996 resultados para 334-U1379B
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The crystal structure of shikimate kinase from Mycobacterium tuberculosis (MtSK) complexed with MgADP and shikimic acid (shikimate) has been determined at 2.3 Angstrom resolution, clearly revealing the amino acid residues involved in shikimate binding. In MtSK, the Glu61 strictly conserved in SK forms a hydrogen bond and salt-bridge with Arg58 and assists in positioning the guanidinium group of Arg58 for shikimate binding. The carboxyl group of shikimate interacts with Arg58, Gly81, and Arg136, and hydroxyl groups with Asp34 and Gly80. The crystal structure of MtSK-MgADP-shikimate will provide crucial information for elucidation of the mechanism of SK-catalyzed reaction and for the development of a new generation of drugs against tuberculosis. (C) 2004 Elsevier B.V. All rights reserved.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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15 Brief zwischen Heinrich Meng und Max Horkheimer sowie Briefwechsel mit The Johns Hopkins Hospital, Baltimore Maryland, 1935-1940; 4 Briefe zwischen dem The Johns Hopkins Hospital, Baltimore, Maryland und Max Horkheimer, 1940; 1 Brief von Werner Münsterberger an Max Horkheimer, 13.03.1940; 44 Briefe zwischen Karl Menninger vom The Menninger Clinic, The Menninger Sanatorium, Topeka, Kansas und Max Horkheimer, 1938-1941;
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u.a.: Ferdinand Laban;
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Neujahrsglückwünsche (Gedicht), Einladung nach Frankfurt
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1 Brief von Frederick Pollock an Walter Munding, 16.08.1950; 1 Brief von Frederick Pollock an Joseph Christ, 24.05.1950; 1 Brief von Albert Flegenheimer an Frederick Pollock, 18.05.1950; 2 Briefe von Frederick Pollock an E. Wehrle, 03.04.1950; 1 Brief von Margot von Mendelssohn an Max Horkheimer, 18.01.1950; 1 Brief von Nothern Life Insurance Co. (Seattle) an Max Horkheimer, 16.01.1950;
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Recent studies of abyssal peridotites (Johnson et al., 1990, doi:10.1029/JB095iB03p02661), mid-ocean-ridge basalts (MORBs) (McKenzie, 1985, doi:10.1016/0012-821X(85)90001-9) and their entrained melt inclusions (Sobolev and Shimizu, 1993, doi:10.1038/363151a0; Humler and Whitechurch, 1988, doi:10.1016/0012-821X(88)90055-6) have shown that fractional melting of the upwelling sub-oceanic mantle produces magmas with a much wider range of compositions than erupted MORBs. In particular, it seems that strongly depleted primary magmas are routinely produced by melting beneath ridges (Johnson et al., 1990, doi:10.1029/JB095iB03p02661). The absence of strongly depleted melts as erupted lavas prompts the question of how long such magmas survive beneath ridges, before their distinctive compositions are concealed by mixing with more enriched magmas. Here we report mineral compositions from a unique suite of oceanic cumulates recovered from DSDP Site 334 (Aumento et al., doi:10.2973/dsdp.proc.37.1977), which indicate that the rocks crystallized from basaltic liquids that were strongly depleted in Na, Ti, Zr, Y, Sr and rare-earth elements relative to any erupted MORB. It thus appears that the magmatic plumbing system beneath the Mid-Atlantic Ridge permitted strongly depleted magmas to accumulate in a magma chamber and remain sufficiently isolated to produce cumulate rocks. Even so, spatial heterogeneity in the compositions of high-calcium pyroxenes suggests that in the later stages of solidification these rocks reacted with infiltrating enriched basaltic liquids.
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Fil: Gassull, María José. Universidad Nacional de Cuyo
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Fil: Torchia Estrada, Juan Carlos.
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Fil: Bonnassiolle Cortés, Marcelo. Universidad de Santiago de Chile
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REE abundances in gabbros and peridotites from Site 334 of DSDP Leg 37 show that these rocks are cumulates produced by fractional crystallization of a primitive oceanic tholeiite magma. They may be part of a layered oceanic complex. The REE distributions in the residual liquids left after such a fractionation are similar to those of incompatible element-depleted oceanic tholeiites. The REE data indicate that the basalts which overlie the gabbro-peridotite complex, are not genetically related to plutonic rocks.
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Fil: Salguero, Paula Andrea. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.