Sistemas de classificações geotécnicas de solos: estudo de caso aplicado à rodovia não pavimentada vcs 346, Viçosa, MG

Este artigo aborda uma contribuição às classificações geotécnicas tradicionais de solos Unified Soil Classification System (USC), Transportation Research Board System (TRB) e a Metodologia Miniatura, Compactado, Tropical (MCT) para um caso aplicado à rodovia municipal não pavimentada VCS 346, no Município de Viçosa, MG, considerando-se várias amostras deformadas de solos coletadas no subleito da referida via. Os principais objetivos deste estudo residem na contribuição de um banco de dados geotécnicos sobre classificações de solos tropicais, bem como na verificação de possíveis agrupamentos entre os sistemas geotécnicos tradicionais de classificação e a metodologia MCT. O programa de laboratório envolveu a realização dos seguintes ensaios: (i) granulometria conjunta; (ii) limites de Atterberg (LL e LP); (iii) massa específica dos grãos do solo; (iv) compactação Mini-MCV; e (v) perda de massa do corpo-de-prova por imersão em água. Os resultados possibilitaram verificar que, após a classificação das amostras, vários agrupamentos entre os sistemas de classificações geotécnicas tradicionais coincidiram com aqueles já apresentados na metodologia MCT e, considerando a pedogênese da região de Viçosa, MG, para o grupo NG', houve a contribuição dos grupos SC, SM e CL do Sistema USC e do grupo A-4 do Sistema TRB.

Influência do tráfego de veículos comerciais em rodovias vicinais não pavimentadas: estudo de caso aplicado à VCS 346, Viçosa, MG

Este artigo aborda a influência da variação da carga por eixo e da pressão de enchimento dos pneus sobre as deflexões superficiais recuperáveis previstas na estrutura de pavimento da estrada não pavimentada VCS 346, considerada representativa da malha vicinal do Município de Viçosa, MG. O programa de estudo considerou as seguintes análises: (i) contagem volumétrica do tráfego, inclusive de veículos comerciais do tipo 2C; (ii) deflexões recuperáveis previstas, em função dos dados disponíveis no estudo; (iii) estrutura do pavimento, com dados referentes ao material das camadas. Com as análises, observou-se que a aplicação de níveis mais críticos de carregamento interferiu significativamente na vida útil do pavimento e, dependendo da combinação da carga por eixo e da pressão de enchimento dos pneus, a vida útil da estrada pode sofrer redução da ordem de 89%. Investigaram-se ainda, neste trabalho, dois métodos para dimensionar a espessura do revestimento primário para rodovias não pavimentadas. Um desses métodos foi o empírico, qual seja, o método do DNIT para dimensionamento de pavimentos flexíveis; e o outro foi fundamentado em teoria elástica para sistemas de camadas. Para o dimensionamento de estradas não pavimentadas melhoradas com uma camada de revestimento primário (sistema de duas camadas), concluiu-se que o procedimento mais adequado foi o emprego da teoria elástica.

Les diplômés – no 346, été 1984

Pour toute demande de reproduction de contenu se trouvant dans cette publication, communiquer avec l’Association des diplômés de l’UdeM.

The H2S-releasing naproxen derivative, ATB-346, inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A comparative study on the anti-inflammatory effects of single oral doses of naproxen and its hydrogen sulfide (H2S)-releasing derivative ATB-346 in rats with carrageenan-induced synovitis

