamics averaged coordinates of RNase A, bound to the ligand UpA. A quantum mechanical study is required to investigate the catalytic process which involves the cleavage and formation of covalent bonds. In the present study, we have investigated the strengths of some of the hydrogen bonds between the active site residues of RNase A and UpA at the ab initio quantum chemical level using the molecular dynamics averaged coordinates as the starting point. The 49 atom system and other model systems were optimized at the 3-21G level and the energies of the optimized systems were obtained at the 6-31G* level. The results clearly indicate the strengthening of hydrogen bonds between neutral residues due to the presence of charged species at appropriate positions. Such a strengthening manifests itself in the form of short hydrogen bonds and a low barrier for proton transfer. In the present study, the proton transfer between the 2'-OH of ribose (from the substrate) and the imidazole group from the H12 of RNase A is influenced by K41, which plays a crucial role in strengthening the neutral hydrogen bond, reducing the barrier for proton transfer.

Predicting the cost of eradication for 41 Class 1 declared weeds in Queensland

The feasibility of state-wide eradication of 41 invasive plant taxa currently listed as ‘Class 1 declared pests’ under the Queensland Land Protection (Pest and Stock Route Management) Act 2002 was assessed using the predictive model ‘WeedSearch’. Results indicated that all but one species (Alternanthera philoxeroides) could be eradicated, provided sufficient funding and labour were available. Slightly less than one quarter (24.4%) (n = 10) of Class 1 weed taxa could be eradicated for less than $100 000 per taxon. An additional 43.9% (n = 18) could be eradicated for between $100 000 and $1M per taxon. Hence, 68.3% of Class 1 weed taxa (n = 28) could be eradicated for less than $1M per taxon. Eradication of 29.3% (n = 12) is predicted to cost more than $1M per taxon. Comparison of these WeedSearch outputs with either empirical analysis or results from a previous application of the model suggests that these costs may, in fact, be underestimates. Considering the likelihood that each weed will cost the state many millions of dollars in long-term losses (e.g. losses to primary production, environmental impacts and control costs), eradication seems a wise investment. Even where predicted costs are over $1M, eradication can still offer highly favourable benefit:cost ratios. The total (cumulative) cost of eradication of all 41 weed taxa is substantial; for all taxa, the estimated cost of eradication in the first year alone is $8 618 000. This study provides important information for policy makers, who must decide where to invest public funding.

Exterior view of expressionist painter Emil Luethy's home; Gotthardstr. 41 (Basel?) Architecture Residences Exterior

Handwritten on verso: zu obest mein Atelier (My studio on the top floor)

New reagents 41. Reduction of sulphonyl chlorides and sulphoxideswith aluminum iodide

Aluminium iodide reduces sulphonyl chlorides to disulphides and sulphoxides to sulphides under mild conditions in acetonitrile.

Exterior view of expressionist painter Emil Luethy's home; Gotthardstr. 41 (Basel?) Architecture Residences Exterior

Handwritten on verso: zu obest mein Atelier (My studio on the top floor)

Synthesis and catalytic properties of cobalt- and molybdenum-containing mesoporous MCM-41 molecular sieves

Mesoporous MCM-41 type silicas containing molybdenum and cobalt have been prepared with pore sizes in the range 30-38 Angstrom and 54-59 Angstrom. Catalytic properties of these materials have been examined with respect to the oxidation of cyclooctene and aniline.

A LOWER INITIAL ABUNDANCE OF SHORT-LIVED Ca-41 IN THE EARLY SOLAR SYSTEM AND ITS IMPLICATIONS FOR SOLAR SYSTEM FORMATION

The short-lived radionuclide Ca-41 plays an important role in constraining the immediate astrophysical environment and the formation timescale of the nascent solar system due to its extremely short half-life (0.1 Myr). Nearly 20 years ago, the initial ratio of Ca-41/Ca-40 in the solar system was determined to be (1.41 +/- 0.14) x 10(-8), primarily based on two Ca-Al-rich Inclusions (CAIs) from the CV chondrite Efremovka. With an advanced analytical technique for isotopic measurements, we reanalyzed the potassium isotopic compositions of the two Efremovka CAIs and inferred the initial ratios of Ca-41/Ca-40 to be (2.6 +/- 0.9) x 10(-9) and (1.4 +/- 0.6) x 10(-9) (2 sigma), a factor of 7-10 lower than the previously inferred value. Considering possible thermal processing that led to lower Al-26/Al-27 ratios in the two CAIs, we propose that the true solar system initial value of Ca-41/Ca-40 should have been similar to 4.2 x 10(-9). Synchronicity could have existed between Al-26 and Ca-41, indicating a uniform distribution of the two radionuclides at the time of CAI formation. The new initial Ca-41 abundance is 4-16 times lower than the calculated value for steady-state galactic nucleosynthesis. Therefore, Ca-41 could have originated as part of molecular cloud materials with a free decay time of 0.2-0.4 Myr. Alternative possibilities, such as a last-minute input from a stellar source and early solar system irradiation, could not be definitively ruled out. This underscores the need for more data from diverse CAIs to determine the true astrophysical origin of Ca-41.

Constraints on Be-10 and Ca-41 distribution in the early solar system from Al-26 and Be-10 studies of Efremovka CAIs

Three refractory coarse grained CAIs from the Efremovka CV3 chondrite, one (E65) previously shown to have formed with live Ca-41, were studied by ion microprobe for their Al-26-Mg-26 and Be-10-B-10 systematic in order to better understand the origin of Be-10. The high precision Al-Mg data and the inferred Al-26/Al-27 values attest that the precursors of the three CAIs evolved in the solar nebula over a period of few hundred thousand years before last melting-crystallization events. The initial Be-10/Be-9 ratios and delta B-10 values defined by the Be-10 isochrons for the three Efremovka CAIs are similar within errors. The CAI Be-10 abundance in published data underscores the large range for initial Be-10/Be-9 ratios. This is contrary to the relatively small range of Al-26/Al-27 variations in CAIs around the canonical ratio. Two models that could explain the origin of this large Be-10/Be-9 range are assessed from the collateral variations predicted for the initial delta B-10 values: (i) closed system decay of Be-10 from a ``canonical'' Be-10/Be-9 ratio and (ii) formation of CAIs from a mixture of solid precursors and nebula gas irradiated during up to a few hundred thousand years. The second scenario is shown to be the most consistent with the data. This shows that the major fraction of Be-10 in CAIs was produced by irradiation of refractory grains, while contributions of galactic cosmic rays trapping and early solar wind irradiation are less dominant. The case for Be-10 production by solar cosmic rays irradiation of solid refractory precursors poses a conundrum for Ca-41 because the latter is easily produced by irradiation and should be more abundant than what is observed in CAIs. Be-10 production by irradiation from solar energetic particles requires high Ca-41 abundance in early solar system, however, this is not observed in CAIs. (C) 2013 Elsevier B.V. All rights reserved.

Prudentia Iuris, 1996, n° 41 (número completo)

Contenido: El desarrollo de la comunidad internacional como introducción al estudio del Derecho Internacional Público / Alfredo M. de las Carreras – Las grandes transformaciones del Derecho Administrativo / Juan Carlos Cassagne – La convivencia humana y la ley moral, la verdad y la justicia en la ordenación de las relaciones internacionales : a 32 años de la Pacem in terris de S. S. Juan XXIII / José A. Giménez Rébora – El poder internacional en el Mercosur / Eduardo A. Clariá – Tratamiento del leasing en la Ley de Quiebras / Eduardo A. Barreira Delfino – La defensa nacional es cosa de todos / Emilio Barquet – Contrato de locación de vientres : nuevos proyectos de ley / Dora Rocío Laplacette – La formación del pensamiento nacional ruso / Florencio Hubeñak – Notas bibliográficas

Sapientia, 1956, Vol. XI, nº 41 (número completo)

Contenido: Filosofía y Teología en el tomismo / La Dirección – Gérmenes de idealismo en las “Investigaciones lógicas” de Husserl / Juan A. Casaubón – La materia inteligible / Emilio Mondelli – El estoicismo y su teoría del hombre / Benito R. Raffo Magnasco -- Bibliografía

Letras, 1999-2000, nº 40-41 (número completo)

Contenido: Nota preliminar – Poesía mariana en Gonzalo de Berceo / Lía N. Uriarte Rebaudi – El judío y el diablo como “otro” en los Milagros de Nuestra Señora de Berceo / Heanon M. Wilkins – “Intellectum tibi dabo et instruam te” / Eric Naylor – Descripción, narración, argumentación y crisis de la oralidad en el Libro del Buen Amor / Sofía M. Carrizo Rueda – El poema de Alfonso XI: ¿Un eco priscilianista, sabeliano, patripasiano? / Jorge Norberto Ferro – El vino en el refranero español; concordancias / Dolly M. Lucero Ontiveros – Una propuesta de clasificación de la Literatura Sapiencial Hispánica en el siglo XIII / Alicia E. Ramadori – Fray Juan García de Castrojeriz receptor de Aristóteles / Hugo Oscar Bizzarri – La especificidad de la prosa alfonsí; el caso del Lapidario / Mirta G. Aguayo – Alfonso el Sabio y Brunetto Latini: convergencias / Gretchem Arnstedt de Magneres – La figura autoral de Alfonso X en las Cantigas de Santa María / Santiago Aníbal Disalvo – La historia del rey Guillermo de Inglaterra: del relato del siglo XIV a la crónica quinientista / Carina Alejandra Zubillaga – El prólogo de “El Victorial”: heterogeneidad y orden a favor de una adecuada recepción / María Mercedes Rodríguez Temperley – A propósito del prólogo de la Confesión del amante / María Cristina Balestrini – Función de la “ekprhasis” en los relatos caballerescos / Lilia Elda Ferrario de Orduna – Una nueva fuente del Amadís de Gaula primitivo: la Waltbarii poesis del abad Ekkehard I. de Saint Gall / Aquilino Suárez Pallasá – Profecía mesiánica y profecía apocalíptica: la cuestión constantinopolitana en las Sergas de Esplandián y Primaleón / Javier Roberto González – Dos romances sefardíes de incógnito en una colección de romances. Aporte de nuevas versiones / Eleonora Angélica Alberti de Kleinbort – Conjeturas acerca del original manuscrito de la Comedia de Fernando Rojas / Germán Orduna – Fernando de Rojas, ¿autor? / Joseph Thomas Snow – El fondo medieval de la colección Foulché-Delbosc / Georgina Olivetto – Nómina de todos los congresistas

A avaliação, a regulação da educação superior e a criação do INSAES : notas sobre o Projeto de Lei nº 4.372, de 2012

Consultoria Legislativa - Área XV - Educação, Cultura, Desporto, Ciência e Tecnologia.