Abstract Background Non-steroidal antiinflammatory drugs (NSAIDs) are the most commonly prescribed agents for arthritic patients, although gastric effects limit their long-term use. Considering the reported gastric safety of hydrogen sulfide (H2S)-releasing NSAIDs, in addition to the anti-inflammatory effects of H2S administration to rats with synovitis, we decided to evaluate the effects of the H2S-releasing naproxen derivative ATB-346 in this animal model. Methods Male Wistar rats were anesthetized with inhalatory halothane and pre-treated with equimolar oral doses of either naproxen (0.3, 1, 3 or 10 mg/kg) or ATB-346 (0.48, 1.6, 4.8, or 16 mg/kg) 30 min before the i.art. injection of 7.5 mg of carrageenan (CGN) into the right knee joint cavity. Joint swelling and pain score were assessed after 1, 3 and 5 h, and tactile allodynia after 2 and 4 h. After the last measurement, the joint cavity lavages were performed for counting of the recruited leukocytes. The drugs (at the highest doses) were also tested for their gastric effects by evaluating macroscopical damage score and neutrophil recruitment (measured as myeloperoxidase – MPO activity) in the stomachs 5 h after administration of the drugs. In addition, the serum naproxen pharmacokinetic profiles of both compounds, administered at the highest equimolar doses, were obtained during the first 6 h after dosing. Results At the two highest tested doses, both naproxen and ATB-346 reduced edema and pain score (measured 3 and 5 h after CGN; P < 0.001). Tactile allodynia was similarly inhibited by ~45% 4 h after CGN by both naproxen (at 1, 3 and 10 mg/kg) and ATB-346 (at 1.6 and 4.8 mg/kg; P < 0.001), as well as leukocyte infiltration. Naproxen (but not ATB-346) induced significant gastric damage and, despite the increased gastric MPO activity by ~130% in the naproxen-, but not in the ATB-346-treated rats, this effect was of no statistical significance. Conclusion The presence of a H2S-releasing moiety in the ATB-346 structure does not impair the antiinflammatory activity of the parent compound in rats with CGN-induced synovitis. In addition, released H2S may account for the absence of deleterious gastric effects, thus making of ATB-346 a potentially useful therapeutic alternative to traditional naproxen for treatment of patients with arthritis.

A comparative study on the anti-inflammatory effects of single oral doses of naproxen and its hydrogen sulfide (H2S)-releasing derivative ATB-346 in rats with carrageenan-induced synovitis

BACKGROUND: Non-steroidal antiinflammatory drugs (NSAIDs) are the most commonly prescribed agents for arthritic patients, although gastric effects limit their long-term use. Considering the reported gastric safety of hydrogen sulfide (H2S)-releasing NSAIDs, in addition to the anti-inflammatory effects of H2S administration to rats with synovitis, we decided to evaluate the effects of the H2S-releasing naproxen derivative ATB-346 in this animal model. METHODS: Male Wistar rats were anesthetized with inhalatory halothane and pre-treated with equimolar oral doses of either naproxen (0.3, 1, 3 or 10 mg/kg) or ATB-346 (0.48, 1.6, 4.8, or 16 mg/kg) 30 min before the i.art. injection of 7.5 mg of carrageenan (CGN) into the right knee joint cavity. Joint swelling and pain score were assessed after 1, 3 and 5 h, and tactile allodynia after 2 and 4 h. After the last measurement, the joint cavity lavages were performed for counting of the recruited leukocytes. The drugs (at the highest doses) were also tested for their gastric effects by evaluating macroscopical damage score and neutrophil recruitment (measured as myeloperoxidase - MPO activity) in the stomachs 5 h after administration of the drugs. In addition, the serum naproxen pharmacokinetic profiles of both compounds, administered at the highest equimolar doses, were obtained during the first 6 h after dosing. RESULTS: At the two highest tested doses, both naproxen and ATB-346 reduced edema and pain score (measured 3 and 5 h after CGN; P < 0.001). Tactile allodynia was similarly inhibited by ~45% 4 h after CGN by both naproxen (at 1, 3 and 10 mg/kg) and ATB-346 (at 1.6 and 4.8 mg/kg; P < 0.001), as well as leukocyte infiltration. Naproxen (but not ATB-346) induced significant gastric damage and, despite the increased gastric MPO activity by ~130% in the naproxen-, but not in the ATB-346-treated rats, this effect was of no statistical significance. CONCLUSION: The presence of a H2S-releasing moiety in the ATB-346 structure does not impair the antiinflammatory activity of the parent compound in rats with CGN-induced synovitis. In addition, released H2S may account for the absence of deleterious gastric effects, thus making of ATB-346 a potentially useful therapeutic alternative to traditional naproxen for treatment of patients with arthritis.

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 346 - Bitte an Professor Hugo von Meltzl um Beteiligung am Komitee zur Errichtung des Schopenhauer-Denkmals

u.a.: Spenden; Oskar Meyer; Professor Noiré;

Ms.Ff.F.Stoltze 3. 346 - Brief von Friedrich Stoltze an Johan Christian Glücklich

Berichtigung des mißverstandenen vorhergehenden Briefs, Krebbelzeitungen, Frankfurter Latern

Miguel Angel Garrido Gallardo (Compilación y prólogo). La moderna crítica literaria hispánica. Antología. Madrid, MAPFRE, Colección Idioma e Iberoamérica, 1996, 346 págs.

Fil: Macciuci, Raquel. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